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Article

Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling

  • Authors:
    • Tatsuya Yunoki
    • Yoshiaki Tabuchi
    • Tetsushi Hirano
    • Shigeharu Miwa
    • Johji Imura
    • Atsushi Hayashi
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930‑0194, Japan, Division of Molecular Genetics Research, Life Science Research Center, University of Toyama, Toyama 930‑0194, Japan, Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930‑0194, Japan
  • Pages: 6729-6734
    |
    Published online on: September 21, 2018
       https://doi.org/10.3892/ol.2018.9484
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Abstract

Basal cell carcinoma (BCC) is the most frequent malignant tumor of the eyelid; it progresses slowly and rarely metastasizes. However, BCC of the eyelid is partially invasive and can extend to the surrounding ocular adnexa even if appropriate treatment is performed. To understand the molecular mechanism underlying its pathogenesis, global gene expression analysis of surgical tissue samples of BCC of the eyelid (n=2) and normal human epidermal keratinocytes was performed using a GeneChip® system. The histopathological examination of surgically removed eyelid tissues showed the tumor nest composed with small basaloid. In the samples from patients 1 and 2, 687 and 713 genes were identified, respectively, demonstrating ≥5.0‑fold higher expression than that noted in normal human epidermal keratinocytes. For the 640 genes with upregulated expression in both patient samples, Ingenuity® pathway analysis showed that the gene network in BCC of the eyelid included many BCC‑associated genes, such as the following: BCL2 apoptosis regulator; Patched‑1; and SRY‑box 9. In addition, unique gene networks related to cancer cell growth, tumorigenesis, and cell survival were identified. These results of integrating microarray analyses provide further insights into the molecular mechanisms involved in BCC of the eyelid and may provide a therapeutic approach for this disease.
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1 

Cook BE Jr and Bartley GB: Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted County, Minnesota. Ophthalmology. 106:746–750. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Allali J, D'Hermies F and Renard G: Basal cell carcinomas of the eyelids. Ophthalmologica. 219:57–71. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Neale RE, Davis M, Pandeya N, Whiteman DC and Green AC: Basal cell carcinoma on the trunk is associated with excessive sun exposure. J Am Acad Dermatol. 56:380–386. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Lindgren G, Lindblom B and Larkö O: Mohs' micrographic surgery for basal cell carcinomas on the eyelids and medial canthal area. II. Reconstruction and follow-up. Acta Ophthalmol Scand. 78:430–436. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Malhotra R, Huilgol SC, Huynh NT and Selva D: The Australian Mohs database, part II: Periocular basal cell carcinoma outcome at 5-year follow-up. Ophthalmology. 111:631–636. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Morris DS, Elzaridi E, Clarke L, Dickinson AJ and Lawrence CM: Periocular basal cell carcinoma: 5-year outcome following Slow Mohs surgery with formalin-fixed paraffin-embedded sections and delayed closure. Br J Ophthalmol. 93:474–476. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Margo CE and Waltz K: Basal cell carcinoma of the eyelid and periocular skin. Surv Ophthalmol. 38:169–192. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Diepgen TL and Mahler V: The epidemiology of skin cancer. Br J Dermatol. 146:1–6. 2002. View Article : Google Scholar : PubMed/NCBI

9 

de Zwaan SE and Haass NK: Genetics of basal cell carcinoma. Australas J Dermatol. 51:81–92; quiz 93–94. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Muller PA, Vousden KH and Norman JC: p53 and its mutants in tumor cell migration and invasion. J Cell Biol. 192:209–218. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Heller ER, Gor A, Wang D, Hu Q, Lucchese A, Kanduc D, Katdare M, Liu S and Sinha AA: Molecular signatures of basal cell carcinoma susceptibility and pathogenesis: A genomic approach. Int J Oncol. 42:583–596. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Tabuchi Y, Yunoki T, Hoshi N, Suzuki N and Kondo T: Genes and gene networks involved in sodium fluoride-elicited cell death accompanying endoplasmic reticulum stress in oral epithelial cells. Int J Mol Sci. 15:8959–8978. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yunoki T, Tabuchi Y, Hayashi A and Kondo T: Network analysis of genes involved in the enhancement of hyperthermia sensitivity by the knockdown of BAG3 in human oral squamous cell carcinoma cells. Int J Mol Med. 38:236–242. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Reifenberger J, Wolter M, Knobbe CB, Köhler B, Schönicke A, Scharwächter C, Kumar K, Blaschke B, Ruzicka T and Reifenberger G: Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol. 152:43–51. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Palmer CJ, Galan-Caridad JM, Weisberg SP, Lei L, Esquilin JM, Croft GF, Wainwright B, Canoll P, Owens DM and Reizis B: Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. Cancer Res. 74:5914–5924. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Lupu M, Caruntu C, Ghita MA, Voiculescu V, Voiculescu S, Rosca AE, Caruntu A, Moraru L, Popa IM, Calenic B, et al: Gene expression and proteome analysis as sources of biomarkers in basal cell carcinoma. Dis Markers. 2016:98312372016. View Article : Google Scholar : PubMed/NCBI

