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Article

Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis

  • Authors:
    • Hiroshi Kobayashi
    • Yuki Yamada
    • Naoki Kawahara
    • Kenji Ogawa
    • Chiharu Yoshimoto
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara 634‑8522, Japan
  • Pages: 1196-1202
    |
    Published online on: November 16, 2018
       https://doi.org/10.3892/ol.2018.9721
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Abstract

Endometriosis‑associated ovarian cancer (EAOC) is a rare entity and has highly variable morphological presentations. Mural nodules can be seen in EAOC and benign ovarian endometrioma (OE), which causes a diagnostic dilemma. The differential diagnosis between early‑stage EAOC with predominantly cystic appearances and benign OE remains a challenge for physicians. This study will summarize recent knowledge of diagnosis of malignant transformation of endometriosis that have been studied through an innovative approach based on a wide array of novel technologies. Using PubMed database, we focused on the biochemical and technical advancement in the differential diagnosis of benign and malignant endometriosis. Compared with the subjects with benign OE, cyst fluid hemoglobin and iron‑related compounds levels were significantly lower in patients with EAOC. This observation opens up the possibility of early diagnosis before morphological variations are captured through ultrasonographic and magnetic resonance (MR) imaging diagnosis. The metallobiology technology offers one solution to this challenge. We discuss the noninvasive diagnosis of EAOC via various imaging methods, including electronic absorption spectroscopy, near infrared approach and MR transverse relaxometry. Special emphasis is given to recent advances in the noninvasive imaging modalities.
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1 

Kobayashi H, Sumimoto K, Kitanaka T, Yamada Y, Sado T, Sakata M, Yoshida S, Kawaguchi R, Kanayama S, Shigetomi H, et al: Ovarian endometrioma-risks factors of ovarian cancer development. Eur J Obstet Gynecol Reprod Biol. 138:187–193. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Brinton LA, Sakoda LC, Sherman ME, Frederiksen K, Kjaer SK, Graubard BI, Olsen JH and Mellemkjaer L: Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors. Cancer Epidemiol Biomarkers Prev. 14:2929–2935. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Nicklin J, Janda M, Gebski V, Jobling T, Land R, Manolitsas T, McCartney A, Nascimento M, Perrin L, Baker JF, et al: The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer. Int J Cancer. 131:885–890. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Taniguchi F, Harada T, Kobayashi H, Hayashi K, Momoeda M and Terakawa N: Clinical characteristics of patients in Japan with ovarian cancer presumably arising from ovarian endometrioma. Gynecol Obstet Invest. 77:104–110. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Tanase Y, Kawaguchi R, Takahama J and Kobayashi H: Factors that differentiate between endometriosis-associated ovarian cancer and benign ovarian endometriosis with mural nodules. Magn Reson Med Sci. 17:231–237. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Zhou Y and Hua KQ: Ovarian endometriosis: Risk factor analysis and prediction of malignant transformation. Prz Menopauzalny. 17:43–48. 2018.PubMed/NCBI

