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Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis

  • Authors:
    • Ying Zhang
    • Xin‑Yu Lin
    • Jiao‑Hui Zhang
    • Zheng‑Lu Xie
    • Hui Deng
    • Yi‑Fang Huang
    • Xiao‑Hong Huang
  • View Affiliations / Copyright

    Affiliations: Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 127-134
    |
    Published online on: October 17, 2018
       https://doi.org/10.3892/ol.2018.9591
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Abstract

Resistance to apoptosis is a characteristic of cancer. Curcumin has become a potential anticancer drug for its pro‑apoptotic effects, but the underlying mechanisms remain unclear. Furthermore, the Notch3‑p53 signaling axis serves an important role in cell fate. The present study was designed to investigate the antitumor effect of curcumin by the Notch3‑p53 axis in mouse myeloma P3X63Ag8 cells. The effects of curcumin on the viability of P3X63Ag8 cells were evaluated using an MTT assay. Quantitative expression of the Notch3‑p53 signaling axis‑associated genes was measured by reverse transcription‑quantitative polymerase chain reaction, and western blot analysis was used to investigate the expression of proteins. Additionally, flow cytometry was used to measure the ratio of apoptosis. The results demonstrated that curcumin could significantly inhibit cell viability. No significant pro‑apoptotic effect was observed when the concentration of curcumin was <30 µM. At 30 µM, curcumin‑treated cells exhibited an apoptotic phenomenon, and the ratio of late apoptosis increased with the concentration of curcumin, and reached 28.4 and 51.8% in the medium‑ and high‑dose groups, respectively. Curcumin inhibited the expression of Notch3, while the middle‑ and high‑dose groups promoted p53. The expression of Notch3‑responsive genes Hes family BHLH transcription factor 1 and Hes‑related family transcription factor with YRPW motif 1 were notably promoted. Curcumin treatment significantly downregulated B‑cell lymphoma‑2 (Bcl‑2) at the mRNA and protein levels, but upregulated Bcl‑2‑associated X. These data indicated that curcumin exhibited antitumor effects in mouse myeloma cells with induction of apoptosis by affecting the Notch3‑p53 signaling axis.
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1 

Zhang X, Wang R, Chen G, Dejean L and Chen QH: The Effects of curcumin-based compounds on proliferation and cell death in cervical cancer cells. Anticancer Res. 35:5293–5298. 2015.PubMed/NCBI

2 

Hu A, Huang JJ, Li RL, Lu ZY, Duan JL, Xu WH, Chen XP and Fan JP: Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1. Sci Rep. 5:134292015. View Article : Google Scholar : PubMed/NCBI

3 

Balakrishna A and Kumar MH: Evaluation of synergetic anticancer activity of berberine and curcumin on different models of A549, Hep-G2, MCF-7, jurkat, and K562 cell lines. Biomed Res Int. 2015:3546142015. View Article : Google Scholar : PubMed/NCBI

4 

Ting CY, Wang HE, Yu CC, Liu HC, Liu YC and Chiang IT: Curcumin triggers DNA damage and inhibits expression of DNA repair proteins in human lung cancer cells. Anticancer Res. 35:3867–3873. 2015.PubMed/NCBI

5 

Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M and Aggarwal BB: Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene. 21:8852–8861. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Li ZC, Zhang LM, Wang HB, Ma JX and Sun JZ: Curcumin inhibits lung cancer progression and metastasis through induction of FOXO1. Tumour Biol. 35:111–116. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Choudhuri T, Pal S, Agwarwal ML, Das T and Sa G: Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 512:334–340. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Wang L, Wang L, Song R, Shen Y, Sun Y, Gu Y, Shu Y and Xu Q: Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma. Mol Cancer Ther. 10:461–471. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Chang PY, Peng SF, Lee CY, Lu CC, Tsai SC, Shieh TM, Wu TS, Tu MG, Chen MY and Yang JS: Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells. Int J Oncol. 43:1141–1150. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Rashmi R, Santhosh Kumar TR and Karunagaran D: Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. FEBS Lett. 538:19–24. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Raab MS, Podar K, Breitkreutz I, Richardson PG and Anderson KC: Multiple myeloma. Lancet. 374:324–339. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD and Bellido T: Bidirectional notch signaling and osteocyte-derived factors in the bone marrow microenvironment promote tumor cell proliferation and bone destruction in multiple myeloma. Cancer Res. 76:1089–1100. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Terpos E, Ntanasis-Stathopoulos I, Gavriatopoulou M and Dimopoulos MA: Pathogenesis of bone disease in multiple myeloma: From bench to bedside. Blood Cancer J. 8:72018. View Article : Google Scholar : PubMed/NCBI

