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Case Report

Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report

  • Authors:
    • Takeshi Azuma
    • Tohru Sugihara
    • Sachi Honda
    • Uran Yoshizaki
    • Fusako Niimi
    • Ibuki Tsuru
    • Haruki Kume
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tokyo Metropolitan Tama Medical Center, Fuchu, Tokyo 183‑0042, Japan, Department of Urology, The University of Tokyo Graduate School of Medicine, Tokyo 113‑8654, Japan
  • Pages: 4011-4015
    |
    Published online on: February 8, 2019
       https://doi.org/10.3892/ol.2019.10027
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Abstract

Sequential therapy using tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin inhibitors is the mainstay of treatment for metastatic renal cell carcinoma. Recently, anti‑programmed death‑1 (PD‑1) antibody, a type of immune checkpoint inhibitor, was approved for use against metastatic renal cell carcinoma. In the present report, two cases of TKI‑refractory metastatic renal cell carcinoma which regained sensitivity to TKI after immunotherapy with nivolumab were described. In one case, a third challenge with axitinib after nivolumab treatment resulted in tumor shrinkage, although the second challenge with axitinib immediately before nivolumab treatment had no effect. In another case, a second challenge with pazopanib after nivolumab slightly reduced lung metastasis, which was refractory to pazopanib before nivolumab treatment. These cases suggest that nivolumab can influence the response to subsequent TKI treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Azuma T, Sugihara T, Honda S, Yoshizaki U, Niimi F, Tsuru I and Kume H: Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report. Oncol Lett 17: 4011-4015, 2019.
APA
Azuma, T., Sugihara, T., Honda, S., Yoshizaki, U., Niimi, F., Tsuru, I., & Kume, H. (2019). Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report. Oncology Letters, 17, 4011-4015. https://doi.org/10.3892/ol.2019.10027
MLA
Azuma, T., Sugihara, T., Honda, S., Yoshizaki, U., Niimi, F., Tsuru, I., Kume, H."Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report". Oncology Letters 17.4 (2019): 4011-4015.
Chicago
Azuma, T., Sugihara, T., Honda, S., Yoshizaki, U., Niimi, F., Tsuru, I., Kume, H."Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report". Oncology Letters 17, no. 4 (2019): 4011-4015. https://doi.org/10.3892/ol.2019.10027
Copy and paste a formatted citation
x
Spandidos Publications style
Azuma T, Sugihara T, Honda S, Yoshizaki U, Niimi F, Tsuru I and Kume H: Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report. Oncol Lett 17: 4011-4015, 2019.
APA
Azuma, T., Sugihara, T., Honda, S., Yoshizaki, U., Niimi, F., Tsuru, I., & Kume, H. (2019). Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report. Oncology Letters, 17, 4011-4015. https://doi.org/10.3892/ol.2019.10027
MLA
Azuma, T., Sugihara, T., Honda, S., Yoshizaki, U., Niimi, F., Tsuru, I., Kume, H."Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report". Oncology Letters 17.4 (2019): 4011-4015.
Chicago
Azuma, T., Sugihara, T., Honda, S., Yoshizaki, U., Niimi, F., Tsuru, I., Kume, H."Metastatic renal cell carcinoma regains sensitivity to tyrosine kinase inhibitor after nivolumab treatment: A case report". Oncology Letters 17, no. 4 (2019): 4011-4015. https://doi.org/10.3892/ol.2019.10027
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