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Article Open Access

Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis

  • Authors:
    • Xingkai Liu
    • Chang Su
    • Jing Xu
    • Dan Zhou
    • He Yan
    • Wei Li
    • Guihui Chen
    • Nan Zhang
    • Dahai Xu
    • Haixia Hu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Cardiovascular Disease Center, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pediatrics, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pathology, Jilin City People's Hospital, Jilin, Jilin 132000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2308-2316
    |
    Published online on: December 19, 2018
       https://doi.org/10.3892/ol.2018.9850
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Abstract

The present study aimed to explore the association between immunohistochemical matrix metalloproteinase‑9 (MMP‑9) expression and the clinicopathological characteristics of patients with papillary thyroid carcinoma (PTC), and to determine whether it may be used as a diagnostic or prognostic tool for PTC. Immunohistochemical staining of MMP‑9 was performed in thyroid tissues obtained from 112 patients with PTC and 42 subjects with benign thyroid nodules (BTNs). The receiver operating characteristic curve was used to evaluate the legitimacy of MMP‑9 as a diagnostic tool for PTC, and a predictor for structurally persistent/recurrent disease (SPRD) and disease status. Cox regression was applied to identify the risk factors of disease status and SPRD. The present study revealed that MMP‑9 was overexpressed in PTC tissues, compared with in BTN tissues. Furthermore, MMP‑9 scores yielded an area under the curve (AUC) of 0.842 (95% CI, 0.776‑0.908) for differentially diagnosing PTC from BTN. In addition, the MMP‑9 score was greater if patients previously had central lymph node metastasis, lateral lymph node metastasis or an advanced tumor‑node‑metastasis stage (III+IV). When MMP‑9 was employed to predict disease status and SPRD, an AUC of 0.811 (95% CI, 0.706‑0.917) and 0.806 (95% CI, 0.620‑0.992) was obtained, respectively. A tumor size of >2 cm and an MMP‑9 staining score of ≥6 were independent risk factors for predicting disease status, whereas vascular invasion and an MMP‑9 staining score of ≥8 were risk factors for predicting SPRD. Furthermore, an MMP‑9 staining score of ≥6 and ≥8 indicated shortened disease‑free survival and survival without SPRD, respectively. In conclusion, the assessment of MMP‑9 expression in thyroid carcinoma samples may represent a potential and supplementary tool for the diagnosis and prognostic prediction of PTC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Su C, Xu J, Zhou D, Yan H, Li W, Chen G, Zhang N, Xu D, Hu H, Hu H, et al: Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis. Oncol Lett 17: 2308-2316, 2019.
APA
Liu, X., Su, C., Xu, J., Zhou, D., Yan, H., Li, W. ... Hu, H. (2019). Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis. Oncology Letters, 17, 2308-2316. https://doi.org/10.3892/ol.2018.9850
MLA
Liu, X., Su, C., Xu, J., Zhou, D., Yan, H., Li, W., Chen, G., Zhang, N., Xu, D., Hu, H."Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis". Oncology Letters 17.2 (2019): 2308-2316.
Chicago
Liu, X., Su, C., Xu, J., Zhou, D., Yan, H., Li, W., Chen, G., Zhang, N., Xu, D., Hu, H."Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis". Oncology Letters 17, no. 2 (2019): 2308-2316. https://doi.org/10.3892/ol.2018.9850
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Su C, Xu J, Zhou D, Yan H, Li W, Chen G, Zhang N, Xu D, Hu H, Hu H, et al: Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis. Oncol Lett 17: 2308-2316, 2019.
APA
Liu, X., Su, C., Xu, J., Zhou, D., Yan, H., Li, W. ... Hu, H. (2019). Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis. Oncology Letters, 17, 2308-2316. https://doi.org/10.3892/ol.2018.9850
MLA
Liu, X., Su, C., Xu, J., Zhou, D., Yan, H., Li, W., Chen, G., Zhang, N., Xu, D., Hu, H."Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis". Oncology Letters 17.2 (2019): 2308-2316.
Chicago
Liu, X., Su, C., Xu, J., Zhou, D., Yan, H., Li, W., Chen, G., Zhang, N., Xu, D., Hu, H."Immunohistochemical analysis of matrix metalloproteinase‑9 predicts papillary thyroid carcinoma prognosis". Oncology Letters 17, no. 2 (2019): 2308-2316. https://doi.org/10.3892/ol.2018.9850
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