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Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer

  • Authors:
    • Xiaoli Zhou
    • Lizhou Jia
    • Yangyang Sun
    • Lingyun Xu
    • Xudong Wang
    • Qi Tang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China, Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Department of Clinical Bio‑bank, Nantong University Affiliated Hospital, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1146-1152
    |
    Published online on: November 19, 2018
       https://doi.org/10.3892/ol.2018.9729
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Abstract

Sperm‑associated antigen 5 (SPAG5) is currently considered to serve a role in promoting tumor cell growth and is overexpressed in several types of human cancer. However, to the best of our knowledge, the association of SPAG5 with molecular subtypes of patients with breast cancer (BC) remains to be fully investigated. Reverse transcription‑quantitative polymerase chain reaction and immunohistochemistry on tissue microarrays were used in the current study to detect the expression levels of SPAG5 mRNA and protein, respectively, in BC. The association between SPAG5 mRNA and protein levels, and clinical characteristics and prognostic information were investigated. SPAG5 mRNA and protein levels were identified to be higher in BC tissues compared with matched adjacent nontumor tissues. High expression level of SPAG5 protein was associated with tumor size, histological grade, estrogen receptor expression, Ki‑67 expression, lymph node status, tumor‑node‑metastasis (TNM) stage and the triple‑negative BC subtype. In addition, high expression level of SPAG5 protein was associated with a poor prognosis in patients with BC. In summary, the current study suggests that SPAG5 is a novel and useful prognostic biomarker in BC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Jia L, Sun Y, Xu L, Wang X and Tang Q: Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer. Oncol Lett 17: 1146-1152, 2019.
APA
Zhou, X., Jia, L., Sun, Y., Xu, L., Wang, X., & Tang, Q. (2019). Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer. Oncology Letters, 17, 1146-1152. https://doi.org/10.3892/ol.2018.9729
MLA
Zhou, X., Jia, L., Sun, Y., Xu, L., Wang, X., Tang, Q."Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer". Oncology Letters 17.1 (2019): 1146-1152.
Chicago
Zhou, X., Jia, L., Sun, Y., Xu, L., Wang, X., Tang, Q."Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer". Oncology Letters 17, no. 1 (2019): 1146-1152. https://doi.org/10.3892/ol.2018.9729
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Jia L, Sun Y, Xu L, Wang X and Tang Q: Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer. Oncol Lett 17: 1146-1152, 2019.
APA
Zhou, X., Jia, L., Sun, Y., Xu, L., Wang, X., & Tang, Q. (2019). Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer. Oncology Letters, 17, 1146-1152. https://doi.org/10.3892/ol.2018.9729
MLA
Zhou, X., Jia, L., Sun, Y., Xu, L., Wang, X., Tang, Q."Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer". Oncology Letters 17.1 (2019): 1146-1152.
Chicago
Zhou, X., Jia, L., Sun, Y., Xu, L., Wang, X., Tang, Q."Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer". Oncology Letters 17, no. 1 (2019): 1146-1152. https://doi.org/10.3892/ol.2018.9729
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