Anticancer activity and phytochemical composition of wild Gundelia tournefortii

Abu‑Lafi,Saleh; Rayan,Baraa; Kadan,Sleman; Abu‑Lafi,Malek; Rayan,Anwar

doi:10.3892/ol.2018.9602

January-2019 Volume 17 Issue 1

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January-2019 Volume 17 Issue 1

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Article

Anticancer activity and phytochemical composition of wild Gundelia tournefortii

Authors:
- Saleh Abu‑Lafi
- Baraa Rayan
- Sleman Kadan
- Malek Abu‑Lafi
- Anwar Rayan
View Affiliations / Copyright

Affiliations: Faculty of Pharmacy, Al‑Quds University, Abu Dies, Palestine, Drug Discovery Informatics Lab, Qasemi Research Center, Al‑Qasemi Academic College, Baqa‑El‑Gharbia 30100, Israel, Faculty of Medicine, Al‑Quds University, Abu Dies, Palestine
Pages: 713-717
|
Published online on: October 19, 2018

https://doi.org/10.3892/ol.2018.9602
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Abstract

Artichoke‑like wild thistles are often used in Palestinian cuisine. One of the most commercially recognized species of these wild edible thistles is Gundelia tournefortii, a common plant in the Mediterranean region. G. tournefortii, or ‘Akoob’ in Arabic, remains uncultivated, harvested wild by local populations and considered highly valuable due to its reputed health benefits. The present study aimed to investigate the anticancer effects of G. tournefortii on the human colon carcinoma HCT‑116 cell line. Methanol and hexane extracts were identified to exert considerable antitumor activity against the HCT‑116 cancer cell line, while the aqueous extract was inactive. The phytochemical profiles of the methanol and hexane extracts were investigated using gas chromatography‑mass spectrometry. A total of 6 of the 27 natural compounds identified, including sitosterol, stigmasterol, lupeol, gitoxigenin, α‑amyrin and artemisinin, have been previously validated as being active against cancerous cells. Therefore, the presence of these phytochemicals in G. tournefortii is of importance in its role in preventing and treating cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Anticancer activity and phytochemical composition of wild Gundelia tournefortii

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