Open Access

Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features

  • Authors:
    • Cornelia S.L. Müller
    • Léa Kreie
    • Florian Bochen
    • Thorsten Pfuhl
    • Sigrun Smola
    • Stefan Gräber
    • Thomas Vogt
    • Bernhard Schick
    • Maximilian Linxweiler
  • View Affiliations

  • Published online on: November 27, 2018     https://doi.org/10.3892/ol.2018.9767
  • Pages: 1768-1776
  • Copyright: © Müller et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Atypical fibroxanthoma (AFX) is a rare mesenchymal tumor with predominance in older male patients located mainly in chronically UV‑exposed skin. Differentiation from clinically more aggressive pleomorphic dermal sarcoma (PDS) is still under debate and immunohistochemical markers are not available yet. An immunohistochemical study, including 41 cases of AFX was conducted to investigate the expression of 3q encoded oncogene SEC62 in AFX and determine the associations with histomorphologic, clinical and viral parameters. Our cohort displayed a mean of 79.9 years at the onset of the disease. In total, 90.2% (37/41) AFXs were located in the head and neck area, whereas, four were located at the extremities (9.7%). Tumor diameter ranged between 0.06 and 40 cm² with a mean of 5.7 cm². SEC62 expression was markedly increased in lesional tissue compared with the adjacent healthy squamous epithelium. We found significantly higher expression of SEC62 in cases of AFX with tumor necrosis. Tendency of higher Sec62‑IRS‑scores were found for tumors with higher Clark levels and a tumor size >5 cm². Sec62 is involved in endoplasmic reticulum stress tolerance and cell migration, and has been identified as a novel prognostic marker for non‑small cell lung cancer as well as head and neck squamous cell carcinoma. For the first time, to the best of our knowledge, we suggest a role of 3q oncogene SEC62 in AFX and discuss a potential prognostic relevance in cases of disputable AFX with unfavorable histomorphologic features and may initiate a discussion on Sec62 serving as discriminating marker between AFX and PDS.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
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Spandidos Publications style
Müller CS, Kreie L, Bochen F, Pfuhl T, Smola S, Gräber S, Vogt T, Schick B and Linxweiler M: Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features. Oncol Lett 17: 1768-1776, 2019
APA
Müller, C.S., Kreie, L., Bochen, F., Pfuhl, T., Smola, S., Gräber, S. ... Linxweiler, M. (2019). Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features. Oncology Letters, 17, 1768-1776. https://doi.org/10.3892/ol.2018.9767
MLA
Müller, C. S., Kreie, L., Bochen, F., Pfuhl, T., Smola, S., Gräber, S., Vogt, T., Schick, B., Linxweiler, M."Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features". Oncology Letters 17.2 (2019): 1768-1776.
Chicago
Müller, C. S., Kreie, L., Bochen, F., Pfuhl, T., Smola, S., Gräber, S., Vogt, T., Schick, B., Linxweiler, M."Expression of 3q oncogene SEC62 in atypical fibroxanthoma‑immunohistochemical analysis of 41 cases and correlation with clinical, viral and histopathologic features". Oncology Letters 17, no. 2 (2019): 1768-1776. https://doi.org/10.3892/ol.2018.9767