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Case Report

Conjunctival lymphomas in Japanese monozygotic twins: A case report

  • Authors:
    • Naoya Ishibashi
    • Satoshi Sugaya
    • Hiromichi Takahashi
    • Haruna Nishimaki
    • Yoko Nakanishi
    • Yoshiaki Chinen
    • Toshiya Maebayashi
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Nihon University School of Medicine, Tokyo 173‑8610, Japan, Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo 173‑8610, Japan, Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo 173‑8610, Japan, Department of Oncologic Pathology, Nihon University School of Medicine, Tokyo 173‑8610, Japan, Division of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602‑8566, Japan
  • Pages: 1313-1319
    |
    Published online on: November 16, 2018
       https://doi.org/10.3892/ol.2018.9723
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Abstract

An individual with a twin who has developed leukemia or non‑Hodgkin lymphoma (NHL) has an increased risk of developing the same disease, particularly with monozygotic twins. The few reported pairs of twins who developed NHL had similar primary sites and pathological subtypes. Here, we present the first reported cases of primary conjunctival NHL in both female monozygotic twins. Twin 1 was diagnosed with an extranodal marginal zone lymphoma (EMZL; Ann Arbor stage IE) in the right conjunctiva at 25 years old and a subsequent tumor in the left conjunctiva at 39 years, and was also histopathologically diagnosed as EMZL. No infiltration of other organs was detected and both lesions were surgically excised. At the age of 40 years, Twin 2 was diagnosed with an EMZL (Ann Arbor stage IE) in the right conjunctiva without infiltration of other organs and was treated with external beam radiation therapy rather than surgery. Complete remission was achieved in both twins; neither developed conjunctival recurrences. This study highlights the importance of examining the other, apparently healthy twin when one twin develops conjunctival lymphoma.
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Copy and paste a formatted citation
Spandidos Publications style
Ishibashi N, Sugaya S, Takahashi H, Nishimaki H, Nakanishi Y, Chinen Y and Maebayashi T: Conjunctival lymphomas in Japanese monozygotic twins: A case report. Oncol Lett 17: 1313-1319, 2019.
APA
Ishibashi, N., Sugaya, S., Takahashi, H., Nishimaki, H., Nakanishi, Y., Chinen, Y., & Maebayashi, T. (2019). Conjunctival lymphomas in Japanese monozygotic twins: A case report. Oncology Letters, 17, 1313-1319. https://doi.org/10.3892/ol.2018.9723
MLA
Ishibashi, N., Sugaya, S., Takahashi, H., Nishimaki, H., Nakanishi, Y., Chinen, Y., Maebayashi, T."Conjunctival lymphomas in Japanese monozygotic twins: A case report". Oncology Letters 17.1 (2019): 1313-1319.
Chicago
Ishibashi, N., Sugaya, S., Takahashi, H., Nishimaki, H., Nakanishi, Y., Chinen, Y., Maebayashi, T."Conjunctival lymphomas in Japanese monozygotic twins: A case report". Oncology Letters 17, no. 1 (2019): 1313-1319. https://doi.org/10.3892/ol.2018.9723
Copy and paste a formatted citation
x
Spandidos Publications style
Ishibashi N, Sugaya S, Takahashi H, Nishimaki H, Nakanishi Y, Chinen Y and Maebayashi T: Conjunctival lymphomas in Japanese monozygotic twins: A case report. Oncol Lett 17: 1313-1319, 2019.
APA
Ishibashi, N., Sugaya, S., Takahashi, H., Nishimaki, H., Nakanishi, Y., Chinen, Y., & Maebayashi, T. (2019). Conjunctival lymphomas in Japanese monozygotic twins: A case report. Oncology Letters, 17, 1313-1319. https://doi.org/10.3892/ol.2018.9723
MLA
Ishibashi, N., Sugaya, S., Takahashi, H., Nishimaki, H., Nakanishi, Y., Chinen, Y., Maebayashi, T."Conjunctival lymphomas in Japanese monozygotic twins: A case report". Oncology Letters 17.1 (2019): 1313-1319.
Chicago
Ishibashi, N., Sugaya, S., Takahashi, H., Nishimaki, H., Nakanishi, Y., Chinen, Y., Maebayashi, T."Conjunctival lymphomas in Japanese monozygotic twins: A case report". Oncology Letters 17, no. 1 (2019): 1313-1319. https://doi.org/10.3892/ol.2018.9723
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