Open Access

High expression of GALNT7 promotes invasion and proliferation of glioma cells

  • Authors:
    • Shi Hua
    • Hongyan Li
    • Yuguang Liu
    • Jian Zhang
    • Yanhao Cheng
    • Chao Dai
  • View Affiliations

  • Published online on: September 25, 2018     https://doi.org/10.3892/ol.2018.9498
  • Pages: 6307-6314
  • Copyright: © Hua et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Polypeptide‑N‑acetyl‑galactosaminlytransferase 7 (GALNT7), a member of the GalNAc‑transferase family, has not been previously evaluated as a prognostic factor of glioblastoma (GBM) or low‑grade glioma (LGG). Based on The Cancer Genome Atlas database and bioinformatics analyses, the expression of GALNT7 was demosntrated to be higher in GBM and LGG tissues than in normal brain tissue. The expression levels of GANLT7 were associated with age, tumor grade, survival rate, disease‑free survival time and overall survival time. Gene correlation and gene‑set enrichment analyses suggested that GALNT7 may affect the proliferative and invasive abilities of glioma cells through multiple signaling pathways, including regulation of the actin cytoskeleton, natural killer cell‑mediated cytotoxicity, the janus kinase‑signal transducer and activator of transcription (STAT) signaling pathway, cell adhesion molecules and extracellular matrix receptor interaction pathways. Furthermore, 5 target genes of GALNT7 involved in these signaling pathways were identified, including Crk, Rac family small GTPase 1 , STAT3, poliovirus receptor and Tenascin C. In summary, high expression of GALNT7 was associated with poor prognosis of glioma, and may be used as an effective biomarker of glioma.
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November-2018
Volume 16 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hua S, Li H, Liu Y, Zhang J, Cheng Y and Dai C: High expression of GALNT7 promotes invasion and proliferation of glioma cells. Oncol Lett 16: 6307-6314, 2018
APA
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., & Dai, C. (2018). High expression of GALNT7 promotes invasion and proliferation of glioma cells. Oncology Letters, 16, 6307-6314. https://doi.org/10.3892/ol.2018.9498
MLA
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., Dai, C."High expression of GALNT7 promotes invasion and proliferation of glioma cells". Oncology Letters 16.5 (2018): 6307-6314.
Chicago
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., Dai, C."High expression of GALNT7 promotes invasion and proliferation of glioma cells". Oncology Letters 16, no. 5 (2018): 6307-6314. https://doi.org/10.3892/ol.2018.9498