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The effects of Tim‑3 activation on T‑cells in gastric cancer progression

  • Authors:
    • Jiangtao Yu
    • Huanhu Zhang
    • Shengbo Sun
    • Shaowei Sun
    • Leping Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Gastrointestinal Surgery, Weihai Municipal Hospital, Weihai, Shandong 264200, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1461-1466
    |
    Published online on: November 21, 2018
       https://doi.org/10.3892/ol.2018.9743
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Abstract

The incidence of gastric cancer is high, especially in China. The present study aims to provide a novel therapeutic target for gastric cancer. Peripheral blood, cancerous and paracancerous tissues were collected from patients with gastric cancer. T‑cell immunoglobulin mucin domain‑3 (Tim‑3) expression in T‑cells was measured and the correlation between Tim‑3 expression and the T staging of gastric cancer was analyzed. The levels of T‑cell secreted interferon (IFN)‑γ and tumor necrosis factor (TNF)‑α were assessed following Tim‑3 signaling pathway activation. A nude mouse model of gastric cancer was established and Tim‑3‑stimulated T‑cells were injected into the mice to evaluate tumor growth. The results of the present study demonstrated that Tim‑3 expression levels from the paracancerous and cancerous gastric tissues were significantly increased compared with the peripheral blood, while its expression was significantly increased in cancerous compared with paracancerous gastric tissues. With the T staging of gastric cancer increasing, the expression of Tim‑3 gradually increased. The activation of the Tim‑3 signaling pathway in T‑cells may inhibit IFN‑γ and TNF‑α secretion, and the results from the nude mice tumor model demonstrated that the inhibitory effect on tumor growth by T‑cells was reduced by Tim‑3 signaling pathway activation. The expression level of Tim‑3 on the surface of tumor infiltrating T‑cells in gastric cancer tissue increases significantly and the increased Tim‑3 signaling may inhibit the function of T‑cells. The results suggest that the increased expression of Tim‑3 on T‑cells may be involved the development of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Zhang H, Sun S, Sun S and Li L: The effects of Tim‑3 activation on T‑cells in gastric cancer progression. Oncol Lett 17: 1461-1466, 2019.
APA
Yu, J., Zhang, H., Sun, S., Sun, S., & Li, L. (2019). The effects of Tim‑3 activation on T‑cells in gastric cancer progression. Oncology Letters, 17, 1461-1466. https://doi.org/10.3892/ol.2018.9743
MLA
Yu, J., Zhang, H., Sun, S., Sun, S., Li, L."The effects of Tim‑3 activation on T‑cells in gastric cancer progression". Oncology Letters 17.2 (2019): 1461-1466.
Chicago
Yu, J., Zhang, H., Sun, S., Sun, S., Li, L."The effects of Tim‑3 activation on T‑cells in gastric cancer progression". Oncology Letters 17, no. 2 (2019): 1461-1466. https://doi.org/10.3892/ol.2018.9743
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Zhang H, Sun S, Sun S and Li L: The effects of Tim‑3 activation on T‑cells in gastric cancer progression. Oncol Lett 17: 1461-1466, 2019.
APA
Yu, J., Zhang, H., Sun, S., Sun, S., & Li, L. (2019). The effects of Tim‑3 activation on T‑cells in gastric cancer progression. Oncology Letters, 17, 1461-1466. https://doi.org/10.3892/ol.2018.9743
MLA
Yu, J., Zhang, H., Sun, S., Sun, S., Li, L."The effects of Tim‑3 activation on T‑cells in gastric cancer progression". Oncology Letters 17.2 (2019): 1461-1466.
Chicago
Yu, J., Zhang, H., Sun, S., Sun, S., Li, L."The effects of Tim‑3 activation on T‑cells in gastric cancer progression". Oncology Letters 17, no. 2 (2019): 1461-1466. https://doi.org/10.3892/ol.2018.9743
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