17 

Celebi AR, Kiratli H and Soylemezoglu F: Evaluation of the ‘Hedgehog’ signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva. Oncol Lett. 12:467–472. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Astarci HM, Gurbuz GA, Sengul D, Hucumenoglu S, Kocer U and Ustun H: Significance of androgen receptor and CD10 expression in cutaneous basal cell carcinoma and trichoepithelioma. Oncol Lett. 10:3466–3470. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Sharpe HJ, Pau G, Dijkgraaf GJ, Basset-Seguin N, Modrusan Z, Januario T, Tsui V, Durham AB, Dlugosz AA, Haverty PM, et al: Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma. Cancer Cell. 27:327–341. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Trautinger F, Kindas-Mügge I, Dekrout B, Knobler RM and Metze D: Expression of the 27-kDa heat shock protein in human epidermis and in epidermal neoplasms: An immunohistological study. Br J Dermatol. 133:194–202. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Vidal VP, Ortonne N and Schedl A: SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. J Cutan Pathol. 35:373–379. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Youssef KK, Lapouge G, Bouvrée K, Rorive S, Brohée S, Appelstein O, Larsimont JC, Sukumaran V, Van de Sande B, Pucci D, et al: Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol. 14:1282–1294. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Zbacnik AP, Rawal A, Lee B, Werling R, Knapp D and Mesa H: Cutaneous basal cell carcinosarcoma: Case report and literature review. J Cutan Pathol. 42:903–910. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Regl G, Kasper M, Schnidar H, Eichberger T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C, Frischauf AM and Aberger F: Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res. 64:7724–7731. 2004. View Article : Google Scholar : PubMed/NCBI

25 

He D, Li L, Zhu G, Liang L, Guan Z, Chang L, Chen Y, Yeh S and Chang C: ASC-J9 suppresses renal cell carcinoma progression by targeting an androgen receptor-dependent HIF2α/VEGF signaling pathway. Cancer Res. 74:4420–4430. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Kannan S, Sutphin RM, Hall MG, Golfman LS, Fang W, Nolo RM, Akers LJ, Hammitt RA, McMurray JS, Kornblau SM, et al: Notch activation inhibits AML growth and survival: A potential therapeutic approach. J Exp Med. 210:321–337. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Tanno B, Cesi V, Vitali R, Sesti F, Giuffrida ML, Mancini C, Calabretta B and Raschellà G: Silencing of endogenous IGFBP-5 by micro RNA interference affects proliferation, apoptosis and differentiation of neuroblastoma cells. Cell Death Differ. 12:213–223. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Sutton A, Friand V, Brulé-Donneger S, Chaigneau T, Ziol M, Sainte-Catherine O, Poiré A, Saffar L, Kraemer M, Vassy J, et al: Stromal cell-derived factor-1/chemokine (C-X-C motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion. Mol Cancer Res. 5:21–33. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Gaborit N, Abdul-Hai A, Mancini M, Lindzen M, Lavi S, Leitner O, Mounier L, Chentouf M, Dunoyer S, Ghosh M, et al: Examination of HER3 targeting in cancer using monoclonal antibodies. Proc Natl Acad Sci USA. 112:839–844. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Kesanakurti D, Chetty C, Dinh DH, Gujrati M and Rao JS: Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma. Oncogene. 32:327–340. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, et al: Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Res. 75:1091–1101. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Menouny M, Binoux M and Babajko S: Role of insulin-like growth factor binding protein-2 and its limited proteolysis in neuroblastoma cell proliferation: Modulation by transforming growth factor-beta and retinoic acid. Endocrinology. 138:683–690. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Saeki N, Gu J, Yoshida T and Wu X: Prostate stem cell antigen: A Jekyll and Hyde molecule? Clin Cancer Res. 16:3533–3538. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Northcott PA, Jones DT, Kool M, Robinson GW, Gilbertson RJ, Cho YJ, Pomeroy SL, Korshunov A, Lichter P, Taylor MD and Pfister SM: Medulloblastomics: The end of the beginning. Nat Rev Cancer. 12:818–834. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Sánchez-García I and Grütz G: Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2. Proc Natl Acad Sci USA. 92:5287–5291. 1995. View Article : Google Scholar : PubMed/NCBI

