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Case Report Open Access

ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report

  • Authors:
    • Xiaojing Xu
    • Hong Li
    • Ke Peng
    • Yiyi Yu
    • Lingli Chen
    • Yong Fang
    • Yihong Sun
    • Yingyong Hou
    • Tianshu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Oncology, Jiahui International Hospital, Shanghai 200032, P.R. China, Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2370-2376
    |
    Published online on: December 21, 2018
       https://doi.org/10.3892/ol.2018.9865
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Abstract

Epithelioid inflammatory myofibroblastic sarcoma (EIMS), a specific subtype of inflammatory myofibroblastic tumors (IMT), is a relatively rare malignant mesenchymal tumor with clinical features of positive anaplastic lymphoma kinase (ALK), high invasiveness, treatment resistance and poor prognosis. Therefore, ALK inhibitors represent specific effective drugs for patients with this type of tumor. However, acquired resistance remains inevitable without a clear mechanism of action and therapeutic strategy to counteract this. Herein, a chromosomal ALK‑G1269A mutation was identified using next‑generation sequencing (NGS) and the mutation was confirmed by Sanger sequencing in a patient with crizotinib‑resistant EIMS who benefited from treatment with the second‑generation ALK inhibitor AP26113. To the best of our knowledge, a few rare cases of crizotinib‑resistance in IMTs have been reported, and there are no reported cases in EIMS. In this article, we present the case of a patient with a secondary mutation of ALK‑G1269A in EIMS, and suggest that AP26113 (Brigatinib) may represent an ideal treatment for these patients.
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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Li H, Peng K, Yu Y, Chen L, Fang Y, Sun Y, Hou Y and Liu T: ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report. Oncol Lett 17: 2370-2376, 2019.
APA
Xu, X., Li, H., Peng, K., Yu, Y., Chen, L., Fang, Y. ... Liu, T. (2019). ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report. Oncology Letters, 17, 2370-2376. https://doi.org/10.3892/ol.2018.9865
MLA
Xu, X., Li, H., Peng, K., Yu, Y., Chen, L., Fang, Y., Sun, Y., Hou, Y., Liu, T."ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report". Oncology Letters 17.2 (2019): 2370-2376.
Chicago
Xu, X., Li, H., Peng, K., Yu, Y., Chen, L., Fang, Y., Sun, Y., Hou, Y., Liu, T."ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report". Oncology Letters 17, no. 2 (2019): 2370-2376. https://doi.org/10.3892/ol.2018.9865
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Li H, Peng K, Yu Y, Chen L, Fang Y, Sun Y, Hou Y and Liu T: ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report. Oncol Lett 17: 2370-2376, 2019.
APA
Xu, X., Li, H., Peng, K., Yu, Y., Chen, L., Fang, Y. ... Liu, T. (2019). ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report. Oncology Letters, 17, 2370-2376. https://doi.org/10.3892/ol.2018.9865
MLA
Xu, X., Li, H., Peng, K., Yu, Y., Chen, L., Fang, Y., Sun, Y., Hou, Y., Liu, T."ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report". Oncology Letters 17.2 (2019): 2370-2376.
Chicago
Xu, X., Li, H., Peng, K., Yu, Y., Chen, L., Fang, Y., Sun, Y., Hou, Y., Liu, T."ALK‑G1269A mutation in epithelioid inflammatory myofibroblastic sarcoma after progression on crizotinib: A case report". Oncology Letters 17, no. 2 (2019): 2370-2376. https://doi.org/10.3892/ol.2018.9865
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