Open Access

Th17 response in patients with cervical cancer (Review)

  • Authors:
    • Jayra Juliana Paiva Alves
    • Thales Allyrio Araújo de Medeiros Fernandes
    • Josélio Maria Galvão de Araújo
    • Ricardo Ney Oliveira Cobucci
    • Daniel Carlos Ferreira Lanza
    • Fabiana Lima Bezerra
    • Vânia Sousa Andrade
    • José Veríssimo Fernandes
  • View Affiliations

  • Published online on: September 21, 2018     https://doi.org/10.3892/ol.2018.9481
  • Pages: 6215-6227
  • Copyright: © Alves et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Persistent infection by high‑risk human papillomavirus (HR‑HPV) is the main risk factor for uterine cervical cancer (UCC). However, viral infection alone is not sufficient for the development and progression of premalignant cervical lesions for cancer. In previous years it has been suggested that the adaptive immune response triggered by the differentiation of naïve helper T cells in Th17 cells may serve an important role in disease development. It has been hypothesized that Th17 cells may be involved in the promotion of UCC, as high levels of interleukin 17 (IL17) expression have been detected in the mucosa of the uterine cervix of patients affected by the disease. However, the role of Th17 cells in the tumor development and progression remains unclear. It is believed that the immune response of the Th17 type during persistent infection of the genital tract with HR‑HPV triggers chronic inflammation with a long duration with the production of IL17 and other pro‑inflammatory cytokines, creating a favorable environment for tumor development. These cytokines are produced by immune system cells in addition to tumor cells and appear to function by modulating the host immune system, resulting in an immunosuppressive response as opposed to inducing an effective protective immune response, thus contributing to the growth and progression of the tumor. In the present review, the latest advances are presented about the function of Th17 cells and the cytokines produced by them in the development and progression of UCC.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Alves JJ, Fernandes TA, de Araújo JM, Cobucci RN, Lanza DC, Bezerra FL, Andrade VS and Fernandes JV: Th17 response in patients with cervical cancer (Review). Oncol Lett 16: 6215-6227, 2018
APA
Alves, J.J., Fernandes, T.A., de Araújo, J.M., Cobucci, R.N., Lanza, D.C., Bezerra, F.L. ... Fernandes, J.V. (2018). Th17 response in patients with cervical cancer (Review). Oncology Letters, 16, 6215-6227. https://doi.org/10.3892/ol.2018.9481
MLA
Alves, J. J., Fernandes, T. A., de Araújo, J. M., Cobucci, R. N., Lanza, D. C., Bezerra, F. L., Andrade, V. S., Fernandes, J. V."Th17 response in patients with cervical cancer (Review)". Oncology Letters 16.5 (2018): 6215-6227.
Chicago
Alves, J. J., Fernandes, T. A., de Araújo, J. M., Cobucci, R. N., Lanza, D. C., Bezerra, F. L., Andrade, V. S., Fernandes, J. V."Th17 response in patients with cervical cancer (Review)". Oncology Letters 16, no. 5 (2018): 6215-6227. https://doi.org/10.3892/ol.2018.9481