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Review Open Access

Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review)

  • Authors:
    • Cristiana Tanase
    • Ionela Daniela Popescu
    • Ana‑Maria Enciu
    • Ancuta Augustina Gheorghisan‑Galateanu
    • Elena Codrici
    • Simona Mihai
    • Lucian Albulescu
    • Laura Necula
    • Radu Albulescu
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry‑Proteomics, ‘Victor Babes’ National Institute of Pathology, 050096 Bucharest, Romania, Department of Cellular and Molecular Medicine,‘Carol Davila’ University of Medicine and Pharmacy, 050047 Bucharest, Romania
    Copyright: © Tanase et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4060-4067
    |
    Published online on: November 19, 2018
       https://doi.org/10.3892/ol.2018.9734
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Abstract

Neoangiogenesis plays an important role in cutaneous lymphoma pathogenesis. Cutaneous T‑cell lymphoma (CTCL) is characterized by the presence of malignant T‑cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells: VEGF family, bFGF and PIGF. Tumor stroma (fibroblasts, inflammatory and immune cells) also plays a crucial role, by providing additional angiogenic factors. The angiogenic process through the VEGF‑VEGFR axis can promote survival, proliferation and metastasis via autocrine mechanisms in cutaneous lymphomas. Microvascular density (MVD) measures the neo‑vascularization of cutaneous lymphoma, generated by the response of tumor cells, proangiogenic stromal cells, and benign T/B lymphocytes within the tumor inflammatory infiltrate. Pro‑angiogenic proteins have been found to indicate the evolution and prognosis in patients with CTCL. In conclusion, anti‑angiogenic therapeutic protocols can target tumor vasculature or malignant tumor cells directly or through a large number of combinations with other drugs. The integration of proteomics into clinical practice based on high‑throughput technologies leads to the development of personalized medicine, adapting the specific biomarkers to the application of cancer‑type specific individual drug targets.
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1 

Patterson-Fortin J and Moliterno AR: Molecular pathogenesis of myeloproliferative neoplasms: Influence of age and gender. Curr Hematol Malig Rep. 12:424–431. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Kwan W and North TE: Netting novel regulators of hematopoiesis and hematologic malignancies in zebrafish. Curr Top Dev Biol. 124:125–160. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Deininger MW, Tyner JW and Solary E: Turning the tide in myelodysplastic/myeloproliferative neoplasms. Nat Rev Cancer. 17:425–440. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Swerdlow SH, Harris NL, Campo E, Pileri SA, Stein H, Jaffe ES and Thiele J: WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues. 2. 4th. IARC press; Lyon: 2017

5 

Jiang M, Bennani NN and Feldman AL: Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms. Expert Rev Hematol. 10:239–249. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, et al: The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–2390. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Matutes E: The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms. Int J Lab Hematol. 40:97–103. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, et al: Neuroendocrine factors: The missing link in non melanoma skin cancer (Review). Oncol Rep. 38:1327–1340. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Scarisbrick JJ, Hodak E, Bagot M, Stranzenbach R, Stadler R, Ortiz-Romero PL, Papadavid E, Evison F, Knobler R, Quaglino P, et al: Blood classification and blood response criteria in mycosis fungoides and Sézary syndrome using flow cytometry: Recommendations from the EORTC cutaneous lymphoma task force. Eur J Cancer. 93:47–56. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Shahrabi S, Rezaeeyan H, Ahmadzadeh A, Shahjahani M and Saki N: Bone marrow blood vessels: Normal and neoplastic niche. Oncol Rev. 10:3062016. View Article : Google Scholar : PubMed/NCBI

