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Article

Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis

  • Authors:
    • Marcelo Bonomi
    • Tamjeed Ahmed
    • Safoa Addo
    • Mitra Kooshki
    • Dario Palmieri
    • Beverly J. Levine
    • Jimmy Ruiz
    • Stefan Grant
    • William J. Petty
    • Pierre L. Triozzi
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The Ohio State University, Columbus, OH 43210, USA, Wake Forest University Comprehensive Cancer Center, Winston‑Salem, NC 27157, USA, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston‑Salem, NC 27157, USA, Solid Tumor Biology Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA, Division of Public Health Sciences, Wake Forest University Comprehensive Cancer Center, Medical Center Blvd, Winston‑Salem, NC 27157, USA
  • Pages: 1349-1356
    |
    Published online on: November 19, 2018
       https://doi.org/10.3892/ol.2018.9724
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Abstract

The combination of standard‑dose chemotherapy and immunotherapy has been shown to be beneficial for patients with non‑small cell lung cancer (NSCLC) with good performance status (PS). However, treatment options for patients with poor PS are limited. In the present study, the feasibility and immunological effects of low‑dose chemotherapy with carboplatin and paclitaxel combined with immunotherapy with pembrolizumab were examined in patients with metastatic NSCLC and a poor PS. Patients with advanced NSCLC and a PS of 2 were randomized to single‑agent pembrolizumab at 200 mg every 3 weeks or pembrolizumab combined with weekly carboplatin area under the curve 1 and paclitaxel 25 mg/m2. Blood for circulating immune cell phenotyping, soluble program death ligand 1 (sPD‑L1) and immune‑modulatory microRNAs (miRNAs) was collected prior to treatment and at weeks 4 and 7. Ten patients were randomized to the combination arm and 10 to the single‑agent arm. Therapy was well tolerated. Four patients discontinued carboplatin due to hypersensitivity reactions but continued pembrolizumab and paclitaxel treatments. Increases in activated CD4+ T cells and in immune‑regulatory miRNA, and decreases in myeloid derived suppressor cells were observed in the blood of patients in the combination arm and not in the single‑agent arm. Changes in circulating regulatory T cells and sPD‑L1 were not observed. Seven patients in the combination arm manifested a partial response compared with only two in the single‑agent arm. Weekly low‑dose chemotherapy carboplatin and paclitaxel was well tolerated and immunologically active when combined with pembrolizumab in patients with advanced NSCLC and a PS of 2. This combination merits further study in this patient population.
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1 

Azzoli CG, Temin S, Aliff T, Baker S Jr, Brahmer J, Johnson DH, Laskin JL, Masters G, Milton D, Nordquist L, et al: 2011 focused update of 2009 American society of clinical oncology clinical practice guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol. 29:3825–3831. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Reck M, Rodríguez-Abreu D, Robinson AG, Hui R, Csőszi T, Fülöp A, Gottfried M, Peled N, Tafreshi A, Cuffe S, et al: Pembrolizumab versus Chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med. 375:1823–1833. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, et al: Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 373:123–135. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Rittmeyer A, Barlesi F, Waterkamp D, Park K, Ciardiello F, von Pawel J, Gadgeel SM, Hida T, Kowalski DM, Dols MC, et al: Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): A phase 3, open-label, multicentre randomised controlled trial. Lancet. 389:255–265. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Rizvi NA, Hellmann MD, Brahmer JR, Juergens RA, Borghaei H, Gettinger S, Chow LQ, Gerber DE, Laurie SA, Goldman JW, et al: Nivolumab in combination with platinum-based doublet chemotherapy for first-line treatment of advanced non-small-cell lung cancer. J Clin Oncol. 34:2969–2979. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Langer CJ, Gadgeel SM, Borghaei H, Papadimitrakopoulou VA, Patnaik A, Powell SF, Gentzler RD, Martins RG, Stevenson JP, Jalal SI, et al: Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: A randomised, phase 2 cohort of the open-label KEYNOTE-021 study. Lancet Oncol. 17:1497–1508. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Sculier JP, Chansky K, Crowley JJ, Van Meerbeeck J and Goldstraw P: International Staging Committee and Participating Institutions: The impact of additional prognostic factors on survival and their relationship with the anatomical extent of disease expressed by the 6th edition of the TNM classification of malignant tumors and the proposals for the 7th edition. J Thorac Oncol. 3:457–466. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Bunn PA Jr: Chemotherapy for advanced non-small-cell lung cancer: Who, what, when, why? J Clin Oncol. 20 18 Suppl:23S–33S. 2002.PubMed/NCBI

