1
|
Bosetti C, Turati F and La Vecchia C:
Hepatocellular carcinoma epidemiology. Best Pract Res Clin
Gastroenterol. 28:753–770. 2014. View Article : Google Scholar : PubMed/NCBI
|
2
|
Schwartz M, Roayaie S and Konstadoulakis
M: Strategies for the management of hepatocellular carcinoma. Nat
Clin Pract Oncol. 4:424–432. 2007. View Article : Google Scholar : PubMed/NCBI
|
3
|
Trevisani F, Cantarini MC, Wands JR and
Bernardi M: Recent advances in the natural history of
hepatocellular carcinoma. Carcinogenesis. 29:1299–1305. 2008.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Daniele B, Bencivenga A, Megna AS and
Tinessa V: Alpha-fetoprotein and ultrasonography screening for
hepatocellular carcinoma. Gastroenterology. 127 (5 Suppl
1):S108–S112. 2004. View Article : Google Scholar : PubMed/NCBI
|
5
|
Li JJ, Luo J, Lu JN, Liang XN, Luo YH, Liu
YR, Yang J, Ding H, Qin GH, Yang LH, et al: Relationship between
TRAF6 and deterioration of HCC: An immunohistochemical and in vitro
study. Cancer Cell Int. 16:762016. View Article : Google Scholar : PubMed/NCBI
|
6
|
Luo Y, Ren F, Liu Y, Shi Z, Tan Z, Xiong
H, Dang Y and Chen G: Clinicopathological and prognostic
significance of high Ki-67 labeling index in hepatocellular
carcinoma patients: A meta-analysis. Int J Clin Exp Med.
8:10235–10247. 2015.PubMed/NCBI
|
7
|
Huang Z, Huang L, Shen S, Li J, Lu H, Mo
W, Dang Y, Luo D, Chen G and Feng Z: Sp1 cooperates with Sp3 to
upregulate MALAT1 expression in human hepatocellular carcinoma.
Oncol Rep. 34:2403–2412. 2015. View Article : Google Scholar : PubMed/NCBI
|
8
|
Zhang X, Tang W, Li R, He R, Gan T, Luo Y,
Chen G and Rong M: Downregulation of microRNA-132 indicates
progression in hepatocellular carcinoma. Exp Ther Med.
12:2095–2101. 2016. View Article : Google Scholar : PubMed/NCBI
|
9
|
Huang WT, Wang HL, Yang H, Ren FH, Luo YH,
Huang CQ, Liang YY, Liang HW, Chen G and Dang YW: Lower expressed
miR-198 and its potential targets in hepatocellular carcinoma: A
clinicopathological and in silico study. Onco Targets Ther.
9:5163–5180. 2016. View Article : Google Scholar : PubMed/NCBI
|
10
|
Zhang X, Tang W, Chen G, Ren F, Liang H,
Dang Y and Rong M: An encapsulation of gene signatures for
hepatocellular carcinoma, MicroRNA-132 predicted target genes and
the corresponding overlaps. PLoS One. 11:e01594982016. View Article : Google Scholar : PubMed/NCBI
|
11
|
He R, Yang L, Lin X, Chen X, Lin X, Wei F,
Liang X, Luo Y, Wu Y, Gan T, et al: MiR-30a-5p suppresses cell
growth and enhances apoptosis of hepatocellular carcinoma cells via
targeting AEG-1. Int J Clin Exp Pathol. 8:15632–15641.
2015.PubMed/NCBI
|
12
|
Liu Y, Ren F, Luo Y, Rong M, Chen G and
Dang Y: Down-regulation of MiR-193a-3p dictates deterioration of
HCC: A clinical real-time qRT-PCR study. Med Sci Monit.
