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Article

Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems

  • Authors:
    • Huihua Cao
    • Zhaoqing Tang
    • Zhan Yu
    • Qing Wang
    • Zhong Li
    • Qicheng Lu
    • Yugang Wu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Third Affiliated Hospital of Soochow University (The First People's Hospital of Changzhou), Changzhou, Jiangsu 213000, P.R. China, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
  • Pages: 1299-1305
    |
    Published online on: November 13, 2018
       https://doi.org/10.3892/ol.2018.9694
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Abstract

The log odds of positive lymph nodes (LODDS) and the metastatic lymph node ratio (MLR) staging systems have previously been demonstrated to exhibit advantages compared with the tumor‑node‑metastasis (TNM) staging system in predicting the prognosis of gastric cancer. The current study compared the prognostic significance of the newest Union for International Cancer Control Node classification with the LODDS and MLR staging systems. From September 2010 to December 2012, all medical records for patients with gastric cancer at the Third Affiliated Hospital of Soochow University were retrospectively analyzed and the clinicopathologic characteristics were reviewed. Cut‑off points were selected to divide the patients with gastric cancer into different groups. Univariate and multivariate analyses were performed to identify the prognostic risk factors for gastric cancer. The Harrell's concordance index (C‑index) was adopted to compare the prognostic value of the three staging systems. A total of 877 patients with gastric cancer who met the inclusion criteria were analyzed in the current study. The patients were classified according to the three MLR subgroups as follows: MLR0 (MLR=0), MLR1 (00.5). Based on multivariate analysis, LODDS, MLR and pathological node (pN) stage could significantly predict survival rates of patients with gastric cancer. According to the C‑index, the LODDS staging system more accurately predicted the 5‑year overall survival for patients with gastric cancer compared with the other two staging systems. In summary, the current study has identified that LODDS may be superior to the MLR and pN staging systems in predicting the prognosis of patients with gastric cancer. However MLR may exhibit advantages compared with LODDS for patients who have undergone adequate lymphadenectomies.
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Copy and paste a formatted citation
Spandidos Publications style
Cao H, Tang Z, Yu Z, Wang Q, Li Z, Lu Q and Wu Y: Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems. Oncol Lett 17: 1299-1305, 2019.
APA
Cao, H., Tang, Z., Yu, Z., Wang, Q., Li, Z., Lu, Q., & Wu, Y. (2019). Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems. Oncology Letters, 17, 1299-1305. https://doi.org/10.3892/ol.2018.9694
MLA
Cao, H., Tang, Z., Yu, Z., Wang, Q., Li, Z., Lu, Q., Wu, Y."Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems". Oncology Letters 17.1 (2019): 1299-1305.
Chicago
Cao, H., Tang, Z., Yu, Z., Wang, Q., Li, Z., Lu, Q., Wu, Y."Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems". Oncology Letters 17, no. 1 (2019): 1299-1305. https://doi.org/10.3892/ol.2018.9694
Copy and paste a formatted citation
x
Spandidos Publications style
Cao H, Tang Z, Yu Z, Wang Q, Li Z, Lu Q and Wu Y: Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems. Oncol Lett 17: 1299-1305, 2019.
APA
Cao, H., Tang, Z., Yu, Z., Wang, Q., Li, Z., Lu, Q., & Wu, Y. (2019). Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems. Oncology Letters, 17, 1299-1305. https://doi.org/10.3892/ol.2018.9694
MLA
Cao, H., Tang, Z., Yu, Z., Wang, Q., Li, Z., Lu, Q., Wu, Y."Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems". Oncology Letters 17.1 (2019): 1299-1305.
Chicago
Cao, H., Tang, Z., Yu, Z., Wang, Q., Li, Z., Lu, Q., Wu, Y."Comparison of the 8th union for international cancer control lymph node staging system for gastric cancer with two other lymph node staging systems". Oncology Letters 17, no. 1 (2019): 1299-1305. https://doi.org/10.3892/ol.2018.9694
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