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Article

Dendritic cell subpopulations in nasopharyngeal cancer

  • Authors:
    • Johan S. Nilsson
    • Milad Abolhalaj
    • Kristina Lundberg
    • Malin Lindstedt
    • Lennart Greiff
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, Skåne University Hospital, Lund SE‑221 85, Sweden, Department of Immunotechnology, Lund University, Lund SE‑221 00, Sweden
  • Pages: 2557-2561
    |
    Published online on: December 14, 2018
       https://doi.org/10.3892/ol.2018.9835
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Abstract

Nasopharyngeal cancer (NPC) is associated with Epstein‑Barr virus (EBV) and EBV antigen may be utilized for therapeutic purposes, including targeting of dendritic cells (DCs). Although DCs may be present in NPC, the information is limited and not up‑to‑date with current knowledge on DC subsets. In the present study, biopsies from untreated NPC were obtained and subjected to multicolor flow‑cytometry focusing on DC subtype markers: CD123 for plasmacytoid DCs (pDCs); and CD1c and CD141 for myeloid DCs (mDCs). Furthermore, subset‑specific expression of the C‑lectin receptor (CLR) CD207 (also termed langerin) was assessed. pDCs and mDCs were detected in the NPC lesions, contributing to a frequency mean average of 0.78% of CD45+ leukocytes in situ. Different subpopulations, previously not described in NPC, were observed, including: CD123+ pDCs; CD1c+ mDCs; CD141+ mDCs; and CD1c‑CD141‑ mDCs. A high frequency of CD1c+ mDCs expressing CD207 was observed, compared with other subsets. In conclusion, different DC subsets are present in NPC lesions. The CLR CD207, a selective endocytic marker on CD1c+ mDCs, may be targeted for therapeutic purposes to facilitate cross‑presentation of antigens and aid cell‑mediated antitumor effects.
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Copy and paste a formatted citation
Spandidos Publications style
Nilsson JS, Abolhalaj M, Lundberg K, Lindstedt M and Greiff L: Dendritic cell subpopulations in nasopharyngeal cancer. Oncol Lett 17: 2557-2561, 2019.
APA
Nilsson, J.S., Abolhalaj, M., Lundberg, K., Lindstedt, M., & Greiff, L. (2019). Dendritic cell subpopulations in nasopharyngeal cancer. Oncology Letters, 17, 2557-2561. https://doi.org/10.3892/ol.2018.9835
MLA
Nilsson, J. S., Abolhalaj, M., Lundberg, K., Lindstedt, M., Greiff, L."Dendritic cell subpopulations in nasopharyngeal cancer". Oncology Letters 17.2 (2019): 2557-2561.
Chicago
Nilsson, J. S., Abolhalaj, M., Lundberg, K., Lindstedt, M., Greiff, L."Dendritic cell subpopulations in nasopharyngeal cancer". Oncology Letters 17, no. 2 (2019): 2557-2561. https://doi.org/10.3892/ol.2018.9835
Copy and paste a formatted citation
x
Spandidos Publications style
Nilsson JS, Abolhalaj M, Lundberg K, Lindstedt M and Greiff L: Dendritic cell subpopulations in nasopharyngeal cancer. Oncol Lett 17: 2557-2561, 2019.
APA
Nilsson, J.S., Abolhalaj, M., Lundberg, K., Lindstedt, M., & Greiff, L. (2019). Dendritic cell subpopulations in nasopharyngeal cancer. Oncology Letters, 17, 2557-2561. https://doi.org/10.3892/ol.2018.9835
MLA
Nilsson, J. S., Abolhalaj, M., Lundberg, K., Lindstedt, M., Greiff, L."Dendritic cell subpopulations in nasopharyngeal cancer". Oncology Letters 17.2 (2019): 2557-2561.
Chicago
Nilsson, J. S., Abolhalaj, M., Lundberg, K., Lindstedt, M., Greiff, L."Dendritic cell subpopulations in nasopharyngeal cancer". Oncology Letters 17, no. 2 (2019): 2557-2561. https://doi.org/10.3892/ol.2018.9835
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