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Article Open Access

Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection

  • Authors:
    • Zhihong Min
    • Xiaowen Pu
    • Zhengrong Gu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200127, P.R. China
    Copyright: © Min et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7189-7194
    |
    Published online on: September 28, 2018
       https://doi.org/10.3892/ol.2018.9520
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Abstract

This study investigated the expression of IL-10 and Ki-67 in human cervical cancer and cervical intraepithelial neoplasia (CIN) and the correlation with human papillomavirus infection. A total of 110 patients with cervical lesions undergoing surgical treatment in Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine from 2016 to 2017 were selected. Those patients included 36 cases of cervical cancer and 74 cases of CIN. At the same time, 30 cases of chronic cervicitis were selected as the control group. RT‑qPCR was used to detect the expression of IL‑10 and Ki‑67 in cervical tissue. PCR was used to detect HPV infection in cervical tissue. The expression levels of IL‑10 and Ki‑67 in the cervical cancer and CIN groups were higher than those in the control group. Moreover, the expression levels of IL‑10 and Ki‑67 in the cervical cancer and CIN II‑III groups were higher than those in the CIN I group (P<0.05). In addition, the expression levels of IL‑10 and Ki‑67 in the cervical cancer group were significantly higher than those in the CIN II‑III group. Furthermore, the expression levels of IL‑10 and Ki‑67 were positively correlated with HPV infection (r=0.783 or 0.712, P<0.05). Finally, the expression levels of IL‑10 and Ki‑67, and HPV infection in the cervical lesions studied were significantly different. Therefore, combined detection of IL‑10, Ki‑67 and HPV infection can improve the diagnosis of CIN and early cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Min Z, Pu X and Gu Z: Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection. Oncol Lett 16: 7189-7194, 2018.
APA
Min, Z., Pu, X., & Gu, Z. (2018). Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection. Oncology Letters, 16, 7189-7194. https://doi.org/10.3892/ol.2018.9520
MLA
Min, Z., Pu, X., Gu, Z."Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection". Oncology Letters 16.6 (2018): 7189-7194.
Chicago
Min, Z., Pu, X., Gu, Z."Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection". Oncology Letters 16, no. 6 (2018): 7189-7194. https://doi.org/10.3892/ol.2018.9520
Copy and paste a formatted citation
x
Spandidos Publications style
Min Z, Pu X and Gu Z: Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection. Oncol Lett 16: 7189-7194, 2018.
APA
Min, Z., Pu, X., & Gu, Z. (2018). Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection. Oncology Letters, 16, 7189-7194. https://doi.org/10.3892/ol.2018.9520
MLA
Min, Z., Pu, X., Gu, Z."Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection". Oncology Letters 16.6 (2018): 7189-7194.
Chicago
Min, Z., Pu, X., Gu, Z."Correlative analysis of the expression of IL‑10 and Ki‑67 in human cervical cancer and cervical intraepithelial neoplasias and human papillomavirus infection". Oncology Letters 16, no. 6 (2018): 7189-7194. https://doi.org/10.3892/ol.2018.9520
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