9 

Tartarone A and Aieta M: Treatment of performance status 2 patients with advanced non-small-cell lung cancer: What we know and what we don't know. Future Oncol. 5:837–841. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Lilenbaum RC, Cashy J, Hensing TA, Young S and Cella D: Prevalence of poor performance status in lung cancer patients: Implications for research. J Thorac Oncol. 3:125–129. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Correale P, Cerretani D, Remondo C, Martellucci I, Marsili S, La Placa M, Sciandivasci A, Paolelli L, Pascucci A, Rossi M, et al: A novel metronomic chemotherapy regimen of weekly platinum and daily oral etoposide in high-risk non-small cell lung cancer patients. Oncol Rep. 16:133–140. 2006.PubMed/NCBI

12 

Bilir C, Durak S, Kızılkaya B, Hacıbekiroglu I, Nayır E and Engin H: Efficacy of metronomic vinorelbine in elderly patients with advanced non-small-cell lung cancer and poor performance status. Curr Oncol. 24:e199–e204. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zwitter M, Kovac V, Rajer M, Vrankar M and Smrdel U: Two schedules of chemotherapy for patients with non-small cell lung cancer in poor performance status: A phase II randomized trial. Anticancer Drugs. 21:662–668. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Lee KW, Lim JH, Kim JH, Lee CT and Lee JS: Weekly low-dose docetaxel for salvage chemotherapy in pretreated elderly or poor performance status patients with non-small cell lung cancer. J Korean Med Sci. 23:992–998. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Juan O, Albert A, Ordoño F, Casany R, Carañana V, Campos JM and Alberola V: Low-dose weekly paclitaxel as second-line treatment for advanced non-small cell lung cancer: A phase II study. Jpn J Clin Oncol. 32:449–454. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Hainsworth JD, Burris HA III and Greco FA: Weekly docetaxel as a single agent and in combination with gemcitabine in elderly and poor performance status patients with advanced non-small cell lung cancer. Semin Oncol. 28 3 Suppl 9:S21–S25. 2001. View Article : Google Scholar

17 

Santegoets SJ, Welters MJ and van der Burg SH: Monitoring of the immune dysfunction in cancer patients. Vaccines (Basel). 4:pii: E29. 2016.PubMed/NCBI

18 

de Biasi AR, Villena-Vargas J and Adusumilli PS: Cisplatin-induced antitumor immunomodulation: A review of preclinical and clinical evidence. Clin Cancer Res. 20:5384–5391. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Javeed A, Ashraf M, Riaz A, Ghafoor A, Afzal S and Mukhtar MM: Paclitaxel and immune system. Eur J Pharm Sci. 38:283–290. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Chang CL, Hsu YT, Wu CC, Lai YZ, Wang C, Yang YC, Wu TC and Hung CF: Dose-dense chemotherapy improves mechanisms of antitumor immune response. Cancer Res. 73:119–127. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–47. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Huang A, Zhang B, Wang B, ZAhang F, Fan KX and Guo YJ: Increased CD14(+)HLA-DR (−/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients. Cancer Immunol Immunother. 62:1439–1451. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Kamphorst AO, Pillai RN, Yang S, Nasti TH, Akondy RS, Wieland A, Sica GL, Yu K, Koenig L, Patel NT, et al: Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients. Proc Natl Acad Sci USA. 114:4993–4998. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Zhou J, Mahoney KM, Giobbie-Hurder A, Zhao F, Lee S, Liao X, Rodig S, Li J, Wu X, Butterfield LH, et al: Soluble PD-L1 as a biomarker in malignant melanoma treated with checkpoint blockade. Cancer Immunol Res. 5:480–492. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Okuma Y, Hosomi Y, Nakahara Y, Watanabe K, Sagawa Y and Homma S: High plasma levels of soluble programmed cell death ligand 1 are prognostic for reduced survival in advanced lung cancer. Lung Cancer. 104:1–6. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Zhang J, Gao J, Li Y, Nie J, Dai L, Hu W, Chen X, Han J, Ma X, Tian G, et al: Circulating PD-L1 in NSCLC patients and the correlation between the level of PD-L1 expression and the clinical characteristics. Thorac Cancer. 6:534–538. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Dronca RS, Mansfield AS, Liu X, Harrington S, Enninga EA, Kottschade LA, Koo CW, McWilliams RR, Block MS, Nevala WK, et al: Bim and soluble PD-L1 (sPD-L1) as predictive biomarkers of response to anti-PD-1 therapy in patients with melanoma and lung carcinoma. J Clin Oncol. 35 15 Suppl:S115342017. View Article : Google Scholar

29 

Paladini L, Fabris L, Bottai G, Raschioni C, Calin GA and Santarpia L: Targeting microRNAs as key modulators of tumor immune response. J Exp Clin Cancer Res. 35:1032016. View Article : Google Scholar : PubMed/NCBI

