Clinical features and prognosis of breast cancer with gastric metastasis

Hong,Joohyun; Kim,Youjin; Cho,Jangho; Lim,Sung  Won; Park,Song  Ee; Kim,Hee  Kyung; Lee,Hansang; Cho,Soo  Youn; Kim,Ji‑Yeon; Ahn,Jin  Seok; Im,Young‑Hyuck; Park,Yeon  Hee

doi:10.3892/ol.2018.9754

Clinical features and prognosis of breast cancer with gastric metastasis

Authors:
- Joohyun Hong
- Youjin Kim
- Jangho Cho
- Sung Won Lim
- Song Ee Park
- Hee Kyung Kim
- Hansang Lee
- Soo Youn Cho
- Ji‑Yeon Kim
- Jin Seok Ahn
- Young‑Hyuck Im
- Yeon Hee Park
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Affiliations: Division of Hematology‑Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea, Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
Published online on: November 23, 2018 https://doi.org/10.3892/ol.2018.9754
Pages: 1833-1841

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Abstract

Breast cancer rarely metastasizes to the gastrointestinal tract, including the stomach. Due to the rarity of this metastasis, it is occasionally confused with a primary stomach malignancy. However, discriminating characteristic features with clinical implications may exist. The aim of the current study was to analyze the clinical features and prognosis of breast cancer with gastric metastasis. Between January 1994 and October 2016, 13 patients at Samsung Medical Center (Seoul, Korea) were clinically or pathologically determined to have breast cancer with gastric metastasis. The present study retrospectively collected clinicopathological data from the electronic medical records of these 13 female patients. At breast cancer diagnosis, the median patient age was 45 years. A total of 7 patients (53.8%) presented with invasive lobular carcinoma (ILC) and 6 (46.2%) with invasive ductal carcinoma. Of the 13 patients, 11 were stage I‑III at initial breast cancer diagnosis and underwent surgery. Positivity of breast cancer tissue samples for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) was 92.3, 76.9 and 0%, respectively. Positivity of gastric metastasis lesions, based on immunohistochemistry results, was 81.8, 50 and 0% for ER, PR and HER2, respectively. The stomach was the location of the first metastatic lesion in 6 out of the 11 patients (54.5%) with de novo stage I‑III cancer. The median time interval from initial breast cancer diagnosis to stomach metastasis was 77.5 months. The 3‑year survival rate was 79.1%, and the estimated mean survival time was 35.1 months. Breast cancer with gastric metastasis is rare, and due to this fact, a thorough pathological review and greater clinical suspicion are required in these cases.

