Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer

Liu,Shuang; Dong,Hailing; Wu,Jianhua; Wang,Cuiju

doi:10.3892/ol.2019.10026

Association of an miR‑502‑binding site polymorphism in the 3'‑untranslated region of SET8 with colorectal cancer

Authors:
- Shuang Liu
- Hailing Dong
- Jianhua Wu
- Cuiju Wang
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Affiliations: Department of Pathology, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, P.R. China, Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Animal Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
Published online on: February 7, 2019 https://doi.org/10.3892/ol.2019.10026
Pages: 3960-3964

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Abstract

The histone methyltransferase SET8 is regulated by microRNA‑502 through the binding site in its 3'‑untranslated region, and the rs16917496 polymorphism at the miR‑502‑binding site in the SET8 gene has been implicated in a number of cancer types. The rs16917496 polymorphism including CC, CT and TT genotypes was analyzed in patients with colorectal cancer; the CC genotype was identified to be independently associated with longer post‑operative survival times using multivariate analysis (relative risk, 2.406; 95% confidence interval, 1.017‑5.691; P=0.046). In addition, decreased SET8 expression was associated with the SET8 CC genotype and longer survival times for patients with colorectal cancer. The results of the present study indicated that miR‑502 mediates SET8 expression at least partly by altering the binding affinity between miR‑502 and SET8 so as to modify the colorectal cancer outcome. The results indicate that SET8 may be a novel target for colorectal cancer therapy.

