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Correlation analysis of IL‑4, IL‑10 and APN levels with postoperative infection of colorectal cancer

  • Authors:
    • Jianyun He
    • Zhiyan Wang
    • Sihai Zhang

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  • Published online on: December 6, 2018     https://doi.org/10.3892/ol.2018.9798
  • Pages: 1603-1608
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Abstract

Changes in expression levels of serum interleukin‑4 (IL‑4), IL‑10 and adiponectin (APN) in patients with postoperative infection of colorectal cancer were studied. The clinical data of 159 patients receiving radical surgery for colorectal cancer in Xiangyang No. 1 People's Hospital, Hubei University of Medicine from January 2014 to December 2017, were retrospectively analyzed. A total of 67 patients with postoperative infection were enrolled into the infection group, while the remaining 92 patients without infection were enrolled into the non‑infection group. The expression levels of serum IL‑4, IL‑10 and APN of patients were detected via enzyme‑linked immunosorbent assay. The correlation of IL‑4, IL‑10 and APN levels with stage of colorectal cancer were explored by the Spearman's correlation analysis. The expression levels of IL‑4 and IL‑10 in the infection group were significantly higher than those in the non‑infection group at day 3 after surgery (P<0.05). The expression level of APN in the infection group was lower than that in the non‑infection group at day 3 after surgery (P<0.05). The serum IL‑4 and IL‑10 levels in pulmonary infection was higher and the serum IL‑10 level in pulmonary infection was higher than those in incision infection and abdominal infection (P<0.05). The IL‑4 and IL‑10 levels in patients with colorectal cancer in the infection group at day 3 after surgery had a significant positive correlation with the stage of colorectal cancer (r=0.9357, P<0.001; r=0.9717, P<0.001), and the APN level in patients with colorectal cancer in the infection group at day 3 after surgery had a significant negative correlation with the stage of colorectal cancer (r=‑0.9736, P<0.001). The serum IL‑4 and IL‑10 levels in patients with postoperative infection of colorectal cancer are positively correlated with the stage of cancer, while the serum APN level was negatively correlated with the stage of cancer.
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February-2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
He J, Wang Z and Zhang S: Correlation analysis of IL‑4, IL‑10 and APN levels with postoperative infection of colorectal cancer. Oncol Lett 17: 1603-1608, 2019
APA
He, J., Wang, Z., & Zhang, S. (2019). Correlation analysis of IL‑4, IL‑10 and APN levels with postoperative infection of colorectal cancer. Oncology Letters, 17, 1603-1608. https://doi.org/10.3892/ol.2018.9798
MLA
He, J., Wang, Z., Zhang, S."Correlation analysis of IL‑4, IL‑10 and APN levels with postoperative infection of colorectal cancer". Oncology Letters 17.2 (2019): 1603-1608.
Chicago
He, J., Wang, Z., Zhang, S."Correlation analysis of IL‑4, IL‑10 and APN levels with postoperative infection of colorectal cancer". Oncology Letters 17, no. 2 (2019): 1603-1608. https://doi.org/10.3892/ol.2018.9798