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1	Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI
2	Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. N Engl J Med. 363:1938–1948. 2010. View Article : Google Scholar : PubMed/NCBI
3	Harris M, Howell A, Chrissohou M, Swindell RI, Hudson M and Sellwood RA: A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer. 50:231984. View Article : Google Scholar : PubMed/NCBI
4	Kennecke H, Yerushalmi R, Woods R, Cheang MCU, Voduc D, Speers CH, Nielsen TO and Gelmon K: Metastatic behavior of breast cancer subtypes. J Clin Oncol. 28:3271–3277. 2010. View Article : Google Scholar : PubMed/NCBI
5	Patanaphan V, Salazar OM and Risco R: Breast cancer: Metastatic patterns and their prognosis. South Med J. 81:1109–1112. 1988. View Article : Google Scholar : PubMed/NCBI
6	Abe T, Yoshidome K, Iijima H, Oyama T, Akamatsu H, Kawai N, Yasumaru M, Tsujimoto M, Nishida T and Tsujii M: Metastatic breast cancer mimicking primary depressed gastric cancer. Gastroint Endosc. 70:1241–1242. 2009. View Article : Google Scholar
7	Arrangoiz R, Papavasiliou P, Dushkin H and Farma JM: Case report and literature review: Metastatic lobular carcinoma of the breast an unusual presentation. Int J Case Rep. 2:301–305. 2011. View Article : Google Scholar
8	Aurello P, D'Angelo F, Cosenza G, Petrocca S, Stoppacciaro A, Ramacciato G and Ziparo V: Gastric metastasis 14 years after mastectomy for breast lobular carcinoma: Case Report and Literature Review. Am Surg. 72:456–460. 2006.PubMed/NCBI
9	Brandi G, Campadelli E, Nobili E and Leone O: Breast carcinoma presenting as linitis plastica. Dig Liver Dis. 42:3062010. View Article : Google Scholar : PubMed/NCBI
10	Dumoulin FL and Gupta RS: Breast cancer metastasis to the stomach resembling small benign gastric polyps. Gastrointest Endosc. 69:174–175. 2009. View Article : Google Scholar : PubMed/NCBI
11	Ellis MC, Mason T, Barnett J, Kiesow LL and Vetto JT: Gastric malignancies in breast cancer survivors: Pathology and outcomes. Am J Surg. 197:633–636. 2009. View Article : Google Scholar : PubMed/NCBI
12	Kudo T, Matsumoto T, Nakamura S, Nakamura S, Esaki M, Yada S, Hirahashi M, Yao T and Iida M: Solitary minute metastasis from breast cancer mimicking primary intramucosal gastric signet-cell cancer. Gastrointest Endosc. 62:139–140. 2005. View Article : Google Scholar : PubMed/NCBI
13	Pectasides D, Psyrri A, Pliarchopoulou K, Floros T, Papaxoinis G, Skondra M, Papatsibas G, Macheras A, Athanasas G, Arapantoni-Datioti P and Economopoulos T: Gastric metastases originating from breast cancer: Report of 8 cases and review of the literature. Anticancer Res. 29:4759–4763. 2009.PubMed/NCBI
14	Rusticeanu M, Schuster M, Moga SL, Solomayer E-F, Bohle RM, Lammert F and Zimmer V: Metastatic lobular breast cancer presenting as gastric linitis plastica. Am J Med. 124:e5–e6. 2011. View Article : Google Scholar : PubMed/NCBI
15	Schwarz RE, Klimstra DS and Turnbull ADM: Metastatic breast cancer masquerading as gastrointestinal primary. Am J Gastroenterol. 93:111–114. 1998. View Article : Google Scholar : PubMed/NCBI
16	Whitty LA, Crawford DL, Woodland JH, Patel JC, Nattier B and Thomas CR: Metastatic breast cancer presenting as linitis plastica of the stomach. Gastric Cancer. 8:193–197. 2005. View Article : Google Scholar : PubMed/NCBI
17	Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature. 410:50–60. 2001. View Article : Google Scholar : PubMed/NCBI
18	Edge SB and Compton CC: The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI
19	Laurén P: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand. 64:31–49. 1965. View Article : Google Scholar : PubMed/NCBI
20	Hicks DG and Schiffhauer L: Standardized assessment of the HER2 status in breast cancer by immunohistochemistry. Lab Med. 42:459–467. 2011. View Article : Google Scholar
21	Taal BG, Peterse H and Boot H: Clinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma. Cancer. 89:2214–2221. 2000. View Article : Google Scholar : PubMed/NCBI
22	Xu L, Liang S, Yan N, Zhang L, Gu H, Fei X, Xu Y and Zhang F: Metastatic gastric cancer from breast carcinoma: A report of 78 cases. Oncol Lett. 14:4069–4077. 2017. View Article : Google Scholar : PubMed/NCBI
23	Orditura M, Galizia G, Sforza V, Gambardella V, Fabozzi A, Laterza MM, Andreozzi F, Ventriglia J, Savastano B, Mabilia A, Lieto E, et al: Treatment of gastric cancer. World J Gastroenterol. 20:1635–1649. 2014. View Article : Google Scholar : PubMed/NCBI