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Article Open Access

Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma

  • Authors:
    • Xiao Li
    • Ming‑Zhe Wen
    • Li‑Xin Su
    • Xi‑Tao Yang
    • Yi‑Feng Han
    • Xin‑Dong Fan
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai 200011, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 981-989
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    Published online on: November 2, 2018
       https://doi.org/10.3892/ol.2018.9661
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Abstract

Kaposiform haemangioendotheliomas (KHEs) complicated by the Kasabach‑Merritt phenomenon (KMP) are rare and severe neoplastic lesions often associated with locally aggressive disease, consumption coagulopathy and high mortality rates. Current regimens have yet to achieve a satisfactory therapeutic effect. Thus, an effective and minimally invasive approach for treating complex KHE/KMP cases is necessary for clinical management. The present case series describes patients with KHE/KMP who underwent local suture ligation‑assisted percutaneous sclerotherapy to minimise surgical trauma and ensure effective treatment. Between September 2015 and September 2017, 3 consecutive patients with KHE/KMP underwent staged local suture ligation‑assisted percutaneous sclerotherapy. Of these patients, 2 presented with medical histories of corticosteroid treatment with unsatisfactory outcomes. The patients underwent a stepwise synthetic serial therapy programme consisting of percutaneous sclerotherapy and adjunctive pharmacotherapy accompanied by a suture ligation procedure. Clinical, radiological, pathological and laboratory data were analysed to evaluate the outcomes of the therapy. All patients were successfully managed with the proposed procedure. Significant relief of clinical symptoms and improvements in haematological indicators were achieved. No recurrence or complications were observed during regular follow‑up (4, 19 and 28 months). In conclusion, local suture ligation‑assisted percutaneous sclerotherapy was demonstrated to be a safe and effective treatment for KHE/KMP, being minimally invasive, involving simple manipulation and providing a clear treatment benefit in certain cases. Further studies involving larger sample sizes are required to thoroughly evaluate the procedure, which can potentially be used as a novel therapeutic option for KHE/KMP treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Wen MZ, Su LX, Yang XT, Han YF and Fan XD: Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma. Oncol Lett 17: 981-989, 2019.
APA
Li, X., Wen, M., Su, L., Yang, X., Han, Y., & Fan, X. (2019). Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma. Oncology Letters, 17, 981-989. https://doi.org/10.3892/ol.2018.9661
MLA
Li, X., Wen, M., Su, L., Yang, X., Han, Y., Fan, X."Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma". Oncology Letters 17.1 (2019): 981-989.
Chicago
Li, X., Wen, M., Su, L., Yang, X., Han, Y., Fan, X."Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma". Oncology Letters 17, no. 1 (2019): 981-989. https://doi.org/10.3892/ol.2018.9661
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wen MZ, Su LX, Yang XT, Han YF and Fan XD: Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma. Oncol Lett 17: 981-989, 2019.
APA
Li, X., Wen, M., Su, L., Yang, X., Han, Y., & Fan, X. (2019). Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma. Oncology Letters, 17, 981-989. https://doi.org/10.3892/ol.2018.9661
MLA
Li, X., Wen, M., Su, L., Yang, X., Han, Y., Fan, X."Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma". Oncology Letters 17.1 (2019): 981-989.
Chicago
Li, X., Wen, M., Su, L., Yang, X., Han, Y., Fan, X."Local suture ligation‑assisted percutaneous sclerotherapy for Kasabach‑Merritt phenomenon‑associated kaposiform haemangioendothelioma". Oncology Letters 17, no. 1 (2019): 981-989. https://doi.org/10.3892/ol.2018.9661
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