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Article Open Access

Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer

  • Authors:
    • Wenting Ji
    • Weihua Lou
    • Zubei Hong
    • Lihua Qiu
    • Wen Di
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China
    Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2099-2106
    |
    Published online on: December 12, 2018
       https://doi.org/10.3892/ol.2018.9825
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Abstract

Cervical cancer is one of the most prevalent female cancer types in developing countries. ThinPrep cytological test (TCT) and human papillomavirus (HPV) detection are canonical screening methods for cervical cancer currently. However, there are limitations to these techniques. The aim of the present study was to identify efficient and practical methods for the screening of cervical intraepithelial neoplasia (CIN) and carcinoma. Residual PreservCyt specimens were obtained from 1,000 women who were admitted between August 2013 and December 2015. TCT, human telomerase RNA component (h‑TERC) fluorescent in situ hybridization (FISH), MYC‑specific FISH and surface plasmon resonance (SPR)‑HPV genotyping were performed, followed by histopathology for those patients with positive results in any of the four tests. As a result, 106, 64, 56 and 112 patients were positive in the TCT, h‑TERC, c‑MYC and SPR‑HPV tests, respectively, resulting in 213 being scheduled for histopathology; inflammation was identified in 159 patients, CIN I in 31, CIN II in 14, CIN III in seven and invasive cervical cancer in two patients. Using histopathology as the gold standard, TCT exhibited the highest sensitivity (87.04%), while h‑TERC analysis had the highest specificity (81.76%). Parallel tests demonstrated that the Youden's index of TCT + h‑TERC was the highest (0.49), while the serial analysis reported that TCT + HPV had the highest Youden's index (0.53) compared with any of the biomarkers alone (TCT, 0.50; HPV, 0.29; h‑TERC, 0.47). In conclusion, dual positive TCT and HPV may be an efficient approach for basic screening of cervical lesions. h‑TERC amplification may serve as an auxiliary test to improve the specificity.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Di J, Rutherford S and Chu C: Review of the cervical cancer burden and population-based cervical cancer screening in China. Asian Pac J Cancer Prev. 16:7401–7407. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Wang XZ, Liu KR, Yuan FM, Hou JZ, Zhang JJ and Zhang YZ: An analysis of both high incidence of esophageal and cervical cancer in Yangcheng County, Shanxi Province. China Cancer. 4:259–261. 2011.

4 

Wang Z, Wang J, Fan J, Zhao W, Yang X, Wu L, Li D, Ding L, Wang W, Xu J, et al: Risk factors for cervical intraepithelial neoplasia and cervical cancer in Chinese women: Large study in Jiexiu, Shanxi Province, China. J Cancer. 8:924–932. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Liu Y, Zhang L, Zhao G, Che L, Zhang H and Fang J: The clinical research of Thinprep Cytology Test (TCT) combined with HPV-DNA detection in screening cervical cancer. Cell Mol Biol (Noisy-le-grand). 63:92–95. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Y, Wang Y, Liu L, Guo C, Liu Z and Nie S: Prevalence of human papillomavirus infection and genotyping for population-based cervical screening in developed regions in China. Oncotarget. 7:62411–62424. 2016.PubMed/NCBI

7 

Wang JL, Yang YZ, Dong WW, Sun J, Tao HT, Li RX and Hu Y: Application of human papillomavirus in screening for cervical cancer and precancerous lesions. Asian Pac J Cancer Prev. 14:2979–2982. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Gao K, Eurasian M, Zhang J, Wei Y, Zheng Q, Ye H and Li L: Can genomic amplification of human telomerase gene and C-MYC in liquid-based cytological specimens be used as a method for opportunistic cervical cancer screening? Gynecol Obstet Invest. 80:153–163. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Szarewski A: HPV vaccination and cervical cancer. Curr Oncol Rep. 14:559–567. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Chandra R: Relevance of persistent infection with high-risk HPV genotypes in cervical cancer progression. MLO Med Lab Obs. 45:40, 42, 44. 2013.PubMed/NCBI

