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Case Report Open Access

Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report

  • Authors:
    • Yan Xia
    • Xiaopeng Tian
    • Juntao Wang
    • Dongjuan Qiao
    • Xianhao Liu
    • Liang Xiao
    • Wenli Liang
    • Dongcheng Ban
    • Junjun Chu
    • Jiaming Yu
    • Rongfu Wang
    • Geng Tian
    • Mingjun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518035, P.R. China, Zhongshan School of Medicine, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen, Guangdong 518120, P.R. China, Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX 77030, USA
    Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6998-7007
    |
    Published online on: October 1, 2018
       https://doi.org/10.3892/ol.2018.9534
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Abstract

This article presented a case of a human leukocyte antigen (HLA)‑A2‑positive patient with advanced cancer/testis antigen New York esophageal squamous cell carcinoma-1 (NY‑ESO‑1) expressing lung adenocarcinoma (LADC) who received adoptive cell therapy of T cell receptor engineered‑T cells (TCR‑T cells) targeting the cancer‑testis antigen NY‑ESO‑1. The appropriate clinical and laboratory assessments were conducted to investigate the safety and efficacy of this therapy for this lung cancer patient. The patient had a clinical response to and was well‑tolerated with this therapy in the clinical trial. In addition, a preliminary evaluation of the safety of NY‑ESO‑1 TCR‑T cell therapy was performed in four patients with non‑small cell lung cancer (NSCLC) enrolled in a clinical trial. It was well‑tolerated and did not observe any serious adverse events post‑infusion. Fever, anemia, and a decrease in white blood cell count were common adverse events, which were likely due to the TCR‑T cell therapy. Two patients had clinical responses to NY‑ESO‑1 TCR‑T cell therapy, including the 44‑year‑old female patient with LADC, who achieved a short‑term partial response for 4 months, improved in Karnofsky performance status, and had a recovery of drug sensitivity. This suggests that TCR‑T cell therapy targeting NY‑ESO‑1 antigen may be beneficial for HLA‑A2‑positive late‑stage patients with NY‑ESO‑1‑expressing NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Xia Y, Tian X, Wang J, Qiao D, Liu X, Xiao L, Liang W, Ban D, Chu J, Yu J, Yu J, et al: Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report. Oncol Lett 16: 6998-7007, 2018.
APA
Xia, Y., Tian, X., Wang, J., Qiao, D., Liu, X., Xiao, L. ... Wang, M. (2018). Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report. Oncology Letters, 16, 6998-7007. https://doi.org/10.3892/ol.2018.9534
MLA
Xia, Y., Tian, X., Wang, J., Qiao, D., Liu, X., Xiao, L., Liang, W., Ban, D., Chu, J., Yu, J., Wang, R., Tian, G., Wang, M."Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report". Oncology Letters 16.6 (2018): 6998-7007.
Chicago
Xia, Y., Tian, X., Wang, J., Qiao, D., Liu, X., Xiao, L., Liang, W., Ban, D., Chu, J., Yu, J., Wang, R., Tian, G., Wang, M."Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report". Oncology Letters 16, no. 6 (2018): 6998-7007. https://doi.org/10.3892/ol.2018.9534
Copy and paste a formatted citation
x
Spandidos Publications style
Xia Y, Tian X, Wang J, Qiao D, Liu X, Xiao L, Liang W, Ban D, Chu J, Yu J, Yu J, et al: Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report. Oncol Lett 16: 6998-7007, 2018.
APA
Xia, Y., Tian, X., Wang, J., Qiao, D., Liu, X., Xiao, L. ... Wang, M. (2018). Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report. Oncology Letters, 16, 6998-7007. https://doi.org/10.3892/ol.2018.9534
MLA
Xia, Y., Tian, X., Wang, J., Qiao, D., Liu, X., Xiao, L., Liang, W., Ban, D., Chu, J., Yu, J., Wang, R., Tian, G., Wang, M."Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report". Oncology Letters 16.6 (2018): 6998-7007.
Chicago
Xia, Y., Tian, X., Wang, J., Qiao, D., Liu, X., Xiao, L., Liang, W., Ban, D., Chu, J., Yu, J., Wang, R., Tian, G., Wang, M."Treatment of metastatic non‑small cell lung cancer with NY‑ESO‑1 specific TCR engineered‑T cells in a phase I clinical trial: A case report". Oncology Letters 16, no. 6 (2018): 6998-7007. https://doi.org/10.3892/ol.2018.9534
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