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Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer

  • Authors:
    • Chen‑Jian Liu
    • Yuan‑Lian Zhang
    • Yun Shang
    • Bian Wu
    • En Yang
    • Yi‑Yong Luo
    • Xiao‑Ran Li
  • View Affiliations / Copyright

    Affiliations: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China, Department of General Surgery, First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1115-1127
    |
    Published online on: November 15, 2018
       https://doi.org/10.3892/ol.2018.9714
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Abstract

Intestinal bacteria are symbiotic microbiota within the human gut and are implicated in the occurrence and development of colorectal cancer (CRC). The current study investigated the changes in bacterial composition prior to and following surgery, as well as the differences in the bacterial community structure between cancer tissue and adjacent normal tissue. The diversity of the bacterial community and the composition of the bacteria were assessed. In addition, phylogenetic analysis and principle component analysis (PCA) were performed. The results revealed that cancer tissue and adjacent normal tissue exhibited similar bacterial compositions. However, a significant difference was identified in the composition of intestinal bacteria in stool samples collected from patients following surgery compared with stool samples collected prior to surgery. Each patient had their own unique intestinal bacterial community, likely due to a number of factors, including diet, genetic factors and health status. In addition, phylogenetic trees revealed that the most abundant operational taxonomic unit, 0001, was associated with Escherichia coli in all samples. Finally, PCA suggested that the bacterial community structure in all patient stools was similar following surgery. The current study provides information regarding the diversity of the intestinal bacterial community of patients with CRC and provides a basis for postoperative intestinal assessments.
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Copy and paste a formatted citation
Spandidos Publications style
Liu CJ, Zhang YL, Shang Y, Wu B, Yang E, Luo YY and Li XR: Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer. Oncol Lett 17: 1115-1127, 2019.
APA
Liu, C., Zhang, Y., Shang, Y., Wu, B., Yang, E., Luo, Y., & Li, X. (2019). Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer. Oncology Letters, 17, 1115-1127. https://doi.org/10.3892/ol.2018.9714
MLA
Liu, C., Zhang, Y., Shang, Y., Wu, B., Yang, E., Luo, Y., Li, X."Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer". Oncology Letters 17.1 (2019): 1115-1127.
Chicago
Liu, C., Zhang, Y., Shang, Y., Wu, B., Yang, E., Luo, Y., Li, X."Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer". Oncology Letters 17, no. 1 (2019): 1115-1127. https://doi.org/10.3892/ol.2018.9714
Copy and paste a formatted citation
x
Spandidos Publications style
Liu CJ, Zhang YL, Shang Y, Wu B, Yang E, Luo YY and Li XR: Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer. Oncol Lett 17: 1115-1127, 2019.
APA
Liu, C., Zhang, Y., Shang, Y., Wu, B., Yang, E., Luo, Y., & Li, X. (2019). Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer. Oncology Letters, 17, 1115-1127. https://doi.org/10.3892/ol.2018.9714
MLA
Liu, C., Zhang, Y., Shang, Y., Wu, B., Yang, E., Luo, Y., Li, X."Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer". Oncology Letters 17.1 (2019): 1115-1127.
Chicago
Liu, C., Zhang, Y., Shang, Y., Wu, B., Yang, E., Luo, Y., Li, X."Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer". Oncology Letters 17, no. 1 (2019): 1115-1127. https://doi.org/10.3892/ol.2018.9714
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