Open Access

Overexpression of grainyhead‑like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma

  • Authors:
    • Gang Wang
    • Jingen Pan
    • Lu Zhang
    • Cheng Wang
  • View Affiliations

  • Published online on: November 21, 2018     https://doi.org/10.3892/ol.2018.9741
  • Pages: 1491-1496
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Recent studies have demonstrated that the abnormal expression of the grainyhead‑like transcription factor 2 (GRHL2) gene contributes to the progression and poor prognosis of cancer through multiple mechanisms, but little is known about its expression status and prognostic value in pancreatic carcinoma (PC). The aim of the present study was to investigate the expression of GRHL2 in PC and to evaluate its clinicopathological and prognostic significance. Immunohistochemistry and western blotting were used to detect the expression of GRHL2 in PC tissues and cell lines, respectively. The expression of GRHL2 was investigated in 92 PC tissue samples by immunohistochemistry. High expression of GRHL2 was significantly associated with histological differentiation (P=0.018) and lymphatic metastasis (P=0.024). A Kaplan‑Meier analysis revealed that high expression of GRHL2 was associated with worsened overall survival time (P<0.001). Multivariate analysis indicated that GRHL2 may be an independent prognostic factor for poor overall survival time (P=0.001). Additionally, western blot analysis demonstrated that the GRHL2 protein was highly expressed in PC cell lines. GRHL2 may serve an important role in the tumourigenesis of PC and serve as a potential therapeutic target for the prevention of PC progression.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang G, Pan J, Zhang L and Wang C: Overexpression of grainyhead‑like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma. Oncol Lett 17: 1491-1496, 2019.
APA
Wang, G., Pan, J., Zhang, L., & Wang, C. (2019). Overexpression of grainyhead‑like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma. Oncology Letters, 17, 1491-1496. https://doi.org/10.3892/ol.2018.9741
MLA
Wang, G., Pan, J., Zhang, L., Wang, C."Overexpression of grainyhead‑like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma". Oncology Letters 17.2 (2019): 1491-1496.
Chicago
Wang, G., Pan, J., Zhang, L., Wang, C."Overexpression of grainyhead‑like transcription factor 2 is associated with poor prognosis in human pancreatic carcinoma". Oncology Letters 17, no. 2 (2019): 1491-1496. https://doi.org/10.3892/ol.2018.9741