Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2019 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2019 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Use of clinical nomograms for predicting survival outcomes in young women with breast cancer

  • Authors:
    • Hui Lin
    • Fan Zhang
    • Luanhong Wang
    • De Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Breast Medical Oncology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China, Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China, Department of Gynecology, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 1505-1516
    |
    Published online on: November 28, 2018
       https://doi.org/10.3892/ol.2018.9772
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Early‑onset breast cancer (BC) has been recognized to be more aggressive compared with its later counterparts. Survival models of BC in young patients have rarely been reported in previous studies. The current study aimed to establish and validate prediction models with clinicopathological variables for visceral metastasis‑free survival (VFS), disease‑free‑survival (DFS) and overall survival (OS) time in young patients with BC. Clinicopathological data were obtained for 351 patients with primary breast tumors who were ≤40 years old. Univariate and multivariate analyses were performed and nomograms were established to screen and illustrate the prognostic factors. Risk scores were calculated based on coefficients from the Cox regression analysis. Internal validation of the prediction models was conducted by predicting the prognosis of cases randomly sampled from the cohort used in the current study. Multivariate analysis demonstrated that N stage (P=0.004), molecular subtype (P=0.007) and age (P=0.005) were significant independent prognostic factors for VFS. Similarly, N stage (P=0.002) and molecular subtype (P=0.001) were significantly associated with DFS. In addition, N stage (P=0.006), molecular subtype (P=0.006) and the presence of an initially inoperable tumor (P=0.005) were significant independent prognostic factors for OS. According to the Cox regression analysis, nomograms were generated to illustrate the effect of independent prognostic factors on VFS, DFS and OS. Risk scores were calculated and internal validation demonstrated the reliability of the prediction models. In conclusion, N stage and molecular subtype were identified as predictors for VFS, DFS and OS in early‑onset BC. Furthermore, an age of <35 years at diagnosis was revealed to be unfavorable for VFS and the presence of an initially inoperable tumor was identified to reduce OS time.
View Figures

Figure 1

Figure 2

View References

1 

DeSantis CE, Bray F, Ferlay J, Lortet-Tieulent J, Anderson BO and Jemal A: International variation in female breast cancer incidence and mortality rates. Cancer Epidemiol Biomarkers Prev. 24:1495–1506. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Fan L, Strasser-Weippl K, Li JJ, St Louis J, Finkelstein DM, Yu KD, Chen WQ, Shao ZM and Goss PE: Breast cancer in China. Lancet Oncol. 15:E279–E289. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Tang LC, Yin WJ, Di GH, Shen ZZ and Shao ZM: Unfavourable clinicopathologic features and low response rate to systemic adjuvant therapy: Results with regard to poor survival in young Chinese breast cancer patients. Breast Cancer Res Treat. 122:95–104. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Zabicki K, Colbert JA, Dominguez FJ, Gadd MA, Hughes KS, Jones JL, Specht MC, Michaelson JS and Smith BL: Breast cancer diagnosis in women <or=40 versus 50 to 60 years: Increasing size and stage disparity compared with older women over time. Ann Surg Oncol. 13:1072–1077. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Goksu SS, Tastekin D, Arslan D, Gunduz S, Tatli AM, Unal D, Salim D, Guler T and Coskun HS: Clinicopathologic features and molecular subtypes of breast cancer in young women (age </=35). Asian Pac J Cancer prev. 15:6665–6668. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Tjokrowidjaja A, Lee CK, Houssami N and Lord S: Metastatic breast cancer in young women: A population-based cohort study to describe risk and prognosis. Intern Med J. 44:764–770. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Keegan TH, DeRouen MC, Press DJ, Kurian AW and Clarke CA: Occurrence of breast cancer subtypes in adolescent and young adult women. Breast Cancer Res. 14:R552012. View Article : Google Scholar : PubMed/NCBI

8 

Chen HL, Ding A and Wang FW: Prognostic effect analysis of molecular subtype on young breast cancer patients. Chin J Cancer Res. 27:428–436. 2015.PubMed/NCBI

