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Article Open Access

Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma

  • Authors:
    • Zhangwei Hu
    • Lei Wang
    • Yong Han
    • Fen Li
    • Anyuan Zheng
    • Yong Xu
    • Fei Wang
    • Bokui Xiao
    • Chen Chen
    • Zezhang Tao
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Clinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China, Research Institute of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 314-322
    |
    Published online on: October 30, 2018
       https://doi.org/10.3892/ol.2018.9642
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Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world, yet current treatment options are associated with limited success. The aim of the present study was to investigate the expression of ferritin in HNSCC and clarify whether it may serve as a biomarker for predicting HNSCC metastasis. The chemiluminescent immunoassay method was used to investigate the differences in the serum ferritin (SF) levels between patients with and without tumors, and between HNSCC with and without lymph node metastasis. The iron content and expression levels of ferritin were detected to verify the differences between tumor and normal tissues, and between HNSCC without and with lymph node metastasis. Data from the Gene Expression Omnibus (GEO) dataset was used to support the aforementioned results. No statistically significant difference in the SF level was observed between patients with and without tumors. Iron content and expression levels of ferritin heavy chain (FTH) and ferritin light chain (FTL) were higher in tumor tissues compared with normal tissues. The iron content and expression levels of SF, FTH and FTL were increased in HNSCC with metastasis compared with HNSCC without metastasis. The GEO dataset further verified the results and reported that the expression level of FTH was correlated with the prognosis of patients with HNSCC. Ferritin may not be a biomarker for the early diagnosis of HNSCC. However, an association exists between the expression level of ferritin and HNSCC cervical metastasis. SF may be a potential biomarker for predicting cervical lymph node metastasis in patients with HNSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Hu Z, Wang L, Han Y, Li F, Zheng A, Xu Y, Wang F, Xiao B, Chen C, Tao Z, Tao Z, et al: Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma. Oncol Lett 17: 314-322, 2019.
APA
Hu, Z., Wang, L., Han, Y., Li, F., Zheng, A., Xu, Y. ... Tao, Z. (2019). Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma. Oncology Letters, 17, 314-322. https://doi.org/10.3892/ol.2018.9642
MLA
Hu, Z., Wang, L., Han, Y., Li, F., Zheng, A., Xu, Y., Wang, F., Xiao, B., Chen, C., Tao, Z."Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma". Oncology Letters 17.1 (2019): 314-322.
Chicago
Hu, Z., Wang, L., Han, Y., Li, F., Zheng, A., Xu, Y., Wang, F., Xiao, B., Chen, C., Tao, Z."Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma". Oncology Letters 17, no. 1 (2019): 314-322. https://doi.org/10.3892/ol.2018.9642
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Z, Wang L, Han Y, Li F, Zheng A, Xu Y, Wang F, Xiao B, Chen C, Tao Z, Tao Z, et al: Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma. Oncol Lett 17: 314-322, 2019.
APA
Hu, Z., Wang, L., Han, Y., Li, F., Zheng, A., Xu, Y. ... Tao, Z. (2019). Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma. Oncology Letters, 17, 314-322. https://doi.org/10.3892/ol.2018.9642
MLA
Hu, Z., Wang, L., Han, Y., Li, F., Zheng, A., Xu, Y., Wang, F., Xiao, B., Chen, C., Tao, Z."Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma". Oncology Letters 17.1 (2019): 314-322.
Chicago
Hu, Z., Wang, L., Han, Y., Li, F., Zheng, A., Xu, Y., Wang, F., Xiao, B., Chen, C., Tao, Z."Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma". Oncology Letters 17, no. 1 (2019): 314-322. https://doi.org/10.3892/ol.2018.9642
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