36 

Marshall ME, Hinz TK, Kono SA, Singleton KR, Bichon B, Ware KE, Marek L, Frederick BA, Raben D and Heasley LE: Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells. Clin Cancer Res. 17:5016–5025. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Schroeder A, Herrmann A, Cherryholmes G, Kowolik C, Buettner R, Pal S, Yu H, Müller-Newen G and Jove R: Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. Cancer Res. 74:1227–1237. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Vaught DB, Stanford JC, Young C, Hicks DJ, Wheeler F, Rinehart C, Sánchez V, Koland J, Muller WJ, Arteaga CL and Cook RS: HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation. Cancer Res. 72:2672–2682. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Veronese A, Lupini L, Consiglio J, Visone R, Ferracin M, Fornari F, Zanesi N, Alder H, D'Elia G, Gramantieri L, et al: Oncogenic role of miR-483-3p at the IGF2/483 locus. Cancer Res. 70:3140–3149. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Butt AJ, Dickson KA, McDougall F and Baxter RC: Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo. J Biol Chem. 278:29676–29685. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Chapman EJ, Kelly G and Knowles MA: Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells. Mol Cancer Res. 6:1154–1168. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Kunisada M, Yogianti F, Sakumi K, Ono R, Nakabeppu Y and Nishigori C: Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis. Am J Pathol. 179:3056–3065. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Tofighi R, Joseph B, Xia S, Xu ZQ, Hamberger B, Hökfelt T and Ceccatelli S: Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GalR2). Proc Natl Acad Sci USA. 105:2717–2722. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Lin Y, Fukuchi J, Hiipakka RA, Kokontis JM and Xiang J: Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from an androgen-dependent to an androgen-independent growth stage. Cell Res. 17:531–536. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Linnerth NM, Baldwin M, Campbell C, Brown M, McGowan H and Moorehead RA: IGF-II induces CREB phosphorylation and cell survival in human lung cancer cells. Oncogene. 24:7310–7319. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Kashyap AS, Hollier BG, Manton KJ, Satyamoorthy K, Leavesley DI and Upton Z: Insulin-like growth factor-I:vitronectin complex-induced changes in gene expression effect breast cell survival and migration. Endocrinology. 152:1388–1401. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Lin L, Jin Y and Hu K: Tissue-type plasminogen activator (tPA) promotes M1 macrophage survival through p90 ribosomal S6 kinase (RSK) and p38 mitogen-activated protein kinase (MAPK) pathway. J Biol Chem. 290:7910–7917. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Osborne JK, Larsen JE, Shields MD, Gonzales JX, Shames DS, Sato M, Kulkarni A, Wistuba II, Girard L, Minna JD and Cobb MH: NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Proc Natl Acad Sci USA. 110:6524–6529. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Sheikpranbabu S, Haribalaganesh R and Gurunathan S: Pigment epithelium-derived factor inhibits advanced glycation end-products-induced cytotoxicity in retinal pericytes. Diabetes Metab. 37:505–511. 2011.PubMed/NCBI

50 

Sun J, Pedersen M and Rönnstrand L: The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction. J Biol Chem. 284:11039–11047. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yunoki T, Tabuchi Y, Hirano T, Miwa S, Imura J and Hayashi A: Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling. Oncol Lett 16: 6729-6734, 2018.
APA
Yunoki, T., Tabuchi, Y., Hirano, T., Miwa, S., Imura, J., & Hayashi, A. (2018). Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling. Oncology Letters, 16, 6729-6734. https://doi.org/10.3892/ol.2018.9484
MLA
Yunoki, T., Tabuchi, Y., Hirano, T., Miwa, S., Imura, J., Hayashi, A."Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling". Oncology Letters 16.5 (2018): 6729-6734.
Chicago
Yunoki, T., Tabuchi, Y., Hirano, T., Miwa, S., Imura, J., Hayashi, A."Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling". Oncology Letters 16, no. 5 (2018): 6729-6734. https://doi.org/10.3892/ol.2018.9484
Copy and paste a formatted citation
x
Spandidos Publications style
Yunoki T, Tabuchi Y, Hirano T, Miwa S, Imura J and Hayashi A: Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling. Oncol Lett 16: 6729-6734, 2018.
APA
Yunoki, T., Tabuchi, Y., Hirano, T., Miwa, S., Imura, J., & Hayashi, A. (2018). Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling. Oncology Letters, 16, 6729-6734. https://doi.org/10.3892/ol.2018.9484
MLA
Yunoki, T., Tabuchi, Y., Hirano, T., Miwa, S., Imura, J., Hayashi, A."Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling". Oncology Letters 16.5 (2018): 6729-6734.
Chicago
Yunoki, T., Tabuchi, Y., Hirano, T., Miwa, S., Imura, J., Hayashi, A."Gene networks in basal cell carcinoma of the eyelid, analyzed using gene expression profiling". Oncology Letters 16, no. 5 (2018): 6729-6734. https://doi.org/10.3892/ol.2018.9484
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