11 

Vacca A, Moretti S, Ribatti D, Pellegrino A, Pimpinelli N, Bianchi B, Bonifazi E, Ria R, Serio G and Dammacco F: Progression of mycosis fungoides is associated with changes in angiogenesis and expression of the matrix metalloproteinases 2 and 9. Eur J Cancer. 33:1685–1692. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Mazur G, Woźniak Z, Wróbel T, Maj J and Kuliczkowski K: Increased angiogenesis in cutaneous T-cell lymphomas. Pathol Oncol Res. 10:34–36. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Miyagaki T, Sugaya M, Oka T, Takahashi N, Kawaguchi M, Suga H, Fujita H, Yoshizaki A, Asano Y and Sato S: Placental growth factor and vascular endothelial growth factor together regulate tumour progression via increased vasculature in cutaneous T-cell lymphoma. Acta Derm Venereol. 97:586–592. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Levine AM, Tulpule A, Quinn DI, Gorospe G III, Smith DL, Hornor L, Boswell WD, Espina BM, Groshen SG, Masood R, et al: Phase I study of antisense oligonucleotide against vascular endothelial growth factor: Decrease in plasma vascular endothelial growth factor with potential clinical efficacy. J Clin Oncol. 24:1712–1719. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Zain J and O'Connor OA: Targeting histone deacetylases in the treatment of B- and T-cell malignancies. Invest New Drugs. 28:S58–S78. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Litvinov IV, Netchiporouk E, Cordeiro B, Zargham H, Pehr K, Gilbert M, Zhou Y, Moreau L, Woetmann A, Ødum N, et al: Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma. OncoImmunology. 3:e9700252014. View Article : Google Scholar : PubMed/NCBI

17 

Tanase C, Albulescu R, Codrici E, Calenic B, Popescu ID, Mihai S, Necula L, Cruceru ML and Hinescu ME: Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma. OncoTargets Ther. 8:81–90. 2014. View Article : Google Scholar

18 

Sibbesen NA, Kopp KL, Litvinov IV, Jønson L, Willerslev-Olsen A, Fredholm S, Petersen DL, Nastasi C, Krejsgaard T, Lindahl LM, et al: Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma. Oncotarget. 6:20555–20569. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Bagherani N and Smoller BR: An overview of cutaneous T cell lymphomas. F1000 Res. 5:52016. View Article : Google Scholar

20 

Kabasawa M, Sugaya M, Oka T, Takahashi N, Kawaguchi M, Suga H, Miyagaki T, Takahashi T, Shibata S, Fujita H, et al: Decreased interleukin-21 expression in skin and blood in advanced mycosis fungoides. J Dermatol. 43:819–822. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Vieyra-Garcia PA, Wei T, Naym DG, Fredholm S, Fink-Puches R, Cerroni L, Odum N, O'Malley JT, Gniadecki R and Wolf P: STAT3/5-dependent IL9 overexpression contributes to neoplastic cell survival in mycosis fungoides. Clin Cancer Res. 22:3328–3339. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Ikeda S, Kitadate A, Ito M, Abe F, Nara M, Watanabe A, Takahashi N, Miyagaki T, Sugaya M and Tagawa H: Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma. Oncotarget. 7:13563–13574. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Lauenborg B, Christensen L, Ralfkiaer U, Kopp KL, Jønson L, Dabelsteen S, Bonefeld CM, Geisler C, Gjerdrum LM, Zhang Q, et al: Malignant T-cells express lymphotoxin α and drive endothelial activation in cutaneous T-cell lymphoma. Oncotarget. 6:15235–15249. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Maj J, Jankowska-Konsur AM, Hałoń A, Woźniak Z, Plomer-Niezgoda E and Reich A: Expression of CXCR4 and CXCL12 and their correlations to the cell proliferation and angiogenesis in mycosis fungoides. Postepy Dermatol Alergol. 32:437–442. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Gallardo F, Sandoval J, Díaz-Lagares A, Garcia R, D'Altri T, González J, Alegre V, Servitje O, Crujeiras AB, Stefánsson ÓA, et al: Notch1 pathway activation results from the epigenetic abrogation of notch-related microRNAs in mycosis fungoides. J Invest Dermatol. 135:3144–3152. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Lindahl LM, Fredholm S, Joseph C, Nielsen BS, Jønson L, Willerslev-Olsen A, Gluud M, Blümel E, Petersen DL, Sibbesen N, et al: STAT5 induces miR-21 expression in cutaneous T cell lymphoma. Oncotarget. 7:45730–45744. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Abe F, Kitadate A, Ikeda S, Yamashita J, Nakanishi H, Takahashi N, Asaka C, Teshima K, Miyagaki T, Sugaya M, et al: Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma. Oncotarget. 8:7572–7585. 2017. View Article : Google Scholar : PubMed/NCBI