21:2352–2360. 2015. View Article : Google Scholar : PubMed/NCBI
|
13
|
Huang YH, Lin KH, Chen HC, Chang ML, Hsu
CW, Lai MW, Chen TC, Lee WC, Tseng YH and Yeh CT: Identification of
postoperative prognostic microRNA predictors in hepatocellular
carcinoma. PLoS One. 7:e371882012. View Article : Google Scholar : PubMed/NCBI
|
14
|
Hung CH, Hu TH, Lu SN, Kuo FY, Chen CH,
Wang JH, Huang CM, Lee CM, Lin CY, Yen YH and Chiu YC: Circulating
microRNAs as biomarkers for diagnosis of early hepatocellular
carcinoma associated with hepatitis B virus. Int J Cancer.
138:714–720. 2016. View Article : Google Scholar : PubMed/NCBI
|
15
|
Liu AM, Yao TJ, Wang W, Wong KF, Lee NP,
Fan ST, Poon RT, Gao C and Luk JM: Circulating miR-15b and miR-130b
in serum as potential markers for detecting hepatocellular
carcinoma: A retrospective cohort study. BMJ Open. 2:e0008252012.
View Article : Google Scholar : PubMed/NCBI
|
16
|
Chen Y, Chen J, Liu Y, Li S and Huang P:
Plasma miR-15b-5p, miR-338-5p, and miR-764 as biomarkers for
hepatocellular carcinoma. Med Sci Monit. 21:1864–1871. 2015.
View Article : Google Scholar : PubMed/NCBI
|
17
|
Zhang Y, Dang YW, Wang X, Yang X, Zhang R,
Lv ZL and Chen G: Comprehensive analysis of long non-coding RNA
PVT1 gene interaction regulatory network in hepatocellular
carcinoma using gene microarray and bioinformatics. Am J Transl
Res. 9:3904–3917. 2017.PubMed/NCBI
|
18
|
Zhang Y, He RQ, Dang YW, Zhang XL, Wang X,
Huang SN, Huang WT, Jiang MT, Gan XN, Xie Y, et al: Comprehensive
analysis of the long noncoding RNA HOXA11-AS gene interaction
regulatory network in NSCLC cells. Cancer Cell Int. 16:892016.
View Article : Google Scholar : PubMed/NCBI
|
19
|
Kew MC: Epidemiology of chronic hepatitis
B virus infection, hepatocellular carcinoma, and hepatitis B
virus-induced hepatocellular carcinoma. Pathol Biol (Paris).
58:273–277. 2010. View Article : Google Scholar : PubMed/NCBI
|
20
|
Murakami Y, Kubo S, Tamori A, Itami S,
Kawamura E, Iwaisako K, Ikeda K, Kawada N, Ochiya T and Taguchi YH:
Comprehensive analysis of transcriptome and metabolome analysis in
Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma. Sci
Rep. 5:162942015. View Article : Google Scholar : PubMed/NCBI
|
21
|
Shen J, LeFave C, Sirosh I, Siegel AB,
Tycko B and Santella RM: Integrative epigenomic and genomic
filtering for methylation markers in hepatocellular carcinomas. BMC
Med Genomics. 8:282015. View Article : Google Scholar : PubMed/NCBI
|
22
|
Sato F, Hatano E, Kitamura K, Myomoto A,
Fujiwara T, Takizawa S, Tsuchiya S, Tsujimoto G, Uemoto S and
Shimizu K: MicroRNA profile predicts recurrence after resection in
patients with hepatocellular carcinoma within the Milan Criteria.
PLoS One. 6:e164352011. View Article : Google Scholar : PubMed/NCBI
|
23
|
Burchard J, Zhang C, Liu AM, Poon RT, Lee
NP, Wong KF, Sham PC, Lam BY, Ferguson MD, Tokiwa G, et al:
microRNA-122 as a regulator of mitochondrial metabolic gene network
in hepatocellular carcinoma. Mol Syst Biol. 6:4022010. View Article : Google Scholar : PubMed/NCBI
|
24
|
Li W, Xie L, He X, Li J, Tu K, Wei L, Wu
J, Guo Y, Ma X, Zhang P, et al: Diagnostic and prognostic
implications of microRNAs in human hepatocellular carcinoma. Int J
Cancer. 123:1616–1622. 2008. View Article : Google Scholar : PubMed/NCBI
|
25
|
Su H, Yang JR, Xu T, Huang J, Xu L, Yuan Y
and Zhuang SM: MicroRNA-101, down-regulated in hepatocellular
carcinoma, promotes apoptosis and suppresses tumorigenicity. Cancer
Res. 69:1135–1142. 2009. View Article : Google Scholar : PubMed/NCBI
|
26
|
Diaz G, Melis M, Tice A, Kleiner DE,
Mishra L, Zamboni F and Farci P: Identification of microRNAs
specifically expressed in hepatitis C virus-associated
hepatocellular carcinoma. Int J Cancer. 133:816–824. 2013.
