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Article

Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer

  • Authors:
    • Shuang Liu
    • Hailing Dong
    • Jianhua Wu
    • Cuiju Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, P.R. China, Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Animal Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 3960-3964
    |
    Published online on: February 7, 2019
       https://doi.org/10.3892/ol.2019.10026
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Abstract

The histone methyltransferase SET8 is regulated by microRNA‑502 through the binding site in its 3'‑untranslated region, and the rs16917496 polymorphism at the miR‑502‑binding site in the SET8 gene has been implicated in a number of cancer types. The rs16917496 polymorphism including CC, CT and TT genotypes was analyzed in patients with colorectal cancer; the CC genotype was identified to be independently associated with longer post‑operative survival times using multivariate analysis (relative risk, 2.406; 95% confidence interval, 1.017‑5.691; P=0.046). In addition, decreased SET8 expression was associated with the SET8 CC genotype and longer survival times for patients with colorectal cancer. The results of the present study indicated that miR‑502 mediates SET8 expression at least partly by altering the binding affinity between miR‑502 and SET8 so as to modify the colorectal cancer outcome. The results indicate that SET8 may be a novel target for colorectal cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Liu S, Dong H, Wu J and Wang C: Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer. Oncol Lett 17: 3960-3964, 2019.
APA
Liu, S., Dong, H., Wu, J., & Wang, C. (2019). Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer. Oncology Letters, 17, 3960-3964. https://doi.org/10.3892/ol.2019.10026
MLA
Liu, S., Dong, H., Wu, J., Wang, C."Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer". Oncology Letters 17.4 (2019): 3960-3964.
Chicago
Liu, S., Dong, H., Wu, J., Wang, C."Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer". Oncology Letters 17, no. 4 (2019): 3960-3964. https://doi.org/10.3892/ol.2019.10026
Copy and paste a formatted citation
x
Spandidos Publications style
Liu S, Dong H, Wu J and Wang C: Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer. Oncol Lett 17: 3960-3964, 2019.
APA
Liu, S., Dong, H., Wu, J., & Wang, C. (2019). Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer. Oncology Letters, 17, 3960-3964. https://doi.org/10.3892/ol.2019.10026
MLA
Liu, S., Dong, H., Wu, J., Wang, C."Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer". Oncology Letters 17.4 (2019): 3960-3964.
Chicago
Liu, S., Dong, H., Wu, J., Wang, C."Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer". Oncology Letters 17, no. 4 (2019): 3960-3964. https://doi.org/10.3892/ol.2019.10026
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