Open Access

Circulating tumor DNA detection: A potential tool for colorectal cancer management (Review)

  • Authors:
    • Huizi Li
    • Changwen Jing
    • Jianzhong Wu
    • Jie Ni
    • Huanhuan Sha
    • Xiaoyue Xu
    • Yuanyuan Du
    • Rui Lou
    • Shuchen Dong
    • Jifeng Feng
  • View Affiliations

  • Published online on: December 5, 2018     https://doi.org/10.3892/ol.2018.9794
  • Pages: 1409-1416
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is frequently diagnosed at an advanced stage of the disease, the pathogenesis of which is influenced by genetic and epigenetic events. Circulating tumor DNA (ctDNA) is extracellular DNA that is present in a number of bodily fluids, including blood, synovial fluid and cerebrospinal fluid. Compared with performing a tissue biopsy, ctDNA examination presents the advantages of minimal invasion and greater convenience. ctDNA is commonly used to identify actionable genomic alterations, monitor treatment responses, unravel therapeutic resistance and potentially detect disease progression prior to clinical and radiological confirmation. The technique can potentially serve as a non‑invasive diagnostic tool in personalized medicine, as it demonstrates prognostic value in the management of patients with CRC. ctDNA detection continues to demonstrate inherent advantages compared with other methods, thus serving an increasingly important role in tumor monitoring and oncotherapy. The aim of the current review was to explore the clinical applications of ctDNA in patients with CRC, including early detection and screening, medication guidance, resistance prediction, and residual lesion and recurrence monitoring. Furthermore, several technical methods for ctDNA detection and analysis are explored, as well as other potential biomarkers.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li H, Jing C, Wu J, Ni J, Sha H, Xu X, Du Y, Lou R, Dong S, Feng J, Feng J, et al: Circulating tumor DNA detection: A potential tool for colorectal cancer management (Review). Oncol Lett 17: 1409-1416, 2019
APA
Li, H., Jing, C., Wu, J., Ni, J., Sha, H., Xu, X. ... Feng, J. (2019). Circulating tumor DNA detection: A potential tool for colorectal cancer management (Review). Oncology Letters, 17, 1409-1416. https://doi.org/10.3892/ol.2018.9794
MLA
Li, H., Jing, C., Wu, J., Ni, J., Sha, H., Xu, X., Du, Y., Lou, R., Dong, S., Feng, J."Circulating tumor DNA detection: A potential tool for colorectal cancer management (Review)". Oncology Letters 17.2 (2019): 1409-1416.
Chicago
Li, H., Jing, C., Wu, J., Ni, J., Sha, H., Xu, X., Du, Y., Lou, R., Dong, S., Feng, J."Circulating tumor DNA detection: A potential tool for colorectal cancer management (Review)". Oncology Letters 17, no. 2 (2019): 1409-1416. https://doi.org/10.3892/ol.2018.9794