View Article : Google Scholar : PubMed/NCBI
|
27
|
Martinez-Quetglas I, Pinyol R, Dauch D,
Torrecilla S, Tovar V, Moeini A, Alsinet C, Portela A,
Rodriguez-Carunchio L, Solé M, et al: IGF2 Is Up-regulated by
epigenetic mechanisms in hepatocellular carcinomas and is an
actionable oncogene product in experimental models.
Gastroenterology. 151:1192–1205. 2016. View Article : Google Scholar : PubMed/NCBI
|
28
|
Abdalla MA and Haj-Ahmad Y: Promising
candidate urinary MicroRNA biomarkers for the early detection of
hepatocellular carcinoma among high-risk Hepatitis C virus Egyptian
patients. J Cancer. 3:19–31. 2012. View Article : Google Scholar : PubMed/NCBI
|
29
|
Tan Y, Ge G, Pan T, Wen D, Chen L, Yu X,
Zhou X and Gan J: A serum microRNA panel as potential biomarkers
for hepatocellular carcinoma related with hepatitis B virus. PLoS
One. 9:e1079862014. View Article : Google Scholar : PubMed/NCBI
|
30
|
Bevan P: Insulin signalling. J Cell Sci.
114:1429–1430. 2001.PubMed/NCBI
|
31
|
Aleem E, Nehrbass D, Klimek F, Mayer D and
Bannasch P: Upregulation of the insulin receptor and type I
insulin-like growth factor receptor are early events in
hepatocarcinogenesis. Toxicol Pathol. 39:524–543. 2011. View Article : Google Scholar : PubMed/NCBI
|
32
|
Nehrbass D, Klimek F and Bannasch P:
Overexpression of insulin receptor substrate-1 emerges early in
hepatocarcinogenesis and elicits preneoplastic hepatic
glycogenosis. Am J Pathol. 152:341–345. 1998.PubMed/NCBI
|
33
|
Mohr L, Banerjee K, Kleinschmidt M,
Bartolomé Rodriguez MM and Wands JR: Transgenic overexpression of
insulin receptor substrate 1 in hepatocytes enhances hepatocellular
proliferation in young mice only. Hepatol Res. 38:1233–1240.
2008.PubMed/NCBI
|
34
|
Tanaka S and Wands JR: Insulin receptor
substrate 1 overexpression in human hepatocellular carcinoma cells
prevents transforming growth factor beta1-induced apoptosis. Cancer
Res. 56:3391–3394. 1996.PubMed/NCBI
|
35
|
Liang M, Liu J, Ji H, Chen M, Zhao Y, Li
S, Zhang X and Li J: A Aconitum coreanum polysaccharide fraction
induces apoptosis of hepatocellular carcinoma (HCC) cells via
pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of
the P13K/Akt and activation of p38 MAPK signaling pathway and
displays antitumor activity in vivo. Tumour Biol. 36:7085–7091.
