Periostin serves an important role in the pathogenesis of oral squamous cell carcinoma

  • Authors:
    • Yuanyuan Kang
    • Xue Wang
    • Ying Zhang
    • Yan Sun
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  • Published online on: November 1, 2018     https://doi.org/10.3892/ol.2018.9660
  • Pages: 1292-1298
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Abstract

The mechanism underlying OSCC tumorigenesis remains unclear. Periostin is considered to be a prominent oncogene in various solid tumors, although its precise role in OSCC progression remains unknown. In the present study, periostin expression was examined in surgical specimens of OSCC cases, and the results were analyzed for possible correlations with clinical characteristics. In addition, the proliferation and invasiveness of OSCC cells were evaluated following transfection with a Periostin small interfering RNA or an overexpression plasmid. The results revealed that periostin levels were significantly higher in patients with OSCC as compared with those in the controls (P<0.05). In addition, periostin levels in patients with OSCC were significantly associated with permeation classification. Furthermore, periostin expression was observed to promote the proliferation and invasiveness of OSCC cells. The present results suggest that periostin is significantly involved in the pathogenesis of OSCC.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kang Y, Wang X, Zhang Y and Sun Y: Periostin serves an important role in the pathogenesis of oral squamous cell carcinoma. Oncol Lett 17: 1292-1298, 2019
APA
Kang, Y., Wang, X., Zhang, Y., & Sun, Y. (2019). Periostin serves an important role in the pathogenesis of oral squamous cell carcinoma. Oncology Letters, 17, 1292-1298. https://doi.org/10.3892/ol.2018.9660
MLA
Kang, Y., Wang, X., Zhang, Y., Sun, Y."Periostin serves an important role in the pathogenesis of oral squamous cell carcinoma". Oncology Letters 17.1 (2019): 1292-1298.
Chicago
Kang, Y., Wang, X., Zhang, Y., Sun, Y."Periostin serves an important role in the pathogenesis of oral squamous cell carcinoma". Oncology Letters 17, no. 1 (2019): 1292-1298. https://doi.org/10.3892/ol.2018.9660