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Article

Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus

  • Authors:
    • Dasom Son
    • Hyun-Kyung Kong
    • Yesol Kim
    • Min-Ji Song
    • Hyong Pyo Kim
    • Han Woong Lee
    • Jong Hoon Park
  • View Affiliations

    Affiliations: Department of Biological Science, Sookmyung Women's University, Seoul 04310, Republic of Korea, Department of Environmental Medical Biology, Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea, Department of Biochemistry, Yonsei University, Seoul 03722, Republic of Korea
  • Published online on: October 4, 2018     https://doi.org/10.3892/ol.2018.9548
  • Pages: 379-387
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Abstract

Lymphocyte antigen 6 family member K (LY6K) is upregulated in a number of types of cancer and promotes tumor cell proliferation and metastasis. In addition, LY6K is involved in tamoxifen resistance in breast cancer. However, the in vivo molecular mechanism of LY6K has not yet been investigated. In the present study, transgenic mice overexpressing human LY6K (hLY6K) were generated using the pMAMneo vector, and the effect of LY6K upregulation in vivo was investigated. A total of 4 transgenic mice were generated, and the gene copy number was examined using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). RT‑qPCR demonstrated that mRNA of hLY6K was overexpressed in the thymus and spleen of the transgenic mice compared with wild‑type mice. Flow cytometric analysis demonstrated that the proportions of B and T cells in the spleen were similar in wild‑type and transgenic mice; however, the proportion of thymic mature T cells decreased in the transgenic mice, while there was an increase in the proportion of naïve T cells. These findings suggest that the overexpression of LY6K suppresses T cell development, and that LY6K is a potential therapeutic target for cancer.
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1 

Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S and Swamynathan SK: Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Hum Genomics. 10:102016. View Article : Google Scholar : PubMed/NCBI

2 

Blasi F and Sidenius N: The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling. FEBS Lett. 584:1923–1930. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Smith HW and Marshall CJ: Regulation of cell signalling by uPAR. Nat Rev Mol Cell Biol. 11:23–36. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Kim SH, Turnbull J and Guimond S: Extracellular matrix and cell signalling: The dynamic cooperation of integrin, proteoglycan and growth factor receptor. J Endocrinol. 209:139–151. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Parnaud G, Hammar E, Ribaux P, Donath MY, Berney T and Halban PA: Signaling pathways implicated in the stimulation of beta-cell proliferation by extracellular matrix. Mol Endocrinol. 23:1264–1271. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Blasi F and Carmeliet P: uPAR: A versatile signalling orchestrator. Nat Rev Mol Cell Biol. 3:932–943. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Huber MC, Mall R, Braselmann H, Feuchtinger A, Molatore S, Lindner K, Walch A, Gross E, Schmitt M, Falkenberg N and Aubele M: uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R. BMC Cancer. 16:6152016. View Article : Google Scholar : PubMed/NCBI

8 

Jacobsen B and Ploug M: The urokinase receptor and its structural homologue C4.4A in human cancer: Expression, prognosis and pharmacological inhibition. Curr Med Chem. 15:2559–2573. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Bené MC, Castoldi G, Knapp W, Rigolin GM, Escribano L, Lemez P, Ludwig WD, Matutes E, Orfao A, Lanza F, et al: CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: A review. Leukemia. 18:394–400. 2004. View Article : Google Scholar : PubMed/NCBI

10 

de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, Nieuwenhuis EJ, Stigter-van Walsum M, Snow GB and Brakenhoff RH: Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma. Int J Cancer. 103:768–774. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Matsuda R, Enokida H, Chiyomaru T, Kikkawa N, Sugimoto T, Kawakami K, Tatarano S, Yoshino H, Toki K, Uchida Y, et al: LY6K is a novel molecular target in bladder cancer on basis of integrate genome-wide profiling. Br J Cancer. 104:376–386. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Zhang B, Zhang Z, Zhang X, Gao X, Kernstine KH and Zhong L: Serological antibodies against LY6K as a diagnostic biomarker in esophageal squamous cell carcinoma. Biomarkers. 17:372–378. 2012. View Article : Google Scholar : PubMed/NCBI

13 

AlHossiny M, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R and Upadhyay G: Ly6E/K Signaling to TGFβ promotes breast cancer progression, immune escape, and drug resistance. Cancer Res. 76:3376–3386. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Kong HK, Park SJ, Kim YS, Kim KM, Lee HW, Kang HG, Woo YM, Park EY, Ko JY, Suzuki H, et al: Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma. Oncotarget. 7:55677–55689. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Kong HK, Yoon S and Park JH: The regulatory mechanism of the LY6K gene expression in human breast cancer cells. J Biol Chem. 287:38889–38900. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Balakrishnan K and Adams LE: The role of the lymphocyte in an immune response. Immunol Invest. 24:233–244. 1995. View Article : Google Scholar : PubMed/NCBI

