An observation study of the prognostic effect of waiting times in the management of pancreatic ductal adenocarcinoma

  • Authors:
    • Rei Suzuki
    • Tadayuki Takagi
    • Takuto Hikichi
    • Mitsuru Sugimoto
    • Naoki Konno
    • Hiroyuki Asama
    • Ko Watanabe
    • Jun Nakamura
    • Shigeru Marubashi
    • Hiromasa Ohira
  • View Affiliations

  • Published online on: October 26, 2018     https://doi.org/10.3892/ol.2018.9626
  • Pages: 587-593
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an aggressive course; therefore, it was hypothesized that waiting times during disease management may serve as a prognostic factor for patients with PDAC. Data for all patients with PDAC who received treatment in Fukushima Medical University Hospital were collected. Median disease‑free survival and overall survival time were calculated using the Kaplan‑Meier method and utilized as cut‑off points to divide the patients into 2 groups: A short and a long survival group. Clinical characteristics, including waiting times, the detection‑to‑diagnosis waiting time and the diagnosis‑to‑treatment waiting time, were compared between the 2 survival groups. A total of 149 patients were included in the present study. Among the 72 patients who underwent chemotherapy, no significant differences between the 2 survival groups regarding waiting times were identified; however, the proportion of patients with locally advanced disease and the administration of combination chemotherapy were significantly associated with increased survival. Additionally, no significant differences in the waiting times between the 2 survival groups were identified when evaluating the 79 patients who underwent surgical resection. In conclusion, the results of the present study indicated that detection‑to‑diagnosis and diagnosis‑to‑treatment waiting times do not influence the prognosis of patients with PDAC.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Suzuki R, Takagi T, Hikichi T, Sugimoto M, Konno N, Asama H, Watanabe K, Nakamura J, Marubashi S, Ohira H, Ohira H, et al: An observation study of the prognostic effect of waiting times in the management of pancreatic ductal adenocarcinoma. Oncol Lett 17: 587-593, 2019
APA
Suzuki, R., Takagi, T., Hikichi, T., Sugimoto, M., Konno, N., Asama, H. ... Ohira, H. (2019). An observation study of the prognostic effect of waiting times in the management of pancreatic ductal adenocarcinoma. Oncology Letters, 17, 587-593. https://doi.org/10.3892/ol.2018.9626
MLA
Suzuki, R., Takagi, T., Hikichi, T., Sugimoto, M., Konno, N., Asama, H., Watanabe, K., Nakamura, J., Marubashi, S., Ohira, H."An observation study of the prognostic effect of waiting times in the management of pancreatic ductal adenocarcinoma". Oncology Letters 17.1 (2019): 587-593.
Chicago
Suzuki, R., Takagi, T., Hikichi, T., Sugimoto, M., Konno, N., Asama, H., Watanabe, K., Nakamura, J., Marubashi, S., Ohira, H."An observation study of the prognostic effect of waiting times in the management of pancreatic ductal adenocarcinoma". Oncology Letters 17, no. 1 (2019): 587-593. https://doi.org/10.3892/ol.2018.9626