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Review

Sirtuin 1 and oral cancer (Review)

  • Authors:
    • Shajedul Islam
    • Yoshihiro Abiko
    • Osamu Uehara
    • Itsuo Chiba
  • View Affiliations / Copyright

    Affiliations: Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Hokkaido 061‑0293, Japan, Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Hokkaido 061‑0293, Japan
  • Pages: 729-738
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    Published online on: November 16, 2018
       https://doi.org/10.3892/ol.2018.9722
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Abstract

The sirtuins (SIRTs) are a family of highly conserved histone deacetylases (HDACs) consisting of seven members (SIRT1‑SIRT7). Over the past few decades, SIRT1 has been the most extensively studied and garnered tremendous attention in the scientific community due to its emerging role in cancer biology. However, its biological role in the regulation of oral cancer is not yet fully understood. Owing to contradictory findings regarding the role of SIRT1 in oral cancer, debate about it continues. The present study discusses the biological roles and potential therapeutic implications of SIRT1 in precancerous oral lesions and oral cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Islam S, Abiko Y, Uehara O and Chiba I: Sirtuin 1 and oral cancer (Review). Oncol Lett 17: 729-738, 2019.
APA
Islam, S., Abiko, Y., Uehara, O., & Chiba, I. (2019). Sirtuin 1 and oral cancer (Review). Oncology Letters, 17, 729-738. https://doi.org/10.3892/ol.2018.9722
MLA
Islam, S., Abiko, Y., Uehara, O., Chiba, I."Sirtuin 1 and oral cancer (Review)". Oncology Letters 17.1 (2019): 729-738.
Chicago
Islam, S., Abiko, Y., Uehara, O., Chiba, I."Sirtuin 1 and oral cancer (Review)". Oncology Letters 17, no. 1 (2019): 729-738. https://doi.org/10.3892/ol.2018.9722
Copy and paste a formatted citation
x
Spandidos Publications style
Islam S, Abiko Y, Uehara O and Chiba I: Sirtuin 1 and oral cancer (Review). Oncol Lett 17: 729-738, 2019.
APA
Islam, S., Abiko, Y., Uehara, O., & Chiba, I. (2019). Sirtuin 1 and oral cancer (Review). Oncology Letters, 17, 729-738. https://doi.org/10.3892/ol.2018.9722
MLA
Islam, S., Abiko, Y., Uehara, O., Chiba, I."Sirtuin 1 and oral cancer (Review)". Oncology Letters 17.1 (2019): 729-738.
Chicago
Islam, S., Abiko, Y., Uehara, O., Chiba, I."Sirtuin 1 and oral cancer (Review)". Oncology Letters 17, no. 1 (2019): 729-738. https://doi.org/10.3892/ol.2018.9722
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