Open Access

MicroRNA-153 suppresses cell invasion by targeting SNAI1 and predicts patient prognosis in glioma

  • Authors:
    • Wei Zhao
    • Chang-You Yin
    • Jing Jiang
    • Wei Kong
    • Hao Xu
    • Hongtao Zhang
  • View Affiliations

  • Published online on: November 15, 2018     https://doi.org/10.3892/ol.2018.9706
  • Pages: 1189-1195
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Glioma is the most common and rapidly progressive type of malignant primary brain tumor in adults. miR‑153 plays a major role in many malignancies; nevertheless, few studies have been conducted on glioma. The aim of the present study was to explore the role of miR‑153 and SNAI1 on invasion in glioma. Reverse transcription-quantitative PCR was employed to measure the expression levels of miR‑153 and SNAI1 mRNA. Transwell assay was utilized to calculate the capacity of invasion. Luciferase report assay was applied to detect whether SNAI1 was a target of miR‑153. miR‑153 was downregulated in glioma tissues and cells versus paracancerous tissues and normal immortalized gliocyte HEB cells. Transwell assay was used to measure whether a low expression of miR‑153 in glioma indicated inhibition of cell invasion. We verified that SNAI1 was a target of miR‑153 and had a negative association with miR‑153 detected by luciferase reporter assay. Additionally, miR‑153 suppressed cell invasive ability by regulating SNAI1 expression, whose partial function was reversed by SNAI1. miR‑153 suppressed cell invasion of glioma by directly targeting SNAI1. Thus, miR‑153/SNAI1 axis may be a novel target for cervical cancer treatment.
View Figures
View References

Related Articles

Journal Cover

January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhao W, Yin C, Jiang J, Kong W, Xu H and Zhang H: MicroRNA-153 suppresses cell invasion by targeting SNAI1 and predicts patient prognosis in glioma. Oncol Lett 17: 1189-1195, 2019
APA
Zhao, W., Yin, C., Jiang, J., Kong, W., Xu, H., & Zhang, H. (2019). MicroRNA-153 suppresses cell invasion by targeting SNAI1 and predicts patient prognosis in glioma. Oncology Letters, 17, 1189-1195. https://doi.org/10.3892/ol.2018.9706
MLA
Zhao, W., Yin, C., Jiang, J., Kong, W., Xu, H., Zhang, H."MicroRNA-153 suppresses cell invasion by targeting SNAI1 and predicts patient prognosis in glioma". Oncology Letters 17.1 (2019): 1189-1195.
Chicago
Zhao, W., Yin, C., Jiang, J., Kong, W., Xu, H., Zhang, H."MicroRNA-153 suppresses cell invasion by targeting SNAI1 and predicts patient prognosis in glioma". Oncology Letters 17, no. 1 (2019): 1189-1195. https://doi.org/10.3892/ol.2018.9706