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Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3

  • Authors:
    • Ting Yuan
    • Feng Zhang
    • Xiangxiang Zhou
    • Ying Li
    • Ya Zhang
    • Yangyang Xu
    • Xin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3719-3726
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    Published online on: February 8, 2019
       https://doi.org/10.3892/ol.2019.10029
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Abstract

Proteasome inhibitors represent a novel class of drugs that have clinical efficacy against hematological and solid cancer types, including acute myeloid leukaemia, myelodysplastic syndrome an non‑small cell lung cancer. It has been demonstrated that the anti‑apoptotic protein B‑cell lymphoma‑2‑associated athanogene 3 (BAG3) is induced by proteasome inhibitors in various cancer cells and serves an important role in chemotherapy resistance. The phosphatidylinositol 3‑kinase (PI3K)/RAC‑α serine/threonine‑protein kinase (AKT) pathway is constitutively activated in a number of lymphoid malignancy types, including diffuse large B‑cell lymphoma (DLBCL) and Burkitt lymphoma. In the present study, the aim was to elucidate the role of the PI3K/AKT signaling pathway in the induction of BAG3, following exposure to a proteasome inhibitor in DLBCL cell lines. Bortezomib and MG132 were used as proteasome inhibitors. Western blotting was used to evaluate the roles of proteasome inhibitors and the PI3K/AKT pathway in BAG3 induction in DLBCL cells (LY1 and LY8), and LY294002 was used to block the PI3K/AKT pathway. Cell viability was detected using a Cell Counting Kit‑8 assay. Apoptosis of LY1 and LY8 cells was quantified by Annexin V/7‑amino‑actinomycin D flow cytometry. The BAG3 protein was markedly induced upon exposure to bortezomib and MG132 in a dose‑dependent manner. The PI3K/AKT inhibitor LY294002 significantly suppressed the induction of BAG3 by proteasome inhibitors. Inhibition of the PI3K/AKT pathway decreased the proliferation and increased the apoptosis induced by proteasome inhibitors. The present results indicated that the PI3K/AKT pathway is associated with the activation of BAG3 expression in DLBCL cells, and is involved in the protective response against proteasome inhibition.
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View References

1 

A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The non-hodgkin's lymphoma classification project. Blood. 89:3909–3918. 1997.

2 

McGuire S: World cancer report 2014. (Geneva, Switzerland). World health organization, International agency for research on cancer, WHO Press 2015. Adv Nutr. 7:418–419. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Sarkozy C and Sehn LH: Management of relapsed/refractory DLBCL. Best Pract Res Clin Haematol. 31:209–216. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Teras LR, DeSantis CE, Cerhan JR, Morton LM, Jemal A and Flowers CR: 2016 US lymphoid malignancy statistics by World Health Organization subtypes. CA Cancer J Clin. Sep 12–2016.(Epub ahead of print). doi: 10.3322/caac.21357. View Article : Google Scholar : PubMed/NCBI

5 

Sharma A and Bhimji SS: Bortezomib. StatPearls [Internet]. Treasure Island (FL) StatPearls Publishing. Oct 27–2018.

6 

Camicia R, Winkler HC and Hassa PO: Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: A comprehensive review. Mol Cancer. 14:2072015. View Article : Google Scholar : PubMed/NCBI

7 

Yazbeck V, Shafer D, Perkins EB, Coppola D, Sokol L, Richards KL, Shea T, Ruan J, Parekh S, Strair R, et al: A phase II trial of bortezomib and vorinostat in mantle cell lymphoma and diffuse large B-cell lymphoma. Clin Lymphoma Myeloma Leuk. 18:569–575. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Evens AM, Rosen ST, Helenowski I, Kline J, Larsen A, Colvin J, Winter JN, van Besien KM, Gordon LI and Smith SM: A phase I/II trial of bortezomib combined concurrently with gemcitabine for relapsed or refractory DLBCL and peripheral T-cell lymphomas. Br J Haematol. 163:55–61. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Kung AL, Davies FE, Morgan G, Akiyama M, Shringarpure R, Munshