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Article Open Access

MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1

Retraction in: /10.3892/ol.2024.14676
  • Authors:
    • Bo Liu
    • Xiandong Song
    • Zhaowei Yan
    • Hao Yang
    • Yingchao Shi
    • Jintao Wu
  • View Affiliations / Copyright

    Affiliations: Orthopedics Department Two, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China, Department of Cardiology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China, Department of Digestive Disease, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 781-788
    |
    Published online on: November 15, 2018
       https://doi.org/10.3892/ol.2018.9711
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Abstract

Increasing evidence has suggested that microRNAs (miRNAs; miRs) are extensively involved in the progression of chondrosarcoma (CHS). However, few studies have investigated the functional role of miR‑525 in CHS tissues and cells. In the present study, it was discovered that miR‑525 levels were decreased in CHS tissues and cells. Dual luciferase assays indicated that F‑spondin 1 (SPON1) is a target gene of microRNA (miR)‑525. In addition, miR‑525 overexpression suppressed SW1353 cell migration and invasion and enhanced SW1353 cell apoptosis. Increased SPON1 expression levels were identified in CHS tissues and cell lines. Furthermore, miR‑525 overexpression significantly suppressed the activation of focal adhesion kinase (FAK)/Src/phosphatidylinositol‑4,5‑bisphosphate 3‑kinase (PI3K)/protein kinase B (Akt) signaling in CHS cells; this suppression led to SPON1 silencing. In comparison, the SPON1 knockdown‑mediated inactivation of FAK/Src/PI3K/Akt signaling was inhibited by inhibiting miR‑525. In summary, the present study revealed that decreased miR‑525 levels could enhance CHS malignancy as decreased miR‑525 binding to the 3' untranslated region of SPON1 activates FAK/Src/PI3K/Akt signaling.
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1 

Stemm M, Beck C, Mannem R, Neilson J and Klein MJ: Dedifferentiated chondrosarcoma of bone with prominent rhabdoid component. Ann Diagn Pathol. 28:7–11. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Kumar R, Duran C, Amini B, Araujo DM and Wang WL: Erratum to: Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: A case report. Skeletal Radiol. 46:10012017. View Article : Google Scholar : PubMed/NCBI

3 

Kumar R, Duran C, Amini B, Araujo DM and Wang WL: Periosteal mesenchymal chondrosarcoma of the tibia with multifocal bone metastases: A case report. Skeletal Radiol. 46:995–1000. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Maki D, Mori, Teshima M, Kobayashi K, Matsumoto F, Sakai A, Okami K and Yoshimoto S: Chondrosarcoma of the hyoid bone-Report of a case and a literature review of the suitable treatment strategy. Auris Nasus Larynx. 44:629–634. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Lu Y, Li F, Xu T and Sun J: miRNA-497 negatively regulates the growth and motility of chondrosarcoma cells by targeting Cdc25A. Oncol Res. 23:155–163. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Issac B, Galoian K, Guettouche T, Navarro L and Temple HT: Genome-wide mRNA and miRNA expression data analysis to screen for markers involved in sarcomagenesis in human chondrosarcoma cell lines. Genom Data. 2:320–324. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Palmini G, Marini F and Brandi ML: What is new in the miRNA world regarding osteosarcoma and chondrosarcoma? Molecules. 22:pii: E417. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Zhang P, Li J and Song Y: MiR-129-5p inhibits proliferation and invasion of chondrosarcoma cells by regulating SOX4/Wnt/β-catenin signaling pathway. Cell Physiol Biochem. 42:242–253. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Sun X, Charbonneau C, Wei L, Chen Q and Terek RM: miR-181a targets RGS16 to promote chondrosarcoma growth, angiogenesis, and metastasis. Mol Cancer Res. 13:1347–1357. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Hromadnikova I, Kotlabova K, Ondrackova M, Pirkova P, Kestlerova A, Novotna V, Hympanova L and Krofta L: Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications. DNA Cell Biol. 34:437–457. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Hromadnikova I, Kotlabova K, Krofta L and Hron F: Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated RASSF1A, and SRY sequences. Tumour Biol. 39:10104283176975482017. View Article : Google Scholar : PubMed/NCBI

12 

Childs-Disney JL and Disney MD: Small molecule targeting of a MicroRNA associated with hepatocellular carcinoma. ACS Chem Biol. 11:375–380. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Chang H, Dong T, Ma X, Zhang T, Chen Z, Yang Z and Zhang Y: Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma. Biochem Biophys Res Commun. 464:45–50. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Hu H, Xin N, Liu J, Liu M, Wang Z, Wang W, Zhang Q and Qi J: Characterization of F-spondin in Japanese flounder (Paralichthys olivaceus) and its role in the nervous system development of teleosts. Gene. 575:623–631. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Palmer GD, Attur MG, Yang Q, Liu J, Moon P, Beier F and Abramson SB: F-spondin deficient mice have a high bone mass phenotype. PLoS One. 9:e983882014. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Bian D, Wang JY and Li J: Chondrosarcoma of the hyoid bone: A case report. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 51:621–622. 2016.(In Chinese). PubMed/NCBI

18 

Peterse EF, Cleven AH, De Jong Y, Briaire-de Bruijn I, Fletcher JA, Danen EH, Cleton-Jansen AM and Bovée JV: No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone. BMC Cancer. 16:4752016. View Article : Google Scholar : PubMed/NCBI

19 

Hobusch GM, Tiefenboeck TM, Patsch J, Krall C and Holzer G: Do patients after chondrosarcoma treatment have age-appropriate bone mineral density in the long term? Clin Orthop Relat Res. 474:1508–1515. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Chen LJ, Yang L, Cheng X, Xue YK and Chen LB: Overexpression of miR-24 is involved in the formation of hypocoagulation state after severe trauma by inhibiting the synthesis of coagulation factor X. Dis Markers. 2017:36496932017. View Article : Google Scholar : PubMed/NCBI

21 

Ren D, Yang Q, Dai Y, Guo W, Du H, Song L and Peng X: Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway. Mol Cancer. 16:1172017. View Article : Google Scholar : PubMed/NCBI

22 

Yang HC, Chu SK, Huang CL, Kuo HW, Wang SC, Liu SW, Ho IK and Liu YL: Genome-wide pharmacogenomic study on methadone maintenance treatment identifies SNP rs17180299 and multiple haplotypes on CYP2B6, SPON1, and GSG1L associated with plasma concentrations of methadone R- and S-enantiomers in heroin-dependent patients. PLoS Genet. 12:e10059102016. View Article : Google Scholar : PubMed/NCBI

23 

Shi GX, Zheng XF, Zhu C, Li B, Wang YR, Jiang SD and Jiang LS: Evidence of the role of R-spondin 1 and its receptor Lgr4 in the transmission of mechanical stimuli to biological signals for bone formation. Int J Mol Sci. 18:pii: E564. 2017. View Article : Google Scholar

24 

Heximer S and Husain M: A candidate hypertension gene: Will SPON1 hold salt and water? Circ Res. 100:940–942. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Genthe JR and Clements WK: R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways. Development. 144:590–600. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Zisman S, Marom K, Avraham O, Rinsky-Halivni L, Gai U, Kligun G, Tzarfaty-Majar V, Suzuki T and Klar A: Proteolysis and membrane capture of F-spondin generates combinatorial guidance cues from a single molecule. J Cell Biol. 178:1237–1249. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Dai W, Huang HL, Hu M, Wang SJ, He HJ, Chen NP and Li MY: microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1). Am J Cancer Res. 5:2697–2707. 2015.PubMed/NCBI

28 

Jahanshad N, Rajagopalan P, Hua X, Hibar DP, Nir TM, Toga AW, Jack CR Jr, Saykin AJ, Green RC, Weiner MW, et al: Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Proc Natl Acad Sci USA. 110:4768–4773. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Zhao XK, Yu L, Cheng ML, Che P, Lu YY, Zhang Q, Mu M, Li H, Zhu LL, Zhu JJ, et al: Focal adhesion kinase regulates hepatic stellate cell activation and liver fibrosis. Sci Rep. 7:40322017. View Article : Google Scholar : PubMed/NCBI

30 

Fan Y, Qu X, Ma Y, Liu Y and Hu X: Cbl-b promotes cell detachment via ubiquitination of focal adhesion kinase. Oncol Lett. 12:1113–1118. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Zhang H, Shao H, Golubovskaya VM, Chen H, Cance W, Adjei AA and Dy GK: Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways. Br J Cancer. 115:203–211. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Hirth S, Bühler A, Bührdel JB, Rudeck S, Dahme T, Rottbauer W and Just S: Paxillin and focal adhesion kinase (FAK) regulate cardiac contractility in the zebrafish heart. PLoS One. 11:e01503232016. View Article : Google Scholar : PubMed/NCBI

33 

Wu C, You J, Fu J, Wang X and Zhang Y: Phosphatidylinositol 3-kinase/Akt mediates integrin signaling to control RNA polymerase I transcriptional activity. Mol Cell Biol. 36:1555–1568. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Asano K, Arito M, Kurokawa MS, Omoteyama K, Okamoto K, Suematsu N, Yudoh K, Nakamura H, Beppu M and Kato T: Secretion of inflammatory factors from chondrocytes by layilin signaling. Biochem Biophys Res Commun. 452:85–90. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Cheng YC, Liang CM, Chen YP, Tsai IH, Kuo CC and Liang SM: F-spondin plays a critical role in murine neuroblastoma survival by maintaining IL-6 expression. J Neurochem. 110:947–955. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu B, Song X, Yan Z, Yang H, Shi Y and Wu J: MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1 Retraction in /10.3892/ol.2024.14676. Oncol Lett 17: 781-788, 2019.
APA
Liu, B., Song, X., Yan, Z., Yang, H., Shi, Y., & Wu, J. (2019). MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1 Retraction in /10.3892/ol.2024.14676. Oncology Letters, 17, 781-788. https://doi.org/10.3892/ol.2018.9711
MLA
Liu, B., Song, X., Yan, Z., Yang, H., Shi, Y., Wu, J."MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1 Retraction in /10.3892/ol.2024.14676". Oncology Letters 17.1 (2019): 781-788.
Chicago
Liu, B., Song, X., Yan, Z., Yang, H., Shi, Y., Wu, J."MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1 Retraction in /10.3892/ol.2024.14676". Oncology Letters 17, no. 1 (2019): 781-788. https://doi.org/10.3892/ol.2018.9711
Copy and paste a formatted citation
x
Spandidos Publications style
Liu B, Song X, Yan Z, Yang H, Shi Y and Wu J: MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1 Retraction in /10.3892/ol.2024.14676. Oncol Lett 17: 781-788, 2019.
APA
Liu, B., Song, X., Yan, Z., Yang, H., Shi, Y., & Wu, J. (2019). MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1 Retraction in /10.3892/ol.2024.14676. Oncology Letters, 17, 781-788. https://doi.org/10.3892/ol.2018.9711
MLA
Liu, B., Song, X., Yan, Z., Yang, H., Shi, Y., Wu, J."MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1 Retraction in /10.3892/ol.2024.14676". Oncology Letters 17.1 (2019): 781-788.
Chicago
Liu, B., Song, X., Yan, Z., Yang, H., Shi, Y., Wu, J."MicroRNA‑525 enhances chondrosarcoma malignancy by targeting F‑spondin 1 Retraction in /10.3892/ol.2024.14676". Oncology Letters 17, no. 1 (2019): 781-788. https://doi.org/10.3892/ol.2018.9711
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