Open Access

Prognostic evaluation of patients with resectable lung cancer using systemic inflammatory response parameters

  • Authors:
    • Jie Zhu
    • Lian Lian
    • Hualong Qin
    • Wen‑Jie Wang
    • Rui Ren
    • Meng‑Dan Xu
    • Kai Chen
    • Weiming Duan
    • Fei‑Ran Gong
    • Min Tao
    • Qiaoming Zhi
    • Meng‑Yao Wu
    • Wei Li
  • View Affiliations

  • Published online on: December 20, 2018     https://doi.org/10.3892/ol.2018.9858
  • Pages: 2244-2256
  • Copyright : © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Lung cancer is one of the leading causes of cancer‑associated mortality. C‑reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), neutrophil‑lymphocyte ratio (NLR) and platelet‑to‑lymphocyte ratio (PLR) have been identified as general parameters for systemic inflammatory response (SIR). Furthermore, these parameters are also associated with tumor development and metastasis. The present study aimed to investigate the predictive values of these SIR parameters in patients with resectable lung cancer. In total, 101 patients with resectable lung cancer were recruited in the present study. The patients were divided into two groups according to the median value of pre‑treatment CRP, ALB, GLB, LDH, NLR or PLR values. The post‑/pre‑treatment ratios were defined as the ratio of pre‑treatment blood parameter values and the corresponding values obtained following therapy. A ratio of ≤1.1 indicated that the values were not increased, while a ratio of >1.1 suggested that the values were increased following treatment. Patients with lower pre‑treatment ALB levels had poorer overall survival (OS) rates, whereas GLB, LDH, CRP, NLR or PLR levels were not associated with outcomes. Whole course treatment (surgery combined with adjuvant chemotherapy) significantly increased the value of ALB, but decreased the value of NLR, whereas it had no effect on the values of LDH, CRP or PLR. Post‑/pre‑treatment LDH and PLR were associated with outcomes. Post‑/pre‑treatment ALB, GLB, CRP and NLR were not associated with outcomes. Multivariate analysis revealed that a low pre‑treatment ALB level and increased post‑/pre‑treatment PLR were independent risk factors affecting OS. The receiver operating characteristic curve analysis demonstrated that an ALB value of 47.850 g/l was considered to be the optimal cut‑off value for prognosis; the sensitivity was 28.8% and specificity was 95.9%. It was suggested that the pre‑treatment ALB and post‑/pre‑treatment PLR may be potential prognostic factors in resectable lung cancer.
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February 2019
Volume 17 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Zhu, J., Lian, L., Qin, H., Wang, W., Ren, R., Xu, M. ... Li, W. (2019). Prognostic evaluation of patients with resectable lung cancer using systemic inflammatory response parameters. Oncology Letters, 17, 2244-2256. https://doi.org/10.3892/ol.2018.9858
MLA
Zhu, J., Lian, L., Qin, H., Wang, W., Ren, R., Xu, M., Chen, K., Duan, W., Gong, F., Tao, M., Zhi, Q., Wu, M., Li, W."Prognostic evaluation of patients with resectable lung cancer using systemic inflammatory response parameters". Oncology Letters 17.2 (2019): 2244-2256.
Chicago
Zhu, J., Lian, L., Qin, H., Wang, W., Ren, R., Xu, M., Chen, K., Duan, W., Gong, F., Tao, M., Zhi, Q., Wu, M., Li, W."Prognostic evaluation of patients with resectable lung cancer using systemic inflammatory response parameters". Oncology Letters 17, no. 2 (2019): 2244-2256. https://doi.org/10.3892/ol.2018.9858