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Article Open Access

Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage

  • Authors:
    • Yifeng He
    • Yu Zhou
    • Ji Zhang
    • Fei Yuan
    • Jun Wang
    • Lianjun Du
    • Qi Zhou
    • Jing Liang
    • Xiaoyi Ding
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, Shanghai Institute of Traumatology and Orthopedics, Shanghai Key Laboratory for The Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Pages: 1425-1434
    |
    Published online on: November 30, 2018
       https://doi.org/10.3892/ol.2018.9778
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Abstract

Giant cell tumor of bone (GCTB) is among the most prevalent types of tumor of the bone in East and Southeast Asia. The high rate of local recurrence following intralesional curettage poses a challenge for the clinical treatment of GCTB. In the present study, the expression of matrix metalloproteinase‑9 (MMP‑9), vascular endothelial growth factor (VEGF), receptor activator of nuclear factor‑κB (RANK) and RANK ligand (RANKL) in GCTB was investigated by immunohistochemical staining. A correlation between expression and preoperative magnetic resonance imaging (MRI) features was identified. The patients were followed up for ≥2 years after intralesional curettage. The rates of local recurrence were compared among different groups. A total of 74 cases of GCTB in the proximal tibia or distal femur were investigated. MRI features were retrospectively examined by correlation analysis. The expression of MMP‑9 was demonstrated to be associated with cystic changes and the ‘paint brush borders’ sign (P<0.05), and positively associated with the expression of RANKL (P<0.05) and VEGF (P<0.05). Cystic changes, the ‘paint brush borders’ sign and adjacent soft tissue invasion were associated with high rates of local recurrence (P<0.05) and were therefore identified as significant risk factors. Pathologically, the ‘paint brush borders’ sign was demonstrated to be indicative of local invasion of the bone. These findings may be useful for predicting local recurrence of GCTB, and may provide important insight into the preoperative MRI features and molecular expression patterns of GCTB tumors.
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Copy and paste a formatted citation
Spandidos Publications style
He Y, Zhou Y, Zhang J, Yuan F, Wang J, Du L, Zhou Q, Liang J and Ding X: Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage. Oncol Lett 17: 1425-1434, 2019.
APA
He, Y., Zhou, Y., Zhang, J., Yuan, F., Wang, J., Du, L. ... Ding, X. (2019). Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage. Oncology Letters, 17, 1425-1434. https://doi.org/10.3892/ol.2018.9778
MLA
He, Y., Zhou, Y., Zhang, J., Yuan, F., Wang, J., Du, L., Zhou, Q., Liang, J., Ding, X."Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage". Oncology Letters 17.2 (2019): 1425-1434.
Chicago
He, Y., Zhou, Y., Zhang, J., Yuan, F., Wang, J., Du, L., Zhou, Q., Liang, J., Ding, X."Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage". Oncology Letters 17, no. 2 (2019): 1425-1434. https://doi.org/10.3892/ol.2018.9778
Copy and paste a formatted citation
x
Spandidos Publications style
He Y, Zhou Y, Zhang J, Yuan F, Wang J, Du L, Zhou Q, Liang J and Ding X: Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage. Oncol Lett 17: 1425-1434, 2019.
APA
He, Y., Zhou, Y., Zhang, J., Yuan, F., Wang, J., Du, L. ... Ding, X. (2019). Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage. Oncology Letters, 17, 1425-1434. https://doi.org/10.3892/ol.2018.9778
MLA
He, Y., Zhou, Y., Zhang, J., Yuan, F., Wang, J., Du, L., Zhou, Q., Liang, J., Ding, X."Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage". Oncology Letters 17.2 (2019): 1425-1434.
Chicago
He, Y., Zhou, Y., Zhang, J., Yuan, F., Wang, J., Du, L., Zhou, Q., Liang, J., Ding, X."Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage". Oncology Letters 17, no. 2 (2019): 1425-1434. https://doi.org/10.3892/ol.2018.9778
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