28 

da Silva Almeida AC, Abate F, Khiabanian H, Martinez-Escala E, Guitart J, Tensen CP, Vermeer MH, Rabadan R, Ferrando A and Palomero T: The mutational landscape of cutaneous T-cell lymphoma and Sézary syndrome. Nat Genet. 47:1465–1470. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Bosseila M, Sayed Sayed K, El-Din Sayed SS and Abd El Monaem A: Evaluation of angiogenesis in early mycosis fungoides patients: Dermoscopic and immunohistochemical study. Dermatology. 231:82–86. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Gratzinger D, Zhao S, Tibshirani RJ, Hsi ED, Hans CP, Pohlman B, Bast M, Avigdor A, Schiby G, Nagler A, et al: Prognostic significance of VEGF, VEGF receptors, and microvessel density in diffuse large B cell lymphoma treated with anthracycline-based chemotherapy. Lab Invest. 88:38–47. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Mendt M and Cardier JE: Stromal-derived factor-1 and its receptor, CXCR4, are constitutively expressed by mouse liver sinusoidal endothelial cells: Implications for the regulation of hematopoietic cell migration to the liver during extramedullary hematopoiesis. Stem Cells Dev. 21:2142–2151. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Daggett RN, Kurata M, Abe S, Onishi I, Miura K, Sawada Y, Tanizawa T and Kitagawa M: Expression dynamics of CXCL12 and CXCR4 during the progression of mycosis fungoides. Br J Dermatol. 171:722–731. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K, Ito K, Koh GY and Suda T: Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 118:149–161. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Kawaguchi M, Sugaya M, Suga H, Miyagaki T, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T and Sato S: Serum levels of angiopoietin-2, but not angiopoietin-1, are elevated in patients with erythrodermic cutaneous T-cell lymphoma. Acta Derm Venereol. 94:9–13. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Alshenawy HA: Prognostic significance of vascular endothelial growth factor, basic fibroblastic growth factor, and microvessel density and their relation to cell proliferation in B-cell non-Hodgkin's lymphoma. Ann Diagn Pathol. 14:321–327. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Lauenborg B, Litvinov IV, Zhou Y, Willerslev-Olsen A, Bonefeld CM, Nastasi C, Fredholm S, Lindahl LM, Sasseville D, Geisler C, et al: Malignant T-cells activate endothelial cells via IL-17 F. Blood Cancer J. 7:e5862017. View Article : Google Scholar : PubMed/NCBI

37 

Furudate S, Fujimura T, Kakizaki A, Kambayashi Y, Asano M, Watabe A and Aiba S: The possible interaction between periostin expressed by cancer stroma and tumor-associated macrophages in developing mycosis fungoides. Exp Dermatol. 25:107–112. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Tuzova M, Richmond J, Wolpowitz D, Curiel-Lewandrowski C, Chaney K, Kupper T and Cruikshank W: CCR4+ T-cell recruitment to the skin in mycosis fungoides: Potential contributions by thymic stromal lymphopoietin and interleukin-16. Leuk Lymphoma. 56:440–449. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Hashikawa K, Yasumoto S, Nakashima K, Arakawa F, Kiyasu J, Kimura Y, Saruta H, Nakama T, Yasuda K, Tashiro K, et al: Microarray analysis of gene expression by microdissected epidermis and dermis in mycosis fungoides and adult T-cell leukemia/lymphoma. Int J Oncol. 45:1200–1208. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Furudate S, Fujimura T, Kakizaki A, Hidaka T, Asano M and Aiba S: Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function by interferon alpha and interferon gamma. J Dermatol Sci. 83:182–189. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Fujimura T, Kambayashi Y, Fujisawa Y, Hidaka T and Aiba S: Tumor-associated macrophages: Therapeutic targets for skin cancer. Front Oncol. 8:32018. View Article : Google Scholar : PubMed/NCBI

42 

Humphrey RL, Karpetsky TP, Neuwelt EA and Levy CC: Levels of serum ribonuclease as an indicator of renal insufficiency in patients with leukemia. Cancer Res. 37:2015–2022. 1977.PubMed/NCBI

43 

Serban M, Cucu C, Mihăilescu E and Micu D: Value of ribonuclease and guanase activity for the diagnosis of leukemias. Rev Roum Med Intern. 11:319–324. 1974.PubMed/NCBI

