MicroRNA‑24‑3p regulates Hodgkin's lymphoma cell proliferation, migration and invasion by targeting DEDD

Wang,Jing; Yin,Kai; Lv,Xianping; Yang,Qiankun; Shao,Ming; Liu,Xin; Sun,Hui

doi:10.3892/ol.2018.9599

MicroRNA‑24‑3p regulates Hodgkin's lymphoma cell proliferation, migration and invasion by targeting DEDD

Authors:
- Jing Wang
- Kai Yin
- Xianping Lv
- Qiankun Yang
- Ming Shao
- Xin Liu
- Hui Sun
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Affiliations: Department of Blood Transfusion, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Hematopathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: October 19, 2018 https://doi.org/10.3892/ol.2018.9599
Pages: 365-371
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hodgkin's lymphoma (HL) is a common hematologic tumor, and the incidence is increasing. At present, it is considered that miRNAs are closely related to HL. Substantial attention has been paid to the effects of miRNA on the pathophysiological process of HL. This study was focused on the potential role of miR‑24‑3p in HL by targeting DEDD. The reverse transcription-quantitative PCR (RT‑qPCR) results demonstrated that miR‑24‑3p expression was highly elevated and DEDD expression reduced inversely in HL tissues compared to adjacent tissues. According to the results of CKK‑8 assays, miR‑24‑3p was able to accelerate HL cell proliferation. In addition, the results of the Transwell assays also indicated that miR‑24‑3p promoted the invasion and migration abilities of HL cells. Moreover, the results demonstrated that miR‑24‑3p inhibited DEDD expression. Hence, the present study revealed that miR‑24‑3p could accelerate HL development through inhibiting DEDD.

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