11 

Li T, Tang L, Bian D, Jia Y, Huang X and Zhang X: Detection of hTERC and c-MYC genes in cervical epithelial exfoliated cells for cervical cancer screening. Int J Mol Med. 33:1289–1297. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kuglik P, Kasikova K, Smetana J, Vallova V, Lastuvkova A, Moukova L, Cvanova M and Brozova L: Molecular cytogenetic analyses of hTERC (3q26) and MYC (8q24) genes amplifications in correlation with oncogenic human papillomavirus infection in Czech patients with cervical intraepithelial neoplasia and cervical carcinomas. Neoplasma. 62:130–139. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Cao Y, Bryan TM and Reddel RR: Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci. 99:1092–1099. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Bin H, Ruifang W, Ruizhen L, Yiheng L, Zhihong L, Juan L, Chun W, Yanqiu Z and Leiming W: Detention of HPV L1 capsid protein and hTERC gene in screening of cervical cancer. Iran J Basic Med Sci. 16:797–802. 2013.PubMed/NCBI

15 

Ferber MJ, Thorland EC, Brink AA, Rapp AK, Phillips LA, Mcgovern R, Gostout BS, Cheung TH, Chung TK, Fu WY and Smith DI: Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma. Oncogene. 22:7233–7242. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Abba MC, Laguens RM, Dulout FN and Golijow CD: The c-myc activation in cervical carcinomas and HPV 16 infections. Mutat Res. 557:151–158. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Kübler K, Heinenberg S, Rudlowski C, Keyver-Paik MD, Abramian A, Merkelbach-Bruse S, Büttner R, Kuhn W and Schildhaus HU: c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia. Oncotarget. 6:825–835. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zheng X, Liang P, Zheng Y, Yi P, Liu Q, Han J, Huang Y, Zhou Y, Guo J and Li L: Clinical significance of hTERC gene detection in exfoliated cervical epithelial cells for cervical lesions. Int J Gynecol Cancer. 23:785–790. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Zhao WH, Hao M, Cheng XT, Yang X, Wang ZL, Cheng KY, Liu FL and Bai YX: c-myc gene copy number variation in cervical exfoliated cells detected on fluorescence in situ hybridization for cervical cancer screening. Gynecol Obstet Invest. 81:416–423. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Jiang J, Wei LH, Li YL, Wu RF, Xie X, Feng YJ, Zhang G, Zhao C, Zhao Y and Chen Z: Detection of TERC amplification in cervical epithelial cells for the diagnosis of high-grade cervical lesions and invasive cancer: A multicenter study in China. J Mol Diagn. 12:808–817. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Gu Y, Ma C, Zou J, Zhu Y, Yang R, Xu Y and Zhang Y: Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer. Oncotarget. 7:24656–24663. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, Prey M, Raab S, Sherman M, Wilbur D, Wright T Jr, et al: The 2001 Bethesda System: Terminology for reporting results of cervical cytology. JAMA. 287:2114–2119. 2002. View Article : Google Scholar : PubMed/NCBI