44 

Biomarkers Definitions Working G; Biomarkers Definitions Working Group, : Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clin Pharmacol Ther. 69:89–95. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Pistol-Tanase C, Raducan E, Dima SO, Albulescu L, Alina I, Marius P, Cruceru LM, Codorean E, Neagu TM and Popescu I: Assessment of soluble angiogenic markers in pancreatic cancer. Biomarkers Med. 2:447–455. 2008. View Article : Google Scholar

46 

FDA-NIH Biomarker Working Group, : BEST (Biomarkers, EndpointS, and other Tools) Resource (Internet). Silver Spring; MA, USA: 2016

47 

Caruntu C, Boda D, Dumitrascu G, Constantin C and Neagu M: Proteomics focusing on immune markers in psoriatic arthritis. Biomarkers Med. 9:513–528. 2015. View Article : Google Scholar

48 

Neagu M, Caruntu C, Constantin C, Boda D, Zurac S, Spandidos DA and Tsatsakis AM: Chemically induced skin carcinogenesis: Updates in experimental models. (Review) Oncol Rep. 35:2516–2528. 2016. View Article : Google Scholar

49 

Mihai S, Codrici E, Popescu ID, Enciu AM, Rusu E, Zilisteanu D, Albulescu R, Anton G and Tanase C: Proteomic biomarkers panel: New insights in chronic kidney disease. Dis Markers. 2016:31852322016. View Article : Google Scholar : PubMed/NCBI

50 

Matei C, Tampa M, Caruntu C, Ion RM, Georgescu SR, Dumitrascu GR, Constantin C and Neagu M: Protein microarray for complex apoptosis monitoring of dysplastic oral keratinocytes in experimental photodynamic therapy. Biol Res. 47:332014. View Article : Google Scholar : PubMed/NCBI

51 

Tanase CP, Albulescu R and Neagu M: Application of 3D hydrogel microarrays in molecular diagnostics: Advantages and limitations. Expert Rev Mol Diagn. 11:461–464. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Caruntu C: Catecholamines increase in vitro proliferation of murine B16F10 melanoma cells. Acta Endocrinol (Bucur). 10:545–558. 2014. View Article : Google Scholar

53 

Boda D: Cellomics as integrative omics for cancer. Curr Proteomics. 10:237–245. 2013. View Article : Google Scholar

54 

Zurac S, Neagu M, Constantin C, Cioplea M, Nedelcu R, Bastian A, Popp C, Nichita L, Andrei R, Tebeica T, et al: Variations in the expression of TIMP1, TIMP2 and TIMP3 in cutaneous melanoma with regression and their possible function as prognostic predictors. Oncol Lett. 11:3354–3360. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Ion A, Popa IM, Papagheorghe LM, Lisievici C, Lupu M, Voiculescu V, Caruntu C and Boda D: Proteomic approaches to biomarker discovery in cutaneous T-cell lymphoma. Dis Markers. 2016:96024722016. View Article : Google Scholar : PubMed/NCBI

56 

Igreja C, Courinha M, Cachaço AS, Pereira T, Cabeçadas J, Da Silva MG and Dias S: Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patients. Haematologica. 92:469–477. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Schadendorf D, Matharoo-Ball B, Rees R, Ugurel S and Utikal J: Prognostic biomarkers of cutaneous malignancies - serological, immunohistochemical and proteomic approaches. Curr Cancer Ther Rev. 4:96–104. 2008. View Article : Google Scholar

58 

Hassel JC, Meier R, Joller-Jemelka H, Burg G and Dummer R: Serological immunomarkers in cutaneous T-cell lymphoma. Dermatology. 209:296–300. 2004. View Article : Google Scholar : PubMed/NCBI

59 

Moshkovskii SA, Sokolova EE, Brattseva EV, Karpova MA, Pyatnitskiy MA, Kubanova AA and Archakov AI: Proteome and cytokine serum profiling to diagnose a mycosis fungoides. Proteomics Clin Appl. 5:432–439. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Popescu I, Raducan E, Dinischiotu A and Tanase C: Applications of SELDI-TOF technology in cancer biomarkers discovery. Rom Biotechnol Lett. 15:5654–5667. 2010.