7 

Yoshimoto C, Iwabuchi T, Shigetomi H and Kobayashi H: Cyst fluid iron-related compounds as useful markers to distinguish malignant transformation from benign endometriotic cysts. Cancer Biomark. 15:493–439. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Yamaguchi K, Mandai M, Toyokuni S, Hamanishi J, Higuchi T, Takakura K and Fujii S: Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress. Clin Cancer Res. 14:32–40. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Yoshimoto C, Takahama J, Iwabuchi T, Uchikoshi M, Shigetomi H and Kobayashi H: Transverse relaxation rate of cyst fluid can predict malignant transformation of ovarian endometriosis. Magn Reson Med Sci. 16:137–145. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Nagai M, Mizusawa N, Kitagawa T and Nagatomo S: A role of heme side-chains of human hemoglobin in its function revealed by circular dichroism and resonance Raman spectroscopy. Biophys Rev. 10:271–284. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Iwabuchi T, Yoshimoto C, Shigetomi H and Kobayashi H: Cyst fluid hemoglobin species in endometriosis and its malignant transformation: The role of metallobiology. Oncol Lett. 11:3384–3388. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Oh JY, Hamm J, Xu X, Genschmer K, Zhong M, Lebensburger J, Marques MB, Kerby JD, Pittet JF, Gaggar A and Patel RP: Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices. Redox Biol. 9:167–177. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Colquhoun DA, Forkin KT, Durieux ME and Thiele RH: Ability of the Masimo pulse CO-Oximeter to detect changes in hemoglobin. J Clin Monit Comput. 26:69–73. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Lopes-Coelho F, Gouveia-Fernandes S, Gonçalves LG, Nunes C, Faustino I, Silva F, Félix A, Pereira SA and Serpa J: HNF1β drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC). Tumour Biol. 37:4813–4829. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, et al: Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell. 27:211–222. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Kawahara N, Yamada Y, Ito F, Hojo W, Iwabuchi T and Kobayashi H: Discrimination of malignant transformation from benign endometriosis using a near-infrared approach. Exp Ther Med. 15:3000–3005. 2018.PubMed/NCBI

17 

Fischer R and Harmatz PR: Non-invasive assessment of tissue iron overload. Hematology Am Soc Hematol Educ Program. 215–221. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Wood JC, Enriquez C, Ghugre N, Tyzka JM, Carson S, Nelson MD and Coates TD: MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 106:1460–1465. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Argyropoulou MI and Astrakas L: MRI evaluation of tissue iron burden in patients with beta-thalassaemia major. Pediatr Radiol. 37:1191–1200. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Verlhac S, Morel M, Bernaudin F, Béchet S, Jung C and Vasile M: Liver iron overload assessment by MRI R2* relaxometry in highly transfused pediatric patients: An agreement and reproducibility study. Diagn Interv Imaging. 96:259–264. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Arakawa N, Kobayashi H, Yonemoto N, Masuishi Y, Ino Y, Shigetomi H, Furukawa N, Ohtake N, Miyagi Y, Hirahara F, et al: Clinical Significance of tissue factor pathway inhibitor 2, a serum biomarker candidate for ovarian clear cell carcinoma. PLoS One. 11:e01656092016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi H, Yamada Y, Kawahara N, Ogawa K and Yoshimoto C: Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis. Oncol Lett 17: 1196-1202, 2019.
APA
Kobayashi, H., Yamada, Y., Kawahara, N., Ogawa, K., & Yoshimoto, C. (2019). Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis. Oncology Letters, 17, 1196-1202. https://doi.org/10.3892/ol.2018.9721
MLA
Kobayashi, H., Yamada, Y., Kawahara, N., Ogawa, K., Yoshimoto, C."Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis". Oncology Letters 17.1 (2019): 1196-1202.
Chicago
Kobayashi, H., Yamada, Y., Kawahara, N., Ogawa, K., Yoshimoto, C."Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis". Oncology Letters 17, no. 1 (2019): 1196-1202. https://doi.org/10.3892/ol.2018.9721
Copy and paste a formatted citation
x
Spandidos Publications style
Kobayashi H, Yamada Y, Kawahara N, Ogawa K and Yoshimoto C: Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis. Oncol Lett 17: 1196-1202, 2019.
APA
Kobayashi, H., Yamada, Y., Kawahara, N., Ogawa, K., & Yoshimoto, C. (2019). Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis. Oncology Letters, 17, 1196-1202. https://doi.org/10.3892/ol.2018.9721
MLA
Kobayashi, H., Yamada, Y., Kawahara, N., Ogawa, K., Yoshimoto, C."Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis". Oncology Letters 17.1 (2019): 1196-1202.
Chicago
Kobayashi, H., Yamada, Y., Kawahara, N., Ogawa, K., Yoshimoto, C."Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis". Oncology Letters 17, no. 1 (2019): 1196-1202. https://doi.org/10.3892/ol.2018.9721
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