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Review Open Access

Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review)

  • Authors:
    • Li‑Man Li
    • Huan Liu
    • Xing‑Hui Liu
    • Hong‑Bin Hu
    • Song‑Mei Liu
  • View Affiliations / Copyright

    Affiliations: Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Clinical Laboratory, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai 200135, P.R. China, Department of Blood Transfusion, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430016, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 11-22
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    Published online on: October 29, 2018
       https://doi.org/10.3892/ol.2018.9631
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Abstract

Cancer is the second leading cause of mortality worldwide. More importantly, the mortality rates for cancer are increasing. In China, lung cancer, liver cancer and gastric cancer are the top three leading causes of mortality in males, whereas lung cancer, gastric cancer and liver cancer are ranked the top three causes of mortality in females. Exosomes are extracellular vesicles that are produced and released by many different cells; these vesicles have a size range between 30 and 100 nm in diameter, and contain a lipid bilayer. Exosomes exist in various bodily fluids, contain plentiful amounts of nucleic acids and proteins, and shuttle these materials between cells to mediate the development of cancers. The present review summarizes the composition of exosomes and methods for their isolation and then intensively highlights the latest findings on the contributions of exosomal microRNAs (miRNAs) and proteins to lung cancer, liver cancer and gastric cancer. Taken together, exosomal miRNAs and proteins may be used as noninvasive, novel biomarkers for cancer diagnosis, prognosis or precision treatment owing to their ability to promote tumor progression and metastasis, and their ability to regulate the immune response and tumor cell sensitivity to chemotherapy drugs.
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Copy and paste a formatted citation
Spandidos Publications style
Li LM, Liu H, Liu XH, Hu HB and Liu SM: Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review). Oncol Lett 17: 11-22, 2019.
APA
Li, L., Liu, H., Liu, X., Hu, H., & Liu, S. (2019). Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review). Oncology Letters, 17, 11-22. https://doi.org/10.3892/ol.2018.9631
MLA
Li, L., Liu, H., Liu, X., Hu, H., Liu, S."Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review)". Oncology Letters 17.1 (2019): 11-22.
Chicago
Li, L., Liu, H., Liu, X., Hu, H., Liu, S."Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review)". Oncology Letters 17, no. 1 (2019): 11-22. https://doi.org/10.3892/ol.2018.9631
Copy and paste a formatted citation
x
Spandidos Publications style
Li LM, Liu H, Liu XH, Hu HB and Liu SM: Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review). Oncol Lett 17: 11-22, 2019.
APA
Li, L., Liu, H., Liu, X., Hu, H., & Liu, S. (2019). Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review). Oncology Letters, 17, 11-22. https://doi.org/10.3892/ol.2018.9631
MLA
Li, L., Liu, H., Liu, X., Hu, H., Liu, S."Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review)". Oncology Letters 17.1 (2019): 11-22.
Chicago
Li, L., Liu, H., Liu, X., Hu, H., Liu, S."Clinical significance of exosomal miRNAs and proteins in three human cancers with high mortality in China (Review)". Oncology Letters 17, no. 1 (2019): 11-22. https://doi.org/10.3892/ol.2018.9631
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