61 

Wilcox RA: Cutaneous T-cell lymphoma: 2017 update on diagnosis, risk-stratification, and management. Am J Hematol. 92:1085–1102. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Van Arnam JS, Lim MS and Elenitoba-Johnson KSJ: Novel insights into the pathogenesis of T-cell lymphomas. Blood. 131:2320–2330. 2018. View Article : Google Scholar : PubMed/NCBI

63 

Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, et al: Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat Genet. 47:1304–1315. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 350:2335–2342. 2004. View Article : Google Scholar : PubMed/NCBI

65 

Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R and Johnson DH: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 355:2542–2550. 2006. View Article : Google Scholar : PubMed/NCBI

66 

Miller KD: E2100: A phase III trial of paclitaxel versus paclitaxel/bevacizumab for metastatic breast cancer. Clin Breast Cancer. 3:421–422. 2003. View Article : Google Scholar : PubMed/NCBI

67 

Lockhart AC, Rothenberg ML, Dupont J, Cooper W, Chevalier P, Sternas L, Buzenet G, Koehler E, Sosman JA, Schwartz LH, et al: Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol. 28:207–214. 2010. View Article : Google Scholar : PubMed/NCBI

68 

D'Amato RJ, Loughnan MS, Flynn E and Folkman J: Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA. 91:4082–4085. 1994. View Article : Google Scholar : PubMed/NCBI

69 

Bagot M, Hasan B, Whittaker S, Beylot-Barry M, Knobler R, Shah E, Marreaud S, Morris S, Dalle S, Servitje O, et al: A phase III study of lenalidomide maintenance after debulking therapy in patients with advanced cutaneous T-cell lymphoma; EORTC 21081 (NCT01098656): Results and lessons learned for future trial designs. Eur J Dermatol. 27:286–294. 2017.PubMed/NCBI

70 

Neagu M, Constantin C and Zurac S: Immune parameters in the prognosis and therapy monitoring of cutaneous melanoma patients: Experience, role, and limitations. BioMed Res Int. 2013:1079402013. View Article : Google Scholar : PubMed/NCBI

71 

Ferrara N and Kerbel RS: Angiogenesis as a therapeutic target. Nature. 438:967–974. 2005. View Article : Google Scholar : PubMed/NCBI

72 

Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, Hicklin DJ, Chaplin D, Foster FS, Benezra R, et al: Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science. 313:1785–1787. 2006. View Article : Google Scholar : PubMed/NCBI

73 

Mayerhofer M, Valent P, Sperr WR, Griffin JD and Sillaber C: BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood. 100:3767–3775. 2002. View Article : Google Scholar : PubMed/NCBI

74 

Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, et al: Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med. 8:128–135. 2002. View Article : Google Scholar : PubMed/NCBI

75 

Kremer M, Sliva K, Klemke CD and Schnierle BS: Cutaneous T-cell lymphoma cells are sensitive to rapamycin. Exp Dermatol. 19:800–805. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Marzec M, Liu X, Wysocka M, Rook AH, Odum N and Wasik MA: Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells. PLoS One. 6:e248492011. View Article : Google Scholar : PubMed/NCBI

77 

Piekarz RL, Robey R, Sandor V, Bakke S, Wilson WH, Dahmoush L, Kingma DM, Turner ML, Altemus R and Bates SE: Inhibitor of histone deacetylation, depsipeptide, in the treatment of peripheral and cutaneous T-cell lymphoma: A case report. Blood. 98:2865–2868. 2001. View Article : Google Scholar : PubMed/NCBI

78 

Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J and Anderson KC: The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 61:3071–3076. 2001.PubMed/NCBI

79 

Shah JJ and Orlowski RZ: Proteasome inhibitors in the treatment of multiple myeloma. Leukemia. 23:1964–1979. 2009. View Article : Google Scholar : PubMed/NCBI

80 

Jain S, Zain J and O'Connor O: Novel therapeutic agents for cutaneous T-cell lymphoma. J Hematol Oncol. 5:242012. View Article : Google Scholar : PubMed/NCBI

81 

Buac D, Shen M, Schmitt S, Kona FR, Deshmukh R, Zhang Z, Neslund-Dudas C, Mitra B and Dou QP: From bortezomib to other inhibitors of the proteasome and beyond. Curr Pharm Des. 19:4025–4038. 2013. View Article : Google Scholar : PubMed/NCBI

82 

Orlowski RZ and Kuhn DJ: Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res. 14:1649–1657. 2008. View Article : Google Scholar : PubMed/NCBI

