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Article

Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression

  • Authors:
    • Hiroki Harada
    • Kei Hosoda
    • Hiromitsu Moriya
    • Hiroaki Mieno
    • Akira Ema
    • Marie Washio
    • Mariko Kikuchi
    • Yoshimasa Kosaka
    • Masahiko Watanabe
    • Keishi Yamashita
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0375, Japan, Department of Breast and Endocrine Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0375, Japan
  • Pages: 578-586
    |
    Published online on: October 16, 2018
       https://doi.org/10.3892/ol.2018.9585
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Abstract

Esophageal carcinosarcoma (ECS) has been suggested to result from an epithelial mesenchymal transition (EMT) phenomenon. However, knowledge on its underlying molecular features is limited. The clinical and pathological features, and the prognosis of ECS require further investigation. In the present study, a total of 325 patients with esophageal tumors were observed between January 2004 and December 2014, of which 6 patients were diagnosed pathologically with ECS. The clinicopathological features were compared with those of corresponding cases with the identical pathological T stage (pT) of esophageal squamous cell carcinoma (ESCC). In terms of the clinical T stage (cT), the 6 cases were composed of cT1, cT2, cT3 and cT4 in 1, 1, 3 and 1 case, respectively. Nevertheless, pT was eventually diagnosed as pT1 in all cases. There was a large discrepancy between clinically diagnosed depth of tumor invasion prior to surgery and depth of tumor invasion following surgery. Zinc finger E‑box‑binding homeobox 1 (ZEB1), an EMT‑associated transcription factor, was expressed only in the sarcoma component in all 6 cases of ECS. The ECS cases had a significantly poorer prognosis compared with the 115 pT1 ESCC cases. The present study suggests that the depth of invasion of ECS lesions does not correspond with their respective size, and the EMT of the carcinoma component may affect the prognosis by overexpression of the ZEB1 gene.
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1 

Virchow RL: Die Krankhalften Geschwulste. A Hirschwald, Berlin Volume. 2:pp181–182. 1865.

2 

Japan Esophageal Society, . Japanese classification of esophageal cancer, 11th edition: Part II and III. Esophagus. 14:37–65. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Kashiwabara K, Sano T, Oyama T, Najahima T, Makita F, Hashimoto N, Iwanami K, Kawashima O, Matsumoto T and Matsuzaki Y: A case of esophageal sarcomatoid carcinoma with molecular evidence of a monoclonal origin. Pathol Res Pract. 197:41–46. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Handra-Luca A, Terris B, Couvelard A, Molas G, Degott C and Flejou JF: Spindle cell squamous carcinoma of the oesophagus: An analysis of 17 cases, with new immunohistochemical evidence for a clonal origin. Histopathology. 39:125–132. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Matsumoto T, Fujii H, Arakawa A, Yamasaki S, Sonoue H, Hattori K, Kajiyama Y, Hirose S and Tsurumaru M: Loss of heterozygosity analysis shows monoclonal evolution with frequent genetic progression and divergence in esophageal carcinosarcoma. Hum Pathol. 35:322–327. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Larue L and Bellacosa A: Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 3′ kinase/AKT pathways. Oncogene. 24:7443–7454. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Nieto MA: The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol. 27:347–376. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Nakazawa T, Nobusawa S, Ikota H, Kuwano H, Takeyoshi I and Yokoo H: Wide expression of ZEB1 in sarcomatous component of spidle cell carcinoma of esophagus. Pathol Int. 65:635–643. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Brabletz S and Brabletz T: The ZEB/miR-200 feedback loop a motor of cellular plasticity in development and cancer? EMBO Rep. 11:670–677. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Lim YY, Wright JA, Attema JL, Gregory PA, Bert AG, Smith E, Thomas D, Lopez AF, Drew PA, Khew-Goodall Y and Goodall GJ: Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. J Cell Sci. 126:2256–2266. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Zhou X, Wang Y, Shan B, Han J, Zhu H, Lv Y, Fan X, Sang M, Liu XD and Liu W: The downregulation of miR200c/141 promotes ZEB1/2 expression and gastric cancer progression. Med Oncol. 32:4282015. View Article : Google Scholar : PubMed/NCBI

12 

Sobin LH and Wittekind C: TNM classification of malignant tumors. 6th. New York: Wiley-Liss; 2002

13 

Kikuchi M, Yamashita K, Waraya M, Minatani N, Ushiku H, Kojo K, Ema A, Kosaka Y, Katoh H, Sengoku N, et al: Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. Oncotarget. 7:1741–1753. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Zhu DY, Guo QS, Li YL, Cui B, Guo J, Liu JX and Li P: Twist1 correlates with poor differentiation and progression in gastric adenocarcinoma via elevation of FGFR2 expression. World J Gastroenterol. 20:18306–18315. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Sung CO, Lee KW, Han S and Kim SH: Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes. Am J Pathol. 179:1827–1838. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Dong H, Xie L, Tang C, Chen S, Liu Q, Zhang Q, Zheng W, Zheng Z and Zhang H: Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma. Clin Transi Oncol. 16:783–791. 2014. View Article : Google Scholar

17 

Yu J, Li J, Chen Y, Cao W, Lu Y, Yang J and Xing E: Snail enhances glycolysis in the epithelial-mesenchymal transition process by targeting FBP1 in gastric cancer. Cell Physiol Biochem. 43:31–38. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Owens WD, Felts JA and Spitznagel EL Jr: ASA physical status classifications: A study of consistency of ratings. Anesthesiology. 49:239–243. 1978. View Article : Google Scholar : PubMed/NCBI