9 

Liedtke C, Rody A, Gluz O, Baumann K, Beyer D, Kohls EB, Lausen K, Hanker L, Holtrich U, Becker S and Karn T: The prognostic impact of age in different molecular subtypes of breast cancer. Breast Cancer Res Treat. 152:667–673. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Azim HA Jr, Nguyen B, Brohee S, Zoppoli G and Sotiriou C: Genomic aberrations in young and elderly breast cancer patients. BMC Med. 13:2662015. View Article : Google Scholar : PubMed/NCBI

11 

Goldhirsch A, Wood WC, Gelber RD, Coates AS, Thürlimann B and Senn HJ; 10th St, : Gallen conference: Progress and promise: Highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Ann Oncol. 18:1133–1144. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Plichta JK, Rai U, Tang R, Coopey SB, Buckley JM, Gadd MA, Specht MC, Hughes KS, Taghian AG and Smith BL: Factors associated with recurrence rates and long-term survival in women diagnosed with breast cancer ages 40 and younger. Ann Surg Oncol. 23:3212–3220. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Fredholm H, Eaker S, Frisell J, Holmberg L, Fredriksson I and Lindman H: Breast cancer in young women: Poor survival despite intensive treatment. PLoS One. 4:e76952009. View Article : Google Scholar : PubMed/NCBI

14 

Hearne BJ, Teare MD, Butt M and Donaldson L: Comparison of nottingham prognostic index and adjuvant online prognostic tools in young women with breast cancer: Review of a single-institution experience. BMJ open. 5:e0055762015. View Article : Google Scholar : PubMed/NCBI

15 

Karihtala P, Winqvist R, Bloigu R and Jukkola-Vuorinen A: Long-term observational follow-up study of breast cancer diagnosed in women </=40 years old. Breast. 19:456–461. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Edge SB and Compton CC: The American joint committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Alco G, Bozdogan A, Selamoglu D, Pilanci KN, Tuzlali S, Ordu C, Igdem S, Okkan S, Dincer M, Demir G and Ozmen V: Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients. Oncol Lett. 9:1046–1054. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Wang S, Saboorian MH, Frenkel E, Hynan L, Gokaslan ST and Ashfaq R: Laboratory assessment of the status of Her-2/neu protein and oncogene in breast cancer specimens: Comparison of immunohistochemistry assay with fluorescence in situ hybridisation assays. J Clin Pathol. 53:374–381. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Shukla S, Pia Patric IR, Thinagararjan S, Srinivasan S, Mondal B, Hegde AS, Chandramouli BA, Santosh V, Arivazhagan A and Somasundaram K: A DNA methylation prognostic signature of glioblastoma: Identification of NPTX2-PTEN-NF-kappaB nexus. Cancer Res. 73:6563–6573. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Tang LC, Jin X, Yang HY, He M, Chang H, Shao ZM and Di GH: Luminal B subtype: A key factor for the worse prognosis of young breast cancer patients in China. BMC Cancer. 15:2012015. View Article : Google Scholar : PubMed/NCBI

21 

Lee CK, Hudson M, Stockler M, Coates AS, Ackland S, Gebski V, Lord S, Friedlander M, Boyle F and Simes RJ: A nomogram to predict survival time in women starting first-line chemotherapy for advanced breast cancer. Breast cancer Res Treat. 129:467–476. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Vernerey D, Huguet F, Vienot A, Goldstein D, Paget-Bailly S, Van Laethem JL, Glimelius B, Artru P, Moore MJ, André T, et al: Prognostic nomogram and score to predict overall survival in locally advanced untreated pancreatic cancer (PROLAP). Br J Cancer. 115:281–289. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Liang W, Zhang L, Jiang G, Wang Q, Liu L, Liu D, Wang Z, Zhu Z, Deng Q, Xiong X, et al: Development and validation of a nomogram for predicting survival in patients with resected non-small-cell lung cancer. J Clin Oncol. 33:861–869. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Keam B, Im SA, Park S, Nam BH, Han SW, Oh DY, Kim JH, Lee SH, Han W, Kim DW, et al: Nomogram predicting clinical outcomes in breast cancer patients treated with neoadjuvant chemotherapy. J Cancer Res Clin Oncol. 137:1301–1308. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Qiu SQ, Zeng HC, Zhang F, Chen C, Huang WH, Pleijhuis RG, Wu JD, van Dam GM and Zhang GJ: A nomogram to predict the probability of axillary lymph node metastasis in early breast cancer patients with positive axillary ultrasound. Sci Rep. 6:211962016. View Article : Google Scholar : PubMed/NCBI