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1	Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012 v1.0. IARC CancerBase. (11): IARC, Lyon. 2014, http://globocan.iarcfr
2	Center MM, Jemal A and Ward E: International trends in colorectal cancer incidence rates. CancerEpidemiol Biomarkers Prev. 18:1688–1694. 2009. View Article : Google Scholar
3	World Cancer Research Fund, American Institute for Cancer Research Imperial College, London, . WCRF/AICR Systematic Literature Review Continuous Update Project Report: The Associations between Food, Nutrition and Physical Activity and the Risk of Colorectal Cancer. https://www.wcrf.org/sites/default/files/SLR_colorectal_cancer_2010.pdfOctober. 2010
4	Bishehsari F, Mahdavinia M, Vacca M, Malekzadeh R and Mariani-Costantini R: Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention. World J Gastroenterol. 20:6055–6072. 2014. View Article : Google Scholar : PubMed/NCBI
5	Migliore L, Migheli F, Spisni R and Coppedè F: Genetics, cytogenetics, and epigenetics of colorectal cancer. J Biomed Biotechnol. 2011:7923622011. View Article : Google Scholar : PubMed/NCBI
6	Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, Berndt SI, Bézieau S, Brenner H, Butterbach K, et al: Colon cancer family registry and the genetics and epidemiology of colorectal cancer consortium: Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis. Gastroenterology. 144:799–807. 2013. View Article : Google Scholar : PubMed/NCBI
7	Markowitz SD and Bertagnolli MM: Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med. 361:2449–2460. 2009. View Article : Google Scholar : PubMed/NCBI
8	Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI
9	Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI
10	Zeng Y, Yi R and Cullen BR: MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci USA. 100:9779–9784. 2003. View Article : Google Scholar : PubMed/NCBI
11	Zeng Y, Wagner EJ and Cullen BR: Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell. 9:1327–1333. 2002. View Article : Google Scholar : PubMed/NCBI
12	Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, et al: A SNP in a let-7 microRNA complementary site in the KRAS 3′ untranslated region increases non-small cell lung cancer risk. Cancer Res. 68:8535–8540. 2008. View Article : Google Scholar : PubMed/NCBI
13	Brendle A, Lei H, Brandt A, Johansson R, Enquist K, Henriksson R, Hemminki K, Lenner P and Försti A: Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. Carcinogenesis. 29:1394–1399. 2008. View Article : Google Scholar : PubMed/NCBI
14	Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA and Zhang Y: Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr Biol. 12:1086–1099. 2002. View Article : Google Scholar : PubMed/NCBI
15	Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, et al: PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell. 9:1201–1213. 2002. View Article : Google Scholar : PubMed/NCBI
16	Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW and Rice JC: Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev. 24:2531–2542. 2010. View Article : Google Scholar : PubMed/NCBI
17	Tardat M, Murr R, Herceg Z, Sardet C and Julien E: PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J Cell Biol. 179:1413–1426. 2007. View Article : Google Scholar : PubMed/NCBI
18	Jorgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K and Sorensen CS: The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol. 179:1337–1345. 2007. View Article : Google Scholar : PubMed/NCBI
19	Abbas T, Shibata E, Park J, Jha S, Karnani N and Dutta A: CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Mol Cell. 40:9–21. 2010. View Article : Google Scholar : PubMed/NCBI
20	Huen MS, Sy SM, van Deursen JM and Chen J: Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem. 283:11073–11077. 2008. View Article : Google Scholar : PubMed/NCBI
21	Dulev S, Tkach J, Lin S and Batada NN: SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1. EMBO Rep. 15:1163–1174. 2014. View Article : Google Scholar : PubMed/NCBI
22	Yang F, Sun L, Li Q, Han X, Lei L, Zhang H and Shang Y: SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. EMBO J. 31:110–123. 2012. View Article : Google Scholar : PubMed/NCBI
23	Wang C, Guo Z, Wu C, Li Y and Kang S: A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the risk of epithelial ovarian cancer. Cancer Genet. 205:373–376. 2012. View Article : Google Scholar : PubMed/NCBI
24	Ding C, Li R, Peng J, Li S and Guo Z: A polymorphism at the miR-502 binding site in the 3′ untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer. Exp Ther Med. 3:689–692. 2012. View Article : Google Scholar : PubMed/NCBI
25	Guo Z, Wu C, Wang X, Wang C, Zhang R and Shan B: A polymorphism at the miR-502 binding site in the 3′-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome. Int J Cancer. 131:1318–1322. 2012. View Article : Google Scholar : PubMed/NCBI
26	Diao L, Su H, Wei G, Li T, Gao Y, Zhao G and Guo Z: Prognostic value of microRNA 502 binding site SNP in the 3′-untranslated region of the SET8 gene in patients with non-Hodgkin's lymphoma. Tumori. 100:553–558. 2014. View Article : Google Scholar : PubMed/NCBI
27	Shi X, Kachirskaia I, Yamaguchi H, West LE, Wen H, Wang EW, Dutta S, Appella E and Gozani O: Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell. 27:636–646. 2007. View Article : Google Scholar : PubMed/NCBI
28	Dhami GK, Liu H, Galka M, Voss C, Wei R, Muranko K, Kaneko T, Cregan SP, Li L and Li SS: Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis. Mol Cell. 50:565–576. 2013. View Article : Google Scholar : PubMed/NCBI
29	Landi D, Gemignani F, Naccarati A, Pardini B, Vodicka P, Vodickova L, Novotny J, Forsti A, Hemminki K, Canzian F and Landi S: Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer. Carcinogenesis. 29:579–584. 2008. View Article : Google Scholar : PubMed/NCBI
30	Gao Y, He Y, Ding J, Wu K, Hu B, Liu Y, Wu Y, Guo B, Shen Y, Landi D, et al: An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3′ untranslated region confers risk for hepatocellular carcinoma. Carcinogenesis. 30:2064–2069. 2009. View Article : Google Scholar : PubMed/NCBI
31	Horikawa Y, Wood CG, Yang H, Zhao H, Ye Y, Gu J, Lin J, Habuchi T and Wu X: Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res. 14:7956–7962. 2008. View Article : Google Scholar : PubMed/NCBI
32	Hu Z, Chen J, Tian T, Zhou X, Gu H, Xu L, Zeng Y, Miao R, Jin G, Ma H, et al: Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest. 118:2600–2608. 2008.PubMed/NCBI
33	Song F, Zheng H, Liu B, Wei S, Dai H, Zhang L, Calin GA, Hao X, Wei Q, Zhang W and Chen K: An miR-502-binding site single-nucleotide polymorphism in the 3′-untranslated region of the SET8 gene is associated with early age of breast cancer onset. Clin Cancer Res. 19:6292–6300. 2009. View Article : Google Scholar