14 

Jundt F, Pröbsting KS, Anagnostopoulos I, Muehlinghaus G, Chatterjee M, Mathas S, Bargou RC, Manz R, Stein H and Dörken B: Jagged1-induced notch signaling drives proliferation of multiple myeloma cells. Blood. 103:3511–3515. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Artavanis-Tsakonas S, Rand MD and Lake RJ: Notch signaling: Cell fate control and signal integration in development. Science. 284:770–776. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Park JT, Chen X, Tropè CG, Davidson B, Shih IeM and Wang TL: Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. Am J Pathol. 177:1087–1094. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Dang T, Vo K, Washington K and Berlin J: The role of Notch3 signaling pathway in pancreatic cancer. J Clin Oncol. 25:21049. 2007.

18 

Zhang H, Liu L, Liu C, Pan J, Lu G, Zhou Z, Chen Z and Qian C: Notch3 overexpression enhances progression and chemoresistance of urothelial carcinoma. Oncotarget. 8:34362–34373. 2017.PubMed/NCBI

19 

Gramantieri L, Giovannini C, Lanzi A, Chieco P, Ravaioli M, Venturi A, Grazi GL and Bolondi L: Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma. Liver Int. 27:997–1007. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Konishi J, Kawaguchi KS, Vo H, Haruki N, Gonzalez A, Carbone DP and Dang TP: Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res. 67:8051–8057. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Bellavia D, Campese AF, Checquolo S, Balestri A, Biondi A, Cazzaniga G, Lendahl U, Fehling HJ, Hayday AC, Frati L, et al: Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc Natl Acad Sci USA. 99:3788–3793. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Iso T, Kedes L and Hamamori Y: HES and HERP families: Multiple effectors of the Notch signaling pathway. J Cell Physiol. 194:237–255. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Kruiswijk F, Labuschagne CF and Vousden KH: p53 in survival, death and metabolic health: A lifeguard with a licence to kill. Nat Rev Mol Cell Biol. 16:393–405. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Giovannini C, Minguzzi M, Baglioni M, Fornari F, Giannone F, Ravaioli M, Cescon M, Chieco P, Bolondi L and Gramantieri L: Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma. Oncotarget. 5:10607–10620. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Hasty P, Campisi J and Sharp ZD: Do p53 stress responses impact organismal aging? Transl Cancer Res. 5:685–691. 2016. View Article : Google Scholar

26 

Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M and Green DR: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 303:1010–1014. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Czabotar PE, Lessene G, Strasser A and Adams JM: Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy. Nat Rev Mol Cell Biol. 15:49–63. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Subramaniam D, Ponnurangam S, Ramamoorthy P, Standing D, Battafarano RJ, Anant S and Sharma P: Curcumin induces cell death in esophageal cancer cells through modulating notch signaling. PLoS One. 7:e305902012. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Igney FH and Krammer PH: Death and anti-death: Tumour resistance to apoptosis. Nat Rev Cancer. 2:277–288. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Ammon HP and Wahl MA: Pharmacology of curcuma longa. Planta Med. 57:1–7. 1991. View Article : Google Scholar : PubMed/NCBI