17 

Roth PE and DeFranco AL: Lymphocyte development: Intrinsic checkpoints for lineage progression. Curr Biol. 5:349–352. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Nagasawa T: Microenvironmental niches in the bone marrow required for B-cell development. Nat Rev Immunol. 6:107–116. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Lai AY and Kondo M: T and B lymphocyte differentiation from hematopoietic stem cell. Semin Immunol. 20:207–212. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Zúñiga-Pflücker JC: T-cell development made simple. Nat Rev Immunol. 4:67–72. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Germain RN: T-cell development and the CD4-CD8 lineage decision. Nat Rev Immunol. 2:309–322. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Choi SH, Kong HK, Park SY and Park JH: Metastatic effect of LY-6K gene in breast cancer cells. Int J Oncol. 35:601–607. 2009.PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Lin J, Zhang Q, Zhu LQ, Yu QH and Yang Q: The copy number and integration site analysis of IGF-1 transgenic goat. Int J Mol Med. 34:900–910. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Altschul SF, Gish W, Miller W, Myers EW and Lipman DJ: Basic local alignment search tool. J Mol Biol. 215:403–410. 1990. View Article : Google Scholar : PubMed/NCBI

26 

Batista FD and Harwood NE: The who, how and where of antigen presentation to B cells. Nat Rev Immunol. 9:15–27. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Xu D, Liu H, Komai-Koma M, Campbell C, McSharry C, Alexander J and Liew FY: CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J Immunol. 170:394–399. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Amu S, Gjertsson I, Tarkowski A and Brisslert M: B-cell CD25 expression in murine primary and secondary lymphoid tissue. Scand J Immunol. 64:482–492. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Hager-Theodorides AL, Rowbotham NJ, Outram SV, Dessens JT and Crompton T: Beta-selection: Abundance of TCRbeta-/gammadelta-CD44-CD25-(DN4) cells in the foetal thymus. Eur J Immunol. 37:487–500. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y and Upadhyay G: Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome. Oncotarget. 7:11165–11193. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Kim YS, Park SJ, Lee YS, Kong HK and Park JH: miRNAs involved in LY6K and estrogen receptor α contribute to tamoxifen-susceptibility in breast cancer. Oncotarget. 7:42261–42273. 2016.PubMed/NCBI

32 

Bryant CD, Zhang NN, Sokoloff G, Fanselow MS, Ennes HS, Palmer AA and McRoberts JA: Behavioral differences among C57BL/6 substrains: Implications for transgenic and knockout studies. J Neurogenet. 22:315–331. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Simon MM, Greenaway S, White JK, Fuchs H, Gailus-Durner V, Wells S, Sorg T, Wong K, Bedu E, Cartwright EJ, et al: A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol. 14:R822013. View Article : Google Scholar : PubMed/NCBI

34 

Dudley JP, Golovkina TV and Ross SR: Lessons learned from mouse mammary tumor virus in animal models. ILAR J. 57:12–23. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Ross SR: Mouse mammary tumor virus molecular biology and oncogenesis. Viruses. 2:2000–2012. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Taneja P, Frazier DP, Kendig RD, Maglic D, Sugiyama T, Kai F, Taneja NK and Inoue K: MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer. Expert Rev Mol Diagn. 9:423–440. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Fantozzi A and Christofori G: Mouse models of breast cancer metastasis. Breast Cancer Res. 8:2122006. View Article : Google Scholar : PubMed/NCBI

38 

Yang G, Park S, Cao G, Goltsov A, Ren C, Truong LD, Demayo F and Thompson TC: MMTV promoter-regulated caveolin-1 overexpression yields defective parenchymal epithelia in multiple exocrine organs of transgenic mice. Exp Mol Pathol. 89:9–19. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Bérard J, Gaboury L, Landers M, De Repentigny Y, Houle B, Kothary R and Bradley WE: Hyperplasia and tumours in lung, breast and other tissues in mice carrying a RAR beta 4-like transgene. EMBO J. 13:5570–5580. 1994. View Article : Google Scholar : PubMed/NCBI