30 

Triozzi PL, Achberger S, Aldrich W, Elson P, Garcia J and Dreicer R: Differential immunologic and microRNA effects of 2 dosing regimens of recombinant human granulocyte/macrophage colony stimulating factor. J Immunother. 35:587–594. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Achberger S, Aldrich W, Tubbs R, Crabb JW, Singh AD and Triozzi PL: Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease. Mol Immunol. 58:182–186. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Chen J, Yuan L, Fan Q, Su F, Chen Y and Hu S: Adjuvant effect of docetaxel on the immune responses to influenza A H1N1 vaccine in mice. BMC Immunol. 13:362012. View Article : Google Scholar : PubMed/NCBI

33 

Yuan L, Wu L, Chen J, Wu Q and Hu S: Paclitaxel acts as an adjuvant to promote both Th1 and Th2 immune responses induced by ovalbumin in mice. Vaccine. 28:4402–4410. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Volk V, Cathomas R, Mark M, von Moos R, Klingbiel D, Brossart P and Mey U: Weekly carboplatin in combination with weekly paclitaxel in the treatment of metastatic non-small cell lung cancer: A single center 10-year experience. Support Care Cancer. 24:2119–2128. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Schuette W, Blankenburg T, Guschall W, Dittrich I, Schroeder M, Schweisfurth H, Chemaissani A, Schumann C, Dickgreber N, Appel T and Ukena D: Multicenter randomized trial for stage IIIB/IV non-small-cell lung cancer using every-3-week versus weekly paclitaxel/carboplatin. Clin Lung Cancer. 7:338–343. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Caiado J and Castells M: Presentation and diagnosis of hypersensitivity to platinum drugs. Curr Allergy Asthma Rep. 15:152015. View Article : Google Scholar : PubMed/NCBI

37 

Carthon BC, Wolchok JD, Yuan J, Kamat A, Tang Ng DS, Sun J, Ku G, Troncoso P, Logothetis CJ, Allison JP and Sharma P: Preoperative CTLA-4 blockade: Tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res. 16:2861–2871. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Ribas A, Shin DS, Zaretsky J, Frederiksen J, Cornish A, Avramis E, Seja E, Kivork C, Siebert J, Kaplan-Lefko P, et al: PD-1 blockade expands intratumoral memory T cells. Cancer Immunol Res. 4:194–203. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Weber JS, Kudchadkar RR, Yu B, Gallenstein D, Horak CE, Inzunza HD, Zhao X, Martinez AJ, Wang W, Gibney G, et al: Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma. J Clin Oncol. 31:4311–4318. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Heegaard NH, Schetter AJ, Welsh JA, Yoneda M, Bowman ED and Harris CC: Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer. Int J Cancer. 130:1378–2886. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Shen J, Todd NW, Zhang H, Yu L, Lingxiao X, Mei Y, Guarnera M, Liao J, Chou A, Lu CL, et al: Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. Lab Invest. 91:579–587. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Zheng D, Haddadin S, Wang Y, Gu LQ, Perry MC, Freter CE and Wang MX: Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int J Clin Exp Pathol. 4:575–586. 2011.PubMed/NCBI

43 

Zhu W, He J, Chen D, Zhang B, Xu L, Ma H, Liu X, Zhang Y and Le H: Expression of miR-29c, miR-93, and miR-429 as potential biomarkers for detection of early stage non-small lung cancer. PLoS One. 9:e877802014. View Article : Google Scholar : PubMed/NCBI

44 

Zhang H, Mao F, Shen T, Luo Q, Ding Z, Qian L and Huang J: Plasma miR-145, miR-20a, miR-21 and miR-223 as novel biomarkers for screening early-stage non-small cell lung cancer. Oncol Lett. 13:669–676. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Wu C, Cao Y, He Z, He J, Hu C, Duan H and Jiang J: Serum levels of miR-19b and miR-146a as prognostic biomarkers for non-small cell lung cancer. Tohoku J Exp Med. 232:85–95. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Zhou M, Liu Z, Zhao Y, Ding Y, Liu H, Xi Y, Xiong W, Li G, Lu J, Fodstad O, Riker AI and Tan M: MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem. 285:21496–21507. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Kong F, Sun C, Wang Z, Han L, Weng D, Lu Y and Chen G: miR-125b confers resistance of ovarian cancer cells to cisplatin by targeting pro-apoptotic Bcl-2 antagonist killer 1. J Huazhong Univ Sci Technolog Med Sci. 31:5432011. View Article : Google Scholar : PubMed/NCBI

