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Article Open Access

Distribution of cancer stem cells in two human brain gliomas

  • Authors:
    • Lilei Peng
    • Jie Fu
    • Weijun Wang
    • Florence M. Hofman
    • Thomas C. Chen
    • Ligang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Neurology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA, Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Pages: 2123-2130
    |
    Published online on: December 12, 2018
       https://doi.org/10.3892/ol.2018.9824
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Abstract

There is compelling evidence that brain tumors, particularly glioblastoma multiforme (GBM), harbor a small population of cancer stem cells (CSCs). These CSCs have the ability to undergo self‑renewal, initiate tumors in vivo, and are resistant to chemotherapy and radiation therapy. The present study determined the spatial distribution of CSCs within the donated brains of two deceased patients affected by glioblastoma multiforme. The following six grossly visible functional regions were identified: Necrotic tumor, viable solid tumor, infiltrating tumor edge, peritumoral normal brain, normal brain close to the tumor and normal brain distant from the tumor. Each region was snap‑frozen, sectioned and immunostained for the CSC biomarkers prominin‑1 (CD133) and sex‑determining region Y‑box 2 (SOX2). The percentages of CD133+ and SOX2+ cells within each region were determined. Different percentages of CD133+ and SOX2+ cells were identified in different regions. Significantly higher percentages of CD133+ and SOX2+ cells were indicated at the infiltrating tumor edge when compared with other areas. In summary, the spatial distributions of CSCs in these two brains with glioblastoma multiforme were similar, with the highest concentration being at the infiltrating tumor edge. This suggests that the edge of the tumor is the moving front for tumor progression and invasion, and should be targeted for therapeutic intervention.
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Copy and paste a formatted citation
Spandidos Publications style
Peng L, Fu J, Wang W, Hofman FM, Chen TC and Chen L: Distribution of cancer stem cells in two human brain gliomas. Oncol Lett 17: 2123-2130, 2019.
APA
Peng, L., Fu, J., Wang, W., Hofman, F.M., Chen, T.C., & Chen, L. (2019). Distribution of cancer stem cells in two human brain gliomas. Oncology Letters, 17, 2123-2130. https://doi.org/10.3892/ol.2018.9824
MLA
Peng, L., Fu, J., Wang, W., Hofman, F. M., Chen, T. C., Chen, L."Distribution of cancer stem cells in two human brain gliomas". Oncology Letters 17.2 (2019): 2123-2130.
Chicago
Peng, L., Fu, J., Wang, W., Hofman, F. M., Chen, T. C., Chen, L."Distribution of cancer stem cells in two human brain gliomas". Oncology Letters 17, no. 2 (2019): 2123-2130. https://doi.org/10.3892/ol.2018.9824
Copy and paste a formatted citation
x
Spandidos Publications style
Peng L, Fu J, Wang W, Hofman FM, Chen TC and Chen L: Distribution of cancer stem cells in two human brain gliomas. Oncol Lett 17: 2123-2130, 2019.
APA
Peng, L., Fu, J., Wang, W., Hofman, F.M., Chen, T.C., & Chen, L. (2019). Distribution of cancer stem cells in two human brain gliomas. Oncology Letters, 17, 2123-2130. https://doi.org/10.3892/ol.2018.9824
MLA
Peng, L., Fu, J., Wang, W., Hofman, F. M., Chen, T. C., Chen, L."Distribution of cancer stem cells in two human brain gliomas". Oncology Letters 17.2 (2019): 2123-2130.
Chicago
Peng, L., Fu, J., Wang, W., Hofman, F. M., Chen, T. C., Chen, L."Distribution of cancer stem cells in two human brain gliomas". Oncology Letters 17, no. 2 (2019): 2123-2130. https://doi.org/10.3892/ol.2018.9824
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