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Article

Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system

  • Authors:
    • İdi̇l Çeti̇n
    • Mehmet R. Topçul
  • View Affiliations / Copyright

    Affiliations: Department of Biology, Faculty of Science, Istanbul University, Istanbul 34459, Turkey
  • Pages: 683-687
    |
    Published online on: October 9, 2018
       https://doi.org/10.3892/ol.2018.9556
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Abstract

In the present study, the in vitro cytotoxic effect of a novel transforming growth factor‑β receptor inhibitor, LY2109761, was investigated in the human cervix carcinoma HeLa cell lines. For the purpose of the present study, cell index values obtained using the xCELLigence Real‑Time Cell Analysis DP instrument, and mitotic, labelling and apoptotic index analysis were used. The results of the present study indicated that LY2109761 affected the cytoskeleton of HeLa cells, decreased the mitotic and labelling index values of the HeLa cell line, and increased the apoptotic index values. Significant differences were observed between the control group which was not treated with LY2109761 and the experimental groups, which were treated with LY2109761 (P<0.01). The results of the present study suggest that LY2109761 may serve as a promising treatment option for cervix carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Çeti̇n İ and Topçul MR: Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system. Oncol Lett 17: 683-687, 2019.
APA
Çeti̇n, İ., & Topçul , M.R. (2019). Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system. Oncology Letters, 17, 683-687. https://doi.org/10.3892/ol.2018.9556
MLA
Çeti̇n, İ., Topçul , M. R."Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system". Oncology Letters 17.1 (2019): 683-687.
Chicago
Çeti̇n, İ., Topçul , M. R."Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system". Oncology Letters 17, no. 1 (2019): 683-687. https://doi.org/10.3892/ol.2018.9556
Copy and paste a formatted citation
x
Spandidos Publications style
Çeti̇n İ and Topçul MR: Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system. Oncol Lett 17: 683-687, 2019.
APA
Çeti̇n, İ., & Topçul , M.R. (2019). Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system. Oncology Letters, 17, 683-687. https://doi.org/10.3892/ol.2018.9556
MLA
Çeti̇n, İ., Topçul , M. R."Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system". Oncology Letters 17.1 (2019): 683-687.
Chicago
Çeti̇n, İ., Topçul , M. R."Evaluation of the cytotoxic effect of Ly2109761 on HeLa cells using the xCELLigence RTCA system". Oncology Letters 17, no. 1 (2019): 683-687. https://doi.org/10.3892/ol.2018.9556
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