Clinical significance of reduced GPRC5A expression in surgically resected non‑small cell lung cancer

  • Authors:
    • Er Jin
    • Wenzhe Wang
    • Mengdie Fang
    • Wei Wang
    • Ruifei Xie
    • Hong Zhou
    • Jian Ye
    • Rujun Xu
    • Shenglin Ma
  • View Affiliations

  • Published online on: October 2, 2018     https://doi.org/10.3892/ol.2018.9537
  • Pages: 502-507
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Abstract

G protein‑coupled receptor, family C, group 5 member A (GPRC5A) is a retinoid‑inducible protein, which has been characterized as a tumor‑suppressor gene in lung cancer. The present study further examined GPRC5A expression in non‑small cell lung cancer (NSCLC) for any association with the clinical features and treatment outcomes of patients with NSCLC. A total of 30 paired NSCLC tumor and adjacent normal tissues were analyzed for the detection of GPRC5A mRNA and protein using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blot analysis, respectively. Immunohistochemistry was performed to determine the GPRC5A expression levels in 110 NSCLC and 60 para‑tumor tissues. The results confirmed significantly lower expression levels of GPRC5A in NSCLC tumors compared with the corresponding noncancerous tissues (P<0.001). Lost GPRC5A expression was significantly associated with the tumor histological type (P=0.008), poor tumor differentiation (P<0.001) and tumor‑node‑metastasis (TNM) stage (P<0.001). Kaplan‑Meier curve analysis revealed that patients with NSCLC with low GPRC5A expression tumors had a worse prognosis compared with those with high GPRC5A expression tumors (P=0.010). The results of multivariate Cox analysis further suggested that low GPRC5A expression was an independent prognostic factor for patients with NSCLC (P<0.001). The results of this study suggest GPRC5A expression has clinical potential as a prognostic biomarker for patients with NSCLC.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jin E, Wang W, Fang M, Wang W, Xie R, Zhou H, Ye J, Xu R and Ma S: Clinical significance of reduced GPRC5A expression in surgically resected non‑small cell lung cancer. Oncol Lett 17: 502-507, 2019
APA
Jin, E., Wang, W., Fang, M., Wang, W., Xie, R., Zhou, H. ... Ma, S. (2019). Clinical significance of reduced GPRC5A expression in surgically resected non‑small cell lung cancer. Oncology Letters, 17, 502-507. https://doi.org/10.3892/ol.2018.9537
MLA
Jin, E., Wang, W., Fang, M., Wang, W., Xie, R., Zhou, H., Ye, J., Xu, R., Ma, S."Clinical significance of reduced GPRC5A expression in surgically resected non‑small cell lung cancer". Oncology Letters 17.1 (2019): 502-507.
Chicago
Jin, E., Wang, W., Fang, M., Wang, W., Xie, R., Zhou, H., Ye, J., Xu, R., Ma, S."Clinical significance of reduced GPRC5A expression in surgically resected non‑small cell lung cancer". Oncology Letters 17, no. 1 (2019): 502-507. https://doi.org/10.3892/ol.2018.9537