83 

Kozuch PS, Rocha-Lima CM, Dragovich T, Hochster H, O'Neil BH, Atiq OT, Pipas JM, Ryan DP and Lenz HJ: Bortezomib with or without irinotecan in relapsed or refractory colorectal cancer: Results from a randomized phase II study. J Clin Oncol. 26:2320–2326. 2008. View Article : Google Scholar : PubMed/NCBI

84 

Morris MJ, Kelly WK, Slovin S, Ryan C, Eicher C, Heller G and Scher HI: A phase II trial of bortezomib and prednisone for castration resistant metastatic prostate cancer. J Urol. 178:2378–2383. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Schmid P, Kühnhardt D, Kiewe P, Lehenbauer-Dehm S, Schippinger W, Greil R, Lange W, Preiss J, Niederle N, Brossart P, et al: A phase I/II study of bortezomib and capecitabine in patients with metastatic breast cancer previously treated with taxanes and/or anthracyclines. Ann Oncol. 19:871–876. 2008. View Article : Google Scholar : PubMed/NCBI

86 

Heider U, Rademacher J, Lamottke B, Mieth M, Moebs M, von Metzler I, Assaf C and Sezer O: Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in cutaneous T-cell lymphoma. Eur J Haematol. 82:440–449. 2009. View Article : Google Scholar : PubMed/NCBI

87 

Kim SJ, Yoon DH, Kang HJ, Kim JS, Park SK, Kim HJ, Lee J, Ryoo BY, Ko YH, Huh J, et al: Consortium for improving survival of lymphoma (CISL) investigators: Bortezomib in combination with CHOP as first-line treatment for patients with stage III/IV peripheral T-cell lymphomas: A multicentre, single-arm, phase 2 trial. Eur J Cancer. 48:3223–3231. 2012. View Article : Google Scholar : PubMed/NCBI

88 

Zinzani PL, Musuraca G, Tani M, Stefoni V, Marchi E, Fina M, Pellegrini C, Alinari L, Derenzini E, de Vivo A, et al: Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma. J Clin Oncol. 25:4293–4297. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tanase C, Popescu ID, Enciu AM, Gheorghisan‑Galateanu AA, Codrici E, Mihai S, Albulescu L, Necula L and Albulescu R: Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review). Oncol Lett 17: 4060-4067, 2019.
APA
Tanase, C., Popescu, I.D., Enciu, A., Gheorghisan‑Galateanu, A.A., Codrici, E., Mihai, S. ... Albulescu, R. (2019). Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review). Oncology Letters, 17, 4060-4067. https://doi.org/10.3892/ol.2018.9734
MLA
Tanase, C., Popescu, I. D., Enciu, A., Gheorghisan‑Galateanu, A. A., Codrici, E., Mihai, S., Albulescu, L., Necula, L., Albulescu, R."Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review)". Oncology Letters 17.5 (2019): 4060-4067.
Chicago
Tanase, C., Popescu, I. D., Enciu, A., Gheorghisan‑Galateanu, A. A., Codrici, E., Mihai, S., Albulescu, L., Necula, L., Albulescu, R."Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review)". Oncology Letters 17, no. 5 (2019): 4060-4067. https://doi.org/10.3892/ol.2018.9734
Copy and paste a formatted citation
x
Spandidos Publications style
Tanase C, Popescu ID, Enciu AM, Gheorghisan‑Galateanu AA, Codrici E, Mihai S, Albulescu L, Necula L and Albulescu R: Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review). Oncol Lett 17: 4060-4067, 2019.
APA
Tanase, C., Popescu, I.D., Enciu, A., Gheorghisan‑Galateanu, A.A., Codrici, E., Mihai, S. ... Albulescu, R. (2019). Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review). Oncology Letters, 17, 4060-4067. https://doi.org/10.3892/ol.2018.9734
MLA
Tanase, C., Popescu, I. D., Enciu, A., Gheorghisan‑Galateanu, A. A., Codrici, E., Mihai, S., Albulescu, L., Necula, L., Albulescu, R."Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review)". Oncology Letters 17.5 (2019): 4060-4067.
Chicago
Tanase, C., Popescu, I. D., Enciu, A., Gheorghisan‑Galateanu, A. A., Codrici, E., Mihai, S., Albulescu, L., Necula, L., Albulescu, R."Angiogenesis in cutaneous T‑cell lymphoma ‑ proteomic approaches (Review)". Oncology Letters 17, no. 5 (2019): 4060-4067. https://doi.org/10.3892/ol.2018.9734
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