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Article Open Access

miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases

Retraction in: /10.3892/ol.2025.14951
  • Authors:
    • Jue Liu
    • Xiaobo Zhang
    • Yuliang Huang
    • Qunfeng Zhang
    • Jianbin Zhou
    • Xiaodi Zhang
    • Xiaoxu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Joint Surgery, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1453-1460
    |
    Published online on: November 22, 2018
       https://doi.org/10.3892/ol.2018.9745
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Abstract

Cisplatin is a first‑line chemotherapy drug that is commonly used in the treatment of epithelial ovarian cancer (EOC). However, insensitivity to cisplatin markedly influences the outcomes of chemotherapy. MicroRNAs (miRNAs/miRs) have been demonstrated to modulate drug resistance in a number of types of cancer. The aim of the present study was to investigate the key miRNAs involved in modulating drug resistance in ovarian cancer cells. miR‑200b and miR‑200c were identified to be frequently deregulated in ovarian cancer. Upregulation of miR‑200b and miR‑200c promoted EOC cell death in the presence of cisplatin. Upregulation of miR‑125b‑5p significantly decreased tumor growth in combination with cisplatin in a mouse model. Significantly, miR‑200b and miR‑200c reversed cisplatin resistance by targeting DNA methyltransferases (DNMTs) (directly targeting DNMT3A/DNMT3B and indirectly targeting DNMT1 via specificity protein 1). These results indicate that miR‑200b‑ and miR‑200c‑mediated regulation of DNMTs serves a crucial function in the cellular response to cisplatin. miR‑200b‑ and miR‑200c‑mediated downregulation of DNMTs may improve chemotherapeutic efficacy by increasing the sensitivity of cancer cells and thus may have an impact on ovarian cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Zhang X, Huang Y, Zhang Q, Zhou J, Zhang X and Wang X: miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases Retraction in /10.3892/ol.2025.14951. Oncol Lett 17: 1453-1460, 2019.
APA
Liu, J., Zhang, X., Huang, Y., Zhang, Q., Zhou, J., Zhang, X., & Wang, X. (2019). miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases Retraction in /10.3892/ol.2025.14951. Oncology Letters, 17, 1453-1460. https://doi.org/10.3892/ol.2018.9745
MLA
Liu, J., Zhang, X., Huang, Y., Zhang, Q., Zhou, J., Zhang, X., Wang, X."miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases Retraction in /10.3892/ol.2025.14951". Oncology Letters 17.2 (2019): 1453-1460.
Chicago
Liu, J., Zhang, X., Huang, Y., Zhang, Q., Zhou, J., Zhang, X., Wang, X."miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases Retraction in /10.3892/ol.2025.14951". Oncology Letters 17, no. 2 (2019): 1453-1460. https://doi.org/10.3892/ol.2018.9745
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Zhang X, Huang Y, Zhang Q, Zhou J, Zhang X and Wang X: miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases Retraction in /10.3892/ol.2025.14951. Oncol Lett 17: 1453-1460, 2019.
APA
Liu, J., Zhang, X., Huang, Y., Zhang, Q., Zhou, J., Zhang, X., & Wang, X. (2019). miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases Retraction in /10.3892/ol.2025.14951. Oncology Letters, 17, 1453-1460. https://doi.org/10.3892/ol.2018.9745
MLA
Liu, J., Zhang, X., Huang, Y., Zhang, Q., Zhou, J., Zhang, X., Wang, X."miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases Retraction in /10.3892/ol.2025.14951". Oncology Letters 17.2 (2019): 1453-1460.
Chicago
Liu, J., Zhang, X., Huang, Y., Zhang, Q., Zhou, J., Zhang, X., Wang, X."miR‑200b and miR‑200c co‑contribute to the cisplatin sensitivity of ovarian cancer cells by targeting DNA methyltransferases Retraction in /10.3892/ol.2025.14951". Oncology Letters 17, no. 2 (2019): 1453-1460. https://doi.org/10.3892/ol.2018.9745
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