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A clinical study on the expression of PTEN in renal cell carcinoma in children

  • Authors:
    • Hong Lu
    • Yuxia Tan
    • Liping Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Zibo Maternal and Child Health Care Hospital, Zibo, Shandong 255029, P.R. China
  • Pages: 69-72
    |
    Published online on: October 12, 2018
       https://doi.org/10.3892/ol.2018.9571
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Abstract

The expression pattern of tumor suppressor gene phosphatase and tensin homolog deleted on chromosome ten (PTEN) and phosphatase and tensin homolog deleted on chromosome ten/phosphatidylinositol3-kinase/protein kinase B (PTEN/PI3K/AKT) cell signaling pathway in renal cell carcinoma (RCC) were investigated in children. A total of 5 cases of RCC (observation group) in children and 10 cases of benign kidney tumor (control group) diagnosed by pathological examinations were included to obtain tumor samples. Expression of PTEN mRNA was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The protein expression of PTEN, PI3K and AKT was detected by western blotting; relationships between the expression level of PTEN mRNA and the clinical features of RCC were analyzed. It turned out that expression level of PTEN mRNA in the observation group was significantly lower than that in the control group. The protein expression levels of PTEN, PI3K and AKT were significantly lower in the observation group than in the control group (P<0.05). The expression level of PTEN mRNA decreased with the increased clinical stage of RCC (P<0.05), and was not related to sex, age and maximum tumor diame-ter (P>0.05). The results showed that downregulation of the tumor suppressor gene PTEN expression and the inhibition of PTEN/PI3K/AKT cell signaling pathway may be involved in the occurrence and development of RCC in children.
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1 

Graves A, Hessamodini H, Wong G and Lim WH: Metastatic renal cell carcinoma: Update on epidemiology, genetics, and therapeutic modalities. Immunotargets Ther. 2:73–90. 2013.PubMed/NCBI

2 

Szychot E, Apps J and Pritchard-Jones K: Wilms' tumor: Biology, diagnosis and treatment. Transl Pediatr. 3:12–24. 2014.PubMed/NCBI

3 

Silberstein J, Grabowski J, Saltzstein SL and Kane CJ: Renal cell carcinoma in the pediatric population: Results from the California Cancer Registry. Pediatr Blood Cancer. 52:237–241. 2009. View Article : Google Scholar : PubMed/NCBI

4 

González-Sánchez A, Jaraíz-Rodríguez M, Domínguez-Prieto M, Herrero-González S, Medina JM and Tabernero A: Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes. Oncotarget. 7:49819–49833. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Davis NM, Sokolosky M, Stadelman K, Abrams SL, Libra M, Candido S, Nicoletti F, Polesel J, Maestro R, D'Assoro A, et al: Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: Possibilities for therapeutic intervention. Oncotarget. 5:4603–4650. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, et al: Dual shp2 and pten deficiencies promote non-alcoholic steatohepatitis and genesis of liver tumor-initiating cells. Cell Rep. 17:2979–2993. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Gao F, Huang W, Zhang Y, Tang S, Zheng L, Ma F, Wang Y, Tang H and Li X: Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3β pathway in human colon cancer. Oncotarget. 6:38667–38680. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kwak MK, Johnson DT, Zhu C, Lee SH, Ye DW, Luong R and Sun Z: Conditional deletion of the Pten gene in the mouse prostate induces prostatic intraepithelial neoplasms at early ages but a slow progression to prostate tumors. PLoS One. 8:e534762013. View Article : Google Scholar : PubMed/NCBI

9 

Wang J, Qiu Y, Shi NW, Zhao JN, Wang YC, Jiang H and Qian HB: microRNA-21 mediates the TGF-β1-induced migration of keratinocytes via targeting PTEN. Eur Rev Med Pharmacol Sci. 20:3748–3759. 2016.PubMed/NCBI

10 

Qi Y, Liu J, Saadat S, Tian X, Han Y, Fong GH, Pandolfi PP, Lee LY and Li S: PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. 22:875–884. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Stumpf M and den Hertog J: Differential requirement for pten lipid and protein phosphatase activity during zebrafish embryonic development. PLoS One. 11:e01485082016. View Article : Google Scholar : PubMed/NCBI