23 

He X, Yang P, Wang H, Wang Y and Liu S: Human papillomavirus genotyping by surface plasmon resonance-based test. Clin Lab. 62:2079–2084. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Wang S, Yang H, Zhang H, Yang F, Zhou M, Jia C, Lan Y, Ma Y, Zhou L, Tian S, et al: A surface plasmon resonance--based system to genotype human papillomavirus. Cancer Genet Cytogenet. 200:100–105. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Pan QJ, Hu SY, Guo HQ, Zhang WH, Zhang X, Chen W, Cao J, Jiang Y, Zhao FH and Qiao YL: Liquid-based cytology and human papillomavirus testing: A pooled analysis using the data from 13 population-based cervical cancer screening studies from China. Gynecol Oncol. 133:172–179. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Castle PE, Aslam S and Behrens C: Cervical precancer and cancer risk by human papillomavirus status and cytologic interpretation: Implications for risk-based management. Cancer Epidemiol Biomarkers Prev. 25:1595–1599. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Zappacosta R, Ianieri MM, Buca D, Repetti E, Ricciardulli A and Liberati M: Clinical role of the detection of human telomerase RNA component gene amplification by fluorescence in situ hybridization on liquid-based cervical samples: Comparison with human papillomavirus-DNA testing and histopathology. Acta Cytol. 59:345–354. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Baena-Del Valle JA, Zheng Q, Esopi DM, Rubenstein M, Hubbard GK, Moncaliano MC, Hruszkewycz A, Vaghasia A, Yegnasubramanian S, Wheelan SJ, et al: MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer. J Pathol. 244:11–24. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Penzo M, Ludovini V, Treré D, Siggillino A, Vannucci J, Bellezza G, Crinò L and Montanaro L: Dyskerin and TERC expression may condition survival in lung cancer patients. Oncotarget. 6:21755–21760. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Li Y, Li H, Yao G, Li W, Wang F, Jiang Z and Li M: Inhibition of telomerase RNA (hTR) in cervical cancer by adenovirus-delivered siRNA. Cancer Gene Ther. 14:748–755. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Yuan Y, Zhang J, Cai L, Ding C, Wang X, Chen H, Wang X, Yan J and Lu J: Leptin induces cell proliferation and reduces cell apoptosis by activating c-myc in cervical cancer. Oncol Rep. 29:2291–2296. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Liao LM, Sun XY, Liu AW, Wu JB, Cheng XL, Lin JX, Zheng M and Huang L: Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer. Gynecol Oncol. 133:616–623. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Cui F, Hou J, Huang C, Sun X, Zeng Y, Cheng H, Wang H and Li C: C-Myc regulates radiation-induced G2/M cell cycle arrest and cell death in human cervical cancer cells. J Obstet Gynaecol Res. 43:729–735. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Luan T, Hua Q, Liu X, Xu P, Gu Y, Qian H, Yan L, Xu X, Geng R and Zeng X and Zeng X: PAX1 methylation as a potential biomarker to predict the progression of cervical intraepithelial neoplasia: A meta-analysis of related studies. Int J Gynecol Cancer. 27:1480–1488. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Liou YL, Zhang Y, Liu Y, Cao L, Qin CZ, Zhang TL, Chang CF, Wang HJ, Lin SY, Chu TY, et al: Comparison of HPV genotyping and methylated ZNF582 as triage for women with equivocal liquid-based cytology results. Clin Epigenetics. 7:502015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ji W, Lou W, Hong Z, Qiu L and Di W: Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer. Oncol Lett 17: 2099-2106, 2019.
APA
Ji, W., Lou, W., Hong, Z., Qiu, L., & Di, W. (2019). Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer. Oncology Letters, 17, 2099-2106. https://doi.org/10.3892/ol.2018.9825
MLA
Ji, W., Lou, W., Hong, Z., Qiu, L., Di, W."Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer". Oncology Letters 17.2 (2019): 2099-2106.
Chicago
Ji, W., Lou, W., Hong, Z., Qiu, L., Di, W."Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer". Oncology Letters 17, no. 2 (2019): 2099-2106. https://doi.org/10.3892/ol.2018.9825
Copy and paste a formatted citation
x
Spandidos Publications style
Ji W, Lou W, Hong Z, Qiu L and Di W: Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer. Oncol Lett 17: 2099-2106, 2019.
APA
Ji, W., Lou, W., Hong, Z., Qiu, L., & Di, W. (2019). Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer. Oncology Letters, 17, 2099-2106. https://doi.org/10.3892/ol.2018.9825
MLA
Ji, W., Lou, W., Hong, Z., Qiu, L., Di, W."Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer". Oncology Letters 17.2 (2019): 2099-2106.
Chicago
Ji, W., Lou, W., Hong, Z., Qiu, L., Di, W."Genomic amplification of HPV, h‑TERC and c‑MYC in liquid‑based cytological specimens for screening of cervical intraepithelial neoplasia and cancer". Oncology Letters 17, no. 2 (2019): 2099-2106. https://doi.org/10.3892/ol.2018.9825
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