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Article

Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma

  • Authors:
    • Yingchun Zhu
    • Yunfeng Mi
    • Zheyang Wang
    • Xuewen Jia
    • Zhanping Jin
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China
  • Pages: 456-461
    |
    Published online on: October 24, 2018
       https://doi.org/10.3892/ol.2018.9615
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Abstract

Osteosarcoma is the most frequent malignant bone tumor in children and adolescents. Norcantharidin (NCTD) is a purified component from blister beetles and has been identified to exert antitumor effects in a variety of cancer types. However, the antitumor effect of NCTD in osteosarcoma remains to be elucidated. In the current study, it was first demonstrated that NCTD inhibited proliferation and induced G2/M‑phase arrest and cell apoptosis in human osteosarcoma cells. Furthermore, NCTD significantly decreased the phosphorylation of Akt and the mammalian target of rapamycin in human osteosarcoma cells. These results suggest that NCTD is a promising candidate for the treatment of osteosarcoma patients in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Mi Y, Wang Z, Jia X and Jin Z: Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma. Oncol Lett 17: 456-461, 2019.
APA
Zhu, Y., Mi, Y., Wang, Z., Jia, X., & Jin, Z. (2019). Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma. Oncology Letters, 17, 456-461. https://doi.org/10.3892/ol.2018.9615
MLA
Zhu, Y., Mi, Y., Wang, Z., Jia, X., Jin, Z."Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma". Oncology Letters 17.1 (2019): 456-461.
Chicago
Zhu, Y., Mi, Y., Wang, Z., Jia, X., Jin, Z."Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma". Oncology Letters 17, no. 1 (2019): 456-461. https://doi.org/10.3892/ol.2018.9615
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Mi Y, Wang Z, Jia X and Jin Z: Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma. Oncol Lett 17: 456-461, 2019.
APA
Zhu, Y., Mi, Y., Wang, Z., Jia, X., & Jin, Z. (2019). Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma. Oncology Letters, 17, 456-461. https://doi.org/10.3892/ol.2018.9615
MLA
Zhu, Y., Mi, Y., Wang, Z., Jia, X., Jin, Z."Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma". Oncology Letters 17.1 (2019): 456-461.
Chicago
Zhu, Y., Mi, Y., Wang, Z., Jia, X., Jin, Z."Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma". Oncology Letters 17, no. 1 (2019): 456-461. https://doi.org/10.3892/ol.2018.9615
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