26 

Witteveen A, Vliegen IM, Sonke GS, Klaase JM, MJ IJ and Siesling S: Personalisation of breast cancer follow-up: A time-dependent prognostic nomogram for the estimation of annual risk of locoregional recurrence in early breast cancer patients. Breast Cancer Res Treat. 152:627–636. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Song N, Choi JY, Sung H, Jeon S, Chung S, Park SK, Han W, Lee JW, Kim MK, Lee JY, et al: Prediction of breast cancer survival using clinical and genetic markers by tumor subtypes. PLoS One. 10:e01224132015. View Article : Google Scholar : PubMed/NCBI

28 

Hennigs A, Riedel F, Gondos A, Sinn P, Schirmacher P, Marmé F, Jäger D, Kauczor HU, Stieber A, Lindel K, et al: Prognosis of breast cancer molecular subtypes in routine clinical care: A large prospective cohort study. BMC Cancer. 16:7342016. View Article : Google Scholar : PubMed/NCBI

29 

Savci-Heijink CD, Halfwerk H, Hooijer GK, Horlings HM, Wesseling J and van de Vijver MJ: Retrospective analysis of metastatic behaviour of breast cancer subtypes. Breast Cancer Res Treat. 150:547–557. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Zhao Y, Dong X, Li R, Song J and Zhang D: Correlation between clinical-pathologic factors and long-term follow-up in young breast cancer patients. Transl Oncol. 8:265–272. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Kast K, Link T, Friedrich K, Petzold A, Niedostatek A, Schoffer O, Werner C, Klug SJ, Werner A, Gatzweiler A, et al: Impact of breast cancer subtypes and patterns of metastasis on outcome. Breast Cancer Res Treat. 150:621–629. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Bartmann C, Diessner J, Blettner M, Häusler S, Janni W, Kreienberg R, Krockenberger M, Schwentner L, Stein R, Stüber T, et al: Factors influencing the development of visceral metastasis of breast cancer: A retrospective multi-center study. Breast. 31:66–75. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lin H, Zhang F, Wang L and Zeng D: Use of clinical nomograms for predicting survival outcomes in young women with breast cancer. Oncol Lett 17: 1505-1516, 2019.
APA
Lin, H., Zhang, F., Wang, L., & Zeng, D. (2019). Use of clinical nomograms for predicting survival outcomes in young women with breast cancer. Oncology Letters, 17, 1505-1516. https://doi.org/10.3892/ol.2018.9772
MLA
Lin, H., Zhang, F., Wang, L., Zeng, D."Use of clinical nomograms for predicting survival outcomes in young women with breast cancer". Oncology Letters 17.2 (2019): 1505-1516.
Chicago
Lin, H., Zhang, F., Wang, L., Zeng, D."Use of clinical nomograms for predicting survival outcomes in young women with breast cancer". Oncology Letters 17, no. 2 (2019): 1505-1516. https://doi.org/10.3892/ol.2018.9772
Copy and paste a formatted citation
x
Spandidos Publications style
Lin H, Zhang F, Wang L and Zeng D: Use of clinical nomograms for predicting survival outcomes in young women with breast cancer. Oncol Lett 17: 1505-1516, 2019.
APA
Lin, H., Zhang, F., Wang, L., & Zeng, D. (2019). Use of clinical nomograms for predicting survival outcomes in young women with breast cancer. Oncology Letters, 17, 1505-1516. https://doi.org/10.3892/ol.2018.9772
MLA
Lin, H., Zhang, F., Wang, L., Zeng, D."Use of clinical nomograms for predicting survival outcomes in young women with breast cancer". Oncology Letters 17.2 (2019): 1505-1516.
Chicago
Lin, H., Zhang, F., Wang, L., Zeng, D."Use of clinical nomograms for predicting survival outcomes in young women with breast cancer". Oncology Letters 17, no. 2 (2019): 1505-1516. https://doi.org/10.3892/ol.2018.9772
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team