32 

Zhang L, Cheng X, Gao Y, Bao J, Guan H, Lu R, Yu H, Xu Q and Sun Y: Induction of ROS-independent DNA damage by curcumin leads to G2/M cell cycle arrest and apoptosis in human papillary thyroid carcinoma BCPAP cells. Food Funct. 7:315–325. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Bhullar KS, Jha A and Rupasinghe HP: Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 242:107–122. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R and Darwiche N: Cell death mechanisms of plant-derived anticancer drugs: Beyond apoptosis. Apoptosis. 20:1531–1562. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Bellavia D, Campese AF, Alesse E, Vacca A, Felli MP, Balestri A, Stoppacciaro A, Tiveron C, Tatangelo L, Giovarelli M, et al: Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 19:3337–3348. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Turner N, Lambros MB, Horlings HM, Pearson A, Sharpe R, Natrajan R, Geyer FC, van Kouwenhove M, Kreike B, Mackay A, et al: Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets. Oncogene. 29:2013–2023. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Pedrosa AR, Graça JL, Carvalho S, Peleteiro MC, Duarte A and Trindade A: Notch signaling dynamics in the adult healthy prostate and in prostatic tumor development. Prostate. 76:80–96. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Sansone P, Storci G, Giovannini C, Pandolfi S, Pianetti S, Taffurelli M, Santini D, Ceccarelli C, Chieco P and Bonafé M: p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres. Stem Cells. 25:807–815. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Bieging KT, Mello SS and Attardi LD: Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer. 14:359–370. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Giovannini C, Gramantieri L, Chieco P, Minguzzi M, Lago F, Pianetti S, Ramazzotti E, Marcu KB and Bolondi L: Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism. J Hepatol. 50:969–979. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Zhu W, Liang Q, Yang X, Yu Y, Shen X and Sun G: Combination of sorafenib and Valproic acid synergistically induces cell apoptosis and inhibits hepatocellular carcinoma growth via down-regulating Notch3 and pAkt. Am J Cancer Res. 7:2503–2514. 2017.PubMed/NCBI

42 

Chakraborty S, Das K, Saha S, Mazumdar M, Manna A, Chakraborty S, Mukherjee S, Khan P, Adhikary A, Mohanty S, et al: Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation. J Biol Chem. 289:29074–29085. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Song Y, Zhang Y, Jiang H, Zhu Y, Liu L, Feng W, Yang L, Wang Y and Li M: Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway. FEBS Open Biol. 5:656–660. 2015. View Article : Google Scholar

44 

Zweidler-McKay PA, He Y, Xu L, Rodriguez CG, Karnell FG, Carpenter AC, Aster JC, Allman D and Pear WS: Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood. 106:3898–3906. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Zaucker A, Mercurio S, Sternheim N, Talbot WS and Marlow FL: Notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish. Dis Model Mech. 6:1246–1259. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Haldar S, Negrini M, Monne M, Sabbioni S and Croce CM: Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res. 54:2095–2097. 1994.PubMed/NCBI

47 

Harn HJ, Ho LI, Liu CA, Liu GC, Lin FG, Lin JJ, Chang JY and Lee WH: Down regulation of bcl-2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissues. Histopathology. 28:317–323. 1996. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Lin XY, Zhang JH, Xie ZL, Deng H, Huang YF and Huang XH: Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis. Oncol Lett 17: 127-134, 2019.
APA
Zhang, Y., Lin, X., Zhang, J., Xie, Z., Deng, H., Huang, Y., & Huang, X. (2019). Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis. Oncology Letters, 17, 127-134. https://doi.org/10.3892/ol.2018.9591
MLA
Zhang, Y., Lin, X., Zhang, J., Xie, Z., Deng, H., Huang, Y., Huang, X."Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis". Oncology Letters 17.1 (2019): 127-134.
Chicago
Zhang, Y., Lin, X., Zhang, J., Xie, Z., Deng, H., Huang, Y., Huang, X."Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis". Oncology Letters 17, no. 1 (2019): 127-134. https://doi.org/10.3892/ol.2018.9591
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Lin XY, Zhang JH, Xie ZL, Deng H, Huang YF and Huang XH: Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis. Oncol Lett 17: 127-134, 2019.
APA
Zhang, Y., Lin, X., Zhang, J., Xie, Z., Deng, H., Huang, Y., & Huang, X. (2019). Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis. Oncology Letters, 17, 127-134. https://doi.org/10.3892/ol.2018.9591
MLA
Zhang, Y., Lin, X., Zhang, J., Xie, Z., Deng, H., Huang, Y., Huang, X."Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis". Oncology Letters 17.1 (2019): 127-134.
Chicago
Zhang, Y., Lin, X., Zhang, J., Xie, Z., Deng, H., Huang, Y., Huang, X."Apoptosis of mouse myeloma cells induced by curcumin via the Notch3‑p53 signaling axis". Oncology Letters 17, no. 1 (2019): 127-134. https://doi.org/10.3892/ol.2018.9591
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