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Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells

  • Authors:
    • Wen‑Xue Chen
    • Jin‑Gao Li
    • Xiang‑Hui Wan
    • Xue‑Sen Zou
    • Shu‑Yi Qi
    • Yu‑Qing Zhang
    • Qiu‑Min Weng
    • Jun‑Yu Li
    • Wen‑Min Xiong
    • Chen Xie
    • Wei‑Liang Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China, Department of Radiotherapy, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China, Jiangxi Railway Health Supervision Institute, Nanchang, Jiangxi 330003, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1581-1588
    |
    Published online on: November 28, 2018
       https://doi.org/10.3892/ol.2018.9771
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Abstract

The aim of the present study was to discuss the design of a microfluidic chip consisting of columns, and its use for the enrichment of nasopharyngeal cancer (NPC) cells. A microfluidic chip experiment was simulated using FLUENT software. Within the microfluidic chip, aptamers were bound to the reaction chamber (consisting of columns) using a biotin‑avidin system. Cell suspension was introduced into the reaction chamber to capture NPC cells. NPC cells were subsequently eluted, and the capture rate of the cells was calculated. The modified aptamer‑bound microfluidic chip was able to capture NPC cells with a capture rate of ~90%. The modified aptamer‑bound microfluidic chip has a wide range of potential applications for the diagnosis of NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen WX, Li JG, Wan XH, Zou XS, Qi SY, Zhang YQ, Weng QM, Li JY, Xiong WM, Xie C, Xie C, et al: Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells. Oncol Lett 17: 1581-1588, 2019.
APA
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y. ... Cheng, W. (2019). Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells. Oncology Letters, 17, 1581-1588. https://doi.org/10.3892/ol.2018.9771
MLA
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y., Weng, Q., Li, J., Xiong, W., Xie, C., Cheng, W."Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells". Oncology Letters 17.2 (2019): 1581-1588.
Chicago
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y., Weng, Q., Li, J., Xiong, W., Xie, C., Cheng, W."Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells". Oncology Letters 17, no. 2 (2019): 1581-1588. https://doi.org/10.3892/ol.2018.9771
Copy and paste a formatted citation
x
Spandidos Publications style
Chen WX, Li JG, Wan XH, Zou XS, Qi SY, Zhang YQ, Weng QM, Li JY, Xiong WM, Xie C, Xie C, et al: Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells. Oncol Lett 17: 1581-1588, 2019.
APA
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y. ... Cheng, W. (2019). Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells. Oncology Letters, 17, 1581-1588. https://doi.org/10.3892/ol.2018.9771
MLA
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y., Weng, Q., Li, J., Xiong, W., Xie, C., Cheng, W."Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells". Oncology Letters 17.2 (2019): 1581-1588.
Chicago
Chen, W., Li, J., Wan, X., Zou, X., Qi, S., Zhang, Y., Weng, Q., Li, J., Xiong, W., Xie, C., Cheng, W."Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells". Oncology Letters 17, no. 2 (2019): 1581-1588. https://doi.org/10.3892/ol.2018.9771
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