40 

Davies BR, Platt-Higgins AM, Schmidt G and Rudland PS: Development of hyperplasias, preneoplasias, and mammary tumors in MMTV-c-erbB-2 and MMTV-TGFα transgenic rats. Am J Pathol. 155:303–314. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Haraguchi S, Good RA, Engelman RW and Day NK: Human prolactin regulates transfected MMTV LTR-directed gene expression in a human breast-carcinoma cell line through synergistic interaction with steroid hormones. Int J Cancer. 52:928–933. 1992. View Article : Google Scholar : PubMed/NCBI

42 

Kennedy R and Celis E: Multiple roles for CD4+ T cells in anti-tumor immune responses. Immunol Rev. 222:129–144. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Pluhar GE, Pennell CA and Olin MR: CD8+ T Cell-independent immune-mediated mechanisms of anti-tumor activity. Crit Rev Immunol. 35:153–172. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Huppa JB and Davis MM: T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol. 3:973–983. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Pardoll DM and Topalian SL: The role of CD4+ T cell responses in antitumor immunity. Curr Opinion Immunol. 10:588–594. 1998. View Article : Google Scholar

46 

Kast WM, Offringa R, Peters PJ, Arie CV, Rob HM, Alex JV and Cornelis JMM: Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes. Cell. 59:603–614. 1989. View Article : Google Scholar : PubMed/NCBI

47 

Haabeth OA, Tveita AA, Fauskanger M, Schjesvold F, Lorvik KB, Hofgaard PO, Omholt H, Munthe LA, Dembic Z, Corthay A and Bogen B: How Do CD4(+) T cells detect and eliminate tumor cells that either lack or express MHC Class II molecules? Front Immunol. 5:1742014. View Article : Google Scholar : PubMed/NCBI

48 

Gao FG, Khammanivong V, Liu WJ, Leggatt GR, Frazer IH and Fernando GJ: Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cell. Cancer Res. 62:6438–6441. 2002.PubMed/NCBI

49 

Zanetti M: Tapping CD4 T cells for cancer immunotherapy: The choice of personalized genomics. J Immunol. 194:2049–2056. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Wang RF: The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity. Trends Immunol. 22:269–276. 2001. View Article : Google Scholar : PubMed/NCBI

51 

Sehgal I, Foster TP and Francis J: Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis. Cancer Cell Int. 6:212006. View Article : Google Scholar : PubMed/NCBI

52 

Park SB, Kim HH, Shin HJ, Paik MH, Kim DB and Gong G: Thymic metastasis in breast cancer: A case report. Korean J Radiol. 8:360–363. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Peters HC, Liu X, Iqbal A, Cunningham LA and Tan SA: Colorectal cancer metastasis to the thymus gland: Rare presentation of colorectal cancer as anterior mediastinal mass. Case Rep Surg. 2017:65819652017.PubMed/NCBI

54 

Hayashi S, Hamanaka Y, Sueda T, Yonehara S and Matsuura Y: Thymic metastasis from prostatic carcinoma: Report of a case. Surg Today. 23:632–634. 1993. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Son D, Kong H, Kim Y, Song M, Kim HP, Lee HW and Park JH: Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus. Oncol Lett 17: 379-387, 2019.
APA
Son, D., Kong, H., Kim, Y., Song, M., Kim, H.P., Lee, H.W., & Park, J.H. (2019). Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus. Oncology Letters, 17, 379-387. https://doi.org/10.3892/ol.2018.9548
MLA
Son, D., Kong, H., Kim, Y., Song, M., Kim, H. P., Lee, H. W., Park, J. H."Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus". Oncology Letters 17.1 (2019): 379-387.
Chicago
Son, D., Kong, H., Kim, Y., Song, M., Kim, H. P., Lee, H. W., Park, J. H."Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus". Oncology Letters 17, no. 1 (2019): 379-387. https://doi.org/10.3892/ol.2018.9548
Copy and paste a formatted citation
x
Spandidos Publications style
Son D, Kong H, Kim Y, Song M, Kim HP, Lee HW and Park JH: Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus. Oncol Lett 17: 379-387, 2019.
APA
Son, D., Kong, H., Kim, Y., Song, M., Kim, H.P., Lee, H.W., & Park, J.H. (2019). Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus. Oncology Letters, 17, 379-387. https://doi.org/10.3892/ol.2018.9548
MLA
Son, D., Kong, H., Kim, Y., Song, M., Kim, H. P., Lee, H. W., Park, J. H."Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus". Oncology Letters 17.1 (2019): 379-387.
Chicago
Son, D., Kong, H., Kim, Y., Song, M., Kim, H. P., Lee, H. W., Park, J. H."Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus". Oncology Letters 17, no. 1 (2019): 379-387. https://doi.org/10.3892/ol.2018.9548
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