2015. View Article : Google Scholar : PubMed/NCBI
|
36
|
Gedaly R, Angulo P, Hundley J, Daily MF,
Chen C and Evers BM: PKI-587 and sorafenib targeting PI3K/AKT/mTOR
and Ras/Raf/MAPK pathways synergistically inhibit HCC cell
proliferation. J Surg Res. 176:542–548. 2012. View Article : Google Scholar : PubMed/NCBI
|
37
|
Wu R, Duan L, Cui F, Cao J, Xiang Y, Tang
Y and Zhou L: S100A9 promotes human hepatocellular carcinoma cell
growth and invasion through RAGE-mediated ERK1/2 and p38 MAPK
pathways. Exp Cell Res. 334:228–238. 2015. View Article : Google Scholar : PubMed/NCBI
|
38
|
Fang X, Yang D, Luo H, Wu S, Dong W, Xiao
J, Yuan S, Ni A, Zhang KJ, Liu XY and Chu L: SNORD126 promotes HCC
and CRC cell growth by activating the PI3K-AKT pathway through
FGFR2. J Mol Cell Biol. 9:243–255. 2017.PubMed/NCBI
|
39
|
Bao H, Liu P, Jiang K, Zhang X, Xie L,
Wang Z and Gong P: Huaier polysaccharide induces apoptosis in
hepatocellular carcinoma cells through p38 MAPK. Oncol Lett.
12:1058–1066. 2016. View Article : Google Scholar : PubMed/NCBI
|
40
|
Jiang S, Wang Q, Feng M, Li J, Guan Z, An
D, Dong M, Peng Y, Kuerban K and Ye L: C2-ceramide enhances
sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and
Erk signaling pathways in HCC cells. Appl Microbiol Biotechnol.
101:1535–1546. 2017. View Article : Google Scholar : PubMed/NCBI
|
41
|
Zhu B, Shi S, Ma YG, Fan F and Yao ZZ:
Lysophosphatidic acid enhances human hepatocellular carcinoma cell
migration, invasion and adhesion through P38 MAPK pathway.
Hepatogastroenterology. 59:785–789. 2012.PubMed/NCBI
|
42
|
Hsieh YH, Hsieh SC, Lee CH, Yang SF, Cheng
CW, Tang MJ, Lin CL, Lin CL and Chou RH: Targeting EMP3 suppresses
proliferation and invasion of hepatocellular carcinoma cells
through inactivation of PI3K/Akt pathway. Oncotarget.
6:34859–34874. 2015. View Article : Google Scholar : PubMed/NCBI
|
43
|
Zheng Y, Wang X, Wang H, Yan W, Zhang Q
and Chang X: Bone morphogenetic protein 2 inhibits hepatocellular
carcinoma growth and migration through downregulation of the
PI3K/AKT pathway. Tumour Biol. 35:5189–5198. 2014. View Article : Google Scholar : PubMed/NCBI
|
44
|
Qiu FN, Huang Y, Chen DY, Li F, Wu YA, Wu
WB and Huang XL: Eukaryotic elongation factor-1α 2 knockdown
inhibits hepatocarcinogenesis by suppressing PI3K/Akt/NF-κB
signaling. World J Gastroenterol. 22:4226–4237. 2016. View Article : Google Scholar : PubMed/NCBI
|
45
|
Zhao J, Dong QZ, Zhong F, Cai LL, Qin ZY,
Liu Y, Lin CZ, Qin LX and He FC: NMI promotes hepatocellular
carcinoma progression via BDKRB2 and MAPK/ERK pathway. Oncotarget.
8:12174–12185. 2017.PubMed/NCBI
|
46
|
Li J, Chen Y, Guo X, Zhou L, Jia Z, Tang
Y, Lin L, Liu W and Ren C: Inhibition of miR-15b decreases cell
migration and metastasis in colorectal cancer. Tumour Biol.
37:8765–8773. 2016. View Article : Google Scholar : PubMed/NCBI
|
47
|
Wang L, Chen YJ, Xu K, Xu H, Shen XZ and
Tu RQ: Circulating microRNAs as a fingerprint for endometrial
endometrioid adenocarcinoma. PLoS One. 9:e1107672014. View Article : Google Scholar : PubMed/NCBI
|
48
|
Fan L, Qi H, Teng J, Su B, Chen H, Wang C
and Xia Q: Identification of serum miRNAs by nano-quantum dots
microarray as diagnostic biomarkers for early detection of
non-small cell lung cancer. Tumour Biol. 37:7777–7784. 2016.
View Article : Google Scholar : PubMed/NCBI
|