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Article

MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas

  • Authors:
    • Chao Tang
    • Chunyu Zhong
    • Zixiang Cong
    • Jin Yang
    • Guodao Wen
    • Junhao Zhu
    • Chiyuan Ma
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, P.R. China, School of Medicine, Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China, Department of Neurosurgery, Dongguan Donghua Hospital, Dongguan, Guangdong 523000, P.R. China
  • Pages: 3495-3502
    |
    Published online on: February 1, 2019
       https://doi.org/10.3892/ol.2019.10006
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Abstract

Overactivation of the Gs‑mediated pathway by mutations of the G‑protein α subunit (Gsα), a gsp oncogene, results in increased growth hormone (GH) hypersecretion and reduced tumor volume in patients with GH‑secreting pituitary tumors. However, the mechanism underlying the clinical characteristics of gsp oncogene requires further investigation. Cyclic adenosine monophosphate‑responsive element binding (CREB), as a downstream target gene of gsp oncogene, is implicated in activating maternally expressed gene 3 (MEG3). The present study proposes that gsp oncogene mediates MEG3‑regulating GH hypersecretion, resulting in the small tumor size of GH‑secreting tumors. Therefore, the present study detected Gsα mutations by polymerase chain reaction in GH‑secreting tumors, and revealed that Gsα mutations were observed in 7/25 (28%) GH‑secreting tumors. Gsp‑positive tumors indicated significantly increased levels of phosphorylated p‑CREB (P<0.0001) and MEG3 (P=0.039), compared with gsp‑negative tumors. The results indicated that MEG3 levels were positively correlated with GH and IGF‑1 levels, and negatively correlated with the tumor volume of GH‑secreting tumors. The group with gsp‑positive or with high MEG3 expression indicated a significantly reduced proportion of invasiveness and lower Ki‑67 index, compared with the gsp‑negative or low MEG3 expression group. In conclusion, gsp oncogene may mediate MEG3 by promoting GH hypersecretion, resulting in smaller tumors, as well as suppressing proliferation and invasiveness of GH‑secreting pituitary tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Tang C, Zhong C, Cong Z, Yang J, Wen G, Zhu J and Ma C: MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas. Oncol Lett 17: 3495-3502, 2019.
APA
Tang, C., Zhong, C., Cong, Z., Yang, J., Wen, G., Zhu, J., & Ma, C. (2019). MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas. Oncology Letters, 17, 3495-3502. https://doi.org/10.3892/ol.2019.10006
MLA
Tang, C., Zhong, C., Cong, Z., Yang, J., Wen, G., Zhu, J., Ma, C."MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas". Oncology Letters 17.3 (2019): 3495-3502.
Chicago
Tang, C., Zhong, C., Cong, Z., Yang, J., Wen, G., Zhu, J., Ma, C."MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas". Oncology Letters 17, no. 3 (2019): 3495-3502. https://doi.org/10.3892/ol.2019.10006
Copy and paste a formatted citation
x
Spandidos Publications style
Tang C, Zhong C, Cong Z, Yang J, Wen G, Zhu J and Ma C: MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas. Oncol Lett 17: 3495-3502, 2019.
APA
Tang, C., Zhong, C., Cong, Z., Yang, J., Wen, G., Zhu, J., & Ma, C. (2019). MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas. Oncology Letters, 17, 3495-3502. https://doi.org/10.3892/ol.2019.10006
MLA
Tang, C., Zhong, C., Cong, Z., Yang, J., Wen, G., Zhu, J., Ma, C."MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas". Oncology Letters 17.3 (2019): 3495-3502.
Chicago
Tang, C., Zhong, C., Cong, Z., Yang, J., Wen, G., Zhu, J., Ma, C."MEG3 is associated with gsp oncogene regulation of growth hormone hypersecretion, proliferation and invasiveness of human GH‑secreting adenomas". Oncology Letters 17, no. 3 (2019): 3495-3502. https://doi.org/10.3892/ol.2019.10006
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