12 

Stumpf M, Blokzijl-Franke S and den Hertog J: Fine-tuning of pten localization and phosphatase activity is essential for zebrafish angiogenesis. PLoS One. 11:e01547712016. View Article : Google Scholar : PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 225:402–408. 2001. View Article : Google Scholar

14 

Ragos V, Fotiades PP, Tsiambas E and Peschos D: PTEN in laryngeal carcinomas. J BUON. 21:1024–1025. 2016.PubMed/NCBI

15 

Heymont J, Berenfeld L, Collins J, Kaganovich A, Maynes B, Moulin A, Ratskovskaya I, Poon PP, Johnston GC, Kamenetsky M, et al: TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Proc Natl Acad Sci USA. 97:12672–12677. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Lu XX, Cao LY, Chen X, Xiao J, Zou Y and Chen Q: PTEN inhibits cell proliferation, promotes cell apoptosis, and induces cell cycle arrest via downregulating the PI3K/AKT/hTERT pathway in lung adenocarcinoma a549 cells. BioMed Res Int. 2016:24768422016. View Article : Google Scholar : PubMed/NCBI

17 

Wu KL, Wu CA, Wu CW, Chan SH, Chang AY and Chan JY: Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats. Antioxid Redox Signal. 18:36–50. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Shojaee S, Chan LN, Buchner M, Cazzaniga V, Cosgun KN, Geng H, Qiu YH, von Minden MD, Ernst T, Hochhaus A, et al: PTEN opposes negative selection and enables oncogenic trans-formation of pre-B cells. Nat Med. 22:379–387. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Zhang L, Yu Q, He J and Zha X: Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines. Mol Cell Biochem. 262:25–33. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Gupta A and Dey CS: PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance. Mol Biol Cell. 23:3882–3898. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Gerisch G, Schroth-Diez B, Müller-Taubenberger A and Ecke M: PIP3 waves and PTEN dynamics in the emergence of cell polarity. Biophys J. 103:1170–1178. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Ebbesen SH, Scaltriti M, Bialucha CU, Morse N, Kastenhuber ER, Wen HY, Dow LE, Baselga J and Lowe SW: Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas. Proc Natl Acad Sci USA. 113:3030–3035. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Li J, Yin LL, Su KL, Zhang GF and Wang J: Concomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer. Oncol Lett. 8:1543–1550. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Qu W, Fu JD, Yang F, Yang GL, Zhang YL, Wang XY, Gu HX, Zhang HY and Wang L: Clinical implications of PTEN andVEGF expression status, as well as microvessel density inesophageal squamous cell carcinoma. Oncol Lett. 10:1409–1415. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu H, Tan Y and Chen L: A clinical study on the expression of PTEN in renal cell carcinoma in children. Oncol Lett 17: 69-72, 2019.
APA
Lu, H., Tan, Y., & Chen, L. (2019). A clinical study on the expression of PTEN in renal cell carcinoma in children. Oncology Letters, 17, 69-72. https://doi.org/10.3892/ol.2018.9571
MLA
Lu, H., Tan, Y., Chen, L."A clinical study on the expression of PTEN in renal cell carcinoma in children". Oncology Letters 17.1 (2019): 69-72.
Chicago
Lu, H., Tan, Y., Chen, L."A clinical study on the expression of PTEN in renal cell carcinoma in children". Oncology Letters 17, no. 1 (2019): 69-72. https://doi.org/10.3892/ol.2018.9571
Copy and paste a formatted citation
x
Spandidos Publications style
Lu H, Tan Y and Chen L: A clinical study on the expression of PTEN in renal cell carcinoma in children. Oncol Lett 17: 69-72, 2019.
APA
Lu, H., Tan, Y., & Chen, L. (2019). A clinical study on the expression of PTEN in renal cell carcinoma in children. Oncology Letters, 17, 69-72. https://doi.org/10.3892/ol.2018.9571
MLA
Lu, H., Tan, Y., Chen, L."A clinical study on the expression of PTEN in renal cell carcinoma in children". Oncology Letters 17.1 (2019): 69-72.
Chicago
Lu, H., Tan, Y., Chen, L."A clinical study on the expression of PTEN in renal cell carcinoma in children". Oncology Letters 17, no. 1 (2019): 69-72. https://doi.org/10.3892/ol.2018.9571
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