19 

Dindo D, Demartines N and Clavien PA: Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 240:205–213. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Kimura H, Konishi K, Kawamura T, Nojima N, Satou T, Maeda K, Yabushita K, Kuroda Y, Tsuji M and Miwa A: Esophageal sarcomas: Report of three cases. Dig Surg. 16:244–247. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Ji F, Xu YM and Xu CF: Endoscopic polypectomy: A promising therapeutic choice for esophageal carcinosarcoma. World J Gastroenterol. 15:3448–3450. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Wang L, Lin Y, Long H, Liu H, Rao H, He Y, Rong T and Liang Y: Esophageal carcinosarcoma: A unique entity with better prognosis. Ann Surg Oncol. 20:997–1004. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Takemura M, Osugi H, Takeda N, Okuda E, Ueno M and Kinoshita H: Three cases of resected so-called carcinosarcoma of the esophagus and review of the japanese literature. J Jpn Surg Assoc. 62:659–664. 2001.(In Japanese). View Article : Google Scholar

24 

Sung CO, Choi H, Lee KW and Kim SH: Sarcomatoid carcinoma represents a complete phenotype with various pathways of epithelial mesenchymal transition. J Clin Pathol. 66:601–606. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Pang A, Carbini M, Moreira AL and Maki RG: Carcinosarcomas and related cancers: Tumors caught in the act of epithelial-mesenchymal transition. J Clin Oncol Dec. 36:210–216. 2018. View Article : Google Scholar

26 

Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, et al: Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 547:453–457. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Horiguchi K, Sakamoto K, Koinuma D, Semba K, Inoue A, Inoue S, Fujii H, Yamaguchi A, Miyazawa K, Miyazono K and Saitoh M: TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP. Oncogene. 31:3190–3201. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Joseph JV, Conroy S, Tomar T, Eggens-Meijer E, Bhat K, Copray S, Walenkamp AM, Boddeke E, Balasubramanyian V, Wagemakers M, et al: TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion. Cell Death Dis. 5:e14432014. View Article : Google Scholar : PubMed/NCBI

29 

Korpal M, Lee ES, Hu G and Kang Y: The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 283:14910–14914. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y and Goodall GJ: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 10:593–601. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Park SM, Gaur AB, Lengyel E and Peter ME: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Gene Dev. 22:894–907. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Zhang B, Xiao Q, Yang D, Li X, Hu J, Wang Y and Wang W: Spindle cell carcinoma of the esophagus: A multicenter analysis in comparison with typical squamous cell carcinoma. Medicine (Baltimore). 95:e47682016. View Article : Google Scholar : PubMed/NCBI

33 

Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M, Mikuliys W, Brabletz T, Strand D, Obrist P, et al: The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene. 26:6979–6988. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto T, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, et al: Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer. J Biol Chem. 287:7896–7906. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A, Hlubek F, Jung A, Strand D, Eger A, et al: The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res. 68:537–544. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L, Abbruzzese JL, Gallick GE, Logsdon CD, McConkey DJ and Choi W: Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res. 69:5820–5828. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Sanada Y, Hihara J, Yoshida K and Yamaguchi Y: Esophageal carcinosarcoma with intramural metastasis. Dis Esophagus. 19:119–131. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Harada H, Hosoda K, Moriya H, Mieno H, Ema A, Washio M, Kikuchi M, Kosaka Y, Watanabe M, Yamashita K, Yamashita K, et al: Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression. Oncol Lett 17: 578-586, 2019.
APA
Harada, H., Hosoda, K., Moriya, H., Mieno, H., Ema, A., Washio, M. ... Yamashita, K. (2019). Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression. Oncology Letters, 17, 578-586. https://doi.org/10.3892/ol.2018.9585
MLA
Harada, H., Hosoda, K., Moriya, H., Mieno, H., Ema, A., Washio, M., Kikuchi, M., Kosaka, Y., Watanabe, M., Yamashita, K."Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression". Oncology Letters 17.1 (2019): 578-586.
Chicago
Harada, H., Hosoda, K., Moriya, H., Mieno, H., Ema, A., Washio, M., Kikuchi, M., Kosaka, Y., Watanabe, M., Yamashita, K."Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression". Oncology Letters 17, no. 1 (2019): 578-586. https://doi.org/10.3892/ol.2018.9585
Copy and paste a formatted citation
x
Spandidos Publications style
Harada H, Hosoda K, Moriya H, Mieno H, Ema A, Washio M, Kikuchi M, Kosaka Y, Watanabe M, Yamashita K, Yamashita K, et al: Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression. Oncol Lett 17: 578-586, 2019.
APA
Harada, H., Hosoda, K., Moriya, H., Mieno, H., Ema, A., Washio, M. ... Yamashita, K. (2019). Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression. Oncology Letters, 17, 578-586. https://doi.org/10.3892/ol.2018.9585
MLA
Harada, H., Hosoda, K., Moriya, H., Mieno, H., Ema, A., Washio, M., Kikuchi, M., Kosaka, Y., Watanabe, M., Yamashita, K."Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression". Oncology Letters 17.1 (2019): 578-586.
Chicago
Harada, H., Hosoda, K., Moriya, H., Mieno, H., Ema, A., Washio, M., Kikuchi, M., Kosaka, Y., Watanabe, M., Yamashita, K."Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E‑box‑binding homeobox 1 expression". Oncology Letters 17, no. 1 (2019): 578-586. https://doi.org/10.3892/ol.2018.9585
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