48 

Liu M, Wang J, Huang H, Hou J, Zhang B and Wang A: miR-181a-Twist1 pathway in the chemoresistance of tongue squamous cell carcinoma. Biochem Biophys Res Commun. 441:364–370. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Pogribny IP, Filkowski JN, Tryndyak VP, Golubov A, Shpyleva SI and Kovalchuk O: Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. Int J Cancer. 127:1785–1794. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Boldin MP, Taganov KD, Rao DS, Yang L, Zhao JL, Kalwani M, Garcia-Flores Y, Luong M, Devrekanli A, Xu J, et al: miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med. 208:1189–1201. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Li L, Zhang J, Diao W, Wang D, Wei Y, Zhang CY and Zen K: MicroRNA-155 and MicroRNA-21 promote the expansion of functional myeloid-derived suppressor cells. J Immunol. 192:1034–1043. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Zhang M, Liu Q, Mi S, Liang X, Zhang Z, Su X, Liu J, Chen Y, Wang M, Zhang Y, et al: Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cellsby modulating STAT3 expression. J Immunol. 186:4716–4724. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Liu Q, Zhang M, Jiang X, Zhang Z, Dai L, Min S, Wu X, He Q, Liu J, Zhang Y, et al: miR-223 suppresses differentiation of tumor-induced CD11b+ Gr1+ myeloid-derived suppressor cells from bone marrow cells. Int J Cancer. 129:2662–2673. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Dooley J, Linterman MA and Liston A: MicroRNA regulation of T-cell development. Immunol Rev. 253:53–64. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Galluzzi L, Morselli E, Vitale I, Kepp O, Senovilla L, Criollo A, Servant N, Paccard C, Hupé P, Robert T, et al: miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res. 70:1793–1803. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Li H, Zhang P, Sun X, Sun Y, Shi C, Liu H and Liu X: MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells. Int J Oncol. 47:1379–1392. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Zhu M, Zhou X, Du Y, Huang Z, Zhu J, Xu J, Cheng G, Shu Y, Liu P, Zhu W and Wang T: miR-20a induces cisplatin resistance of a human gastric cancer cell line via targeting CYLD. Mol Med Rep. 14:1742–1750. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Lin HM, Castillo L, Mahon KL, Chiam K, Lee BY, Nguyen Q, Boyer MJ, Stockler MR, Pavlakis N, Marx G, et al: Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer. Br J Cancer. 110:2462–2471. 2014. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Bonomi M, Ahmed T, Addo S, Kooshki M, Palmieri D, Levine BJ, Ruiz J, Grant S, Petty WJ, Triozzi PL, Triozzi PL, et al: Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis. Oncol Lett 17: 1349-1356, 2019.
APA
Bonomi, M., Ahmed, T., Addo, S., Kooshki, M., Palmieri, D., Levine, B.J. ... Triozzi, P.L. (2019). Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis. Oncology Letters, 17, 1349-1356. https://doi.org/10.3892/ol.2018.9724
MLA
Bonomi, M., Ahmed, T., Addo, S., Kooshki, M., Palmieri, D., Levine, B. J., Ruiz, J., Grant, S., Petty, W. J., Triozzi, P. L."Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis". Oncology Letters 17.1 (2019): 1349-1356.
Chicago
Bonomi, M., Ahmed, T., Addo, S., Kooshki, M., Palmieri, D., Levine, B. J., Ruiz, J., Grant, S., Petty, W. J., Triozzi, P. L."Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis". Oncology Letters 17, no. 1 (2019): 1349-1356. https://doi.org/10.3892/ol.2018.9724
Copy and paste a formatted citation
x
Spandidos Publications style
Bonomi M, Ahmed T, Addo S, Kooshki M, Palmieri D, Levine BJ, Ruiz J, Grant S, Petty WJ, Triozzi PL, Triozzi PL, et al: Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis. Oncol Lett 17: 1349-1356, 2019.
APA
Bonomi, M., Ahmed, T., Addo, S., Kooshki, M., Palmieri, D., Levine, B.J. ... Triozzi, P.L. (2019). Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis. Oncology Letters, 17, 1349-1356. https://doi.org/10.3892/ol.2018.9724
MLA
Bonomi, M., Ahmed, T., Addo, S., Kooshki, M., Palmieri, D., Levine, B. J., Ruiz, J., Grant, S., Petty, W. J., Triozzi, P. L."Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis". Oncology Letters 17.1 (2019): 1349-1356.
Chicago
Bonomi, M., Ahmed, T., Addo, S., Kooshki, M., Palmieri, D., Levine, B. J., Ruiz, J., Grant, S., Petty, W. J., Triozzi, P. L."Circulating immune biomarkers as predictors of the response to pembrolizumab and weekly low dose carboplatin and paclitaxel in NSCLC and poor PS: An interim analysis". Oncology Letters 17, no. 1 (2019): 1349-1356. https://doi.org/10.3892/ol.2018.9724
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