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Article Open Access

High expression of GALNT7 promotes invasion and proliferation of glioma cells

  • Authors:
    • Shi Hua
    • Hongyan Li
    • Yuguang Liu
    • Jian Zhang
    • Yanhao Cheng
    • Chao Dai
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, Shandong 250012, P.R. China, Central Laboratory, Linyi People's Hospital of Shandong University, Linyi, Shandong 276000, P.R. China, Minimally Invasive and Functional Department of Neurosurgery, Linyi People's Hospital of Shandong University, Linyi, Shandong 276000, P.R. China
    Copyright: © Hua et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6307-6314
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    Published online on: September 25, 2018
       https://doi.org/10.3892/ol.2018.9498
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Abstract

Polypeptide‑N‑acetyl‑galactosaminlytransferase 7 (GALNT7), a member of the GalNAc‑transferase family, has not been previously evaluated as a prognostic factor of glioblastoma (GBM) or low‑grade glioma (LGG). Based on The Cancer Genome Atlas database and bioinformatics analyses, the expression of GALNT7 was demosntrated to be higher in GBM and LGG tissues than in normal brain tissue. The expression levels of GANLT7 were associated with age, tumor grade, survival rate, disease‑free survival time and overall survival time. Gene correlation and gene‑set enrichment analyses suggested that GALNT7 may affect the proliferative and invasive abilities of glioma cells through multiple signaling pathways, including regulation of the actin cytoskeleton, natural killer cell‑mediated cytotoxicity, the janus kinase‑signal transducer and activator of transcription (STAT) signaling pathway, cell adhesion molecules and extracellular matrix receptor interaction pathways. Furthermore, 5 target genes of GALNT7 involved in these signaling pathways were identified, including Crk, Rac family small GTPase 1 , STAT3, poliovirus receptor and Tenascin C. In summary, high expression of GALNT7 was associated with poor prognosis of glioma, and may be used as an effective biomarker of glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Hua S, Li H, Liu Y, Zhang J, Cheng Y and Dai C: High expression of GALNT7 promotes invasion and proliferation of glioma cells. Oncol Lett 16: 6307-6314, 2018.
APA
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., & Dai, C. (2018). High expression of GALNT7 promotes invasion and proliferation of glioma cells. Oncology Letters, 16, 6307-6314. https://doi.org/10.3892/ol.2018.9498
MLA
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., Dai, C."High expression of GALNT7 promotes invasion and proliferation of glioma cells". Oncology Letters 16.5 (2018): 6307-6314.
Chicago
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., Dai, C."High expression of GALNT7 promotes invasion and proliferation of glioma cells". Oncology Letters 16, no. 5 (2018): 6307-6314. https://doi.org/10.3892/ol.2018.9498
Copy and paste a formatted citation
x
Spandidos Publications style
Hua S, Li H, Liu Y, Zhang J, Cheng Y and Dai C: High expression of GALNT7 promotes invasion and proliferation of glioma cells. Oncol Lett 16: 6307-6314, 2018.
APA
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., & Dai, C. (2018). High expression of GALNT7 promotes invasion and proliferation of glioma cells. Oncology Letters, 16, 6307-6314. https://doi.org/10.3892/ol.2018.9498
MLA
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., Dai, C."High expression of GALNT7 promotes invasion and proliferation of glioma cells". Oncology Letters 16.5 (2018): 6307-6314.
Chicago
Hua, S., Li, H., Liu, Y., Zhang, J., Cheng, Y., Dai, C."High expression of GALNT7 promotes invasion and proliferation of glioma cells". Oncology Letters 16, no. 5 (2018): 6307-6314. https://doi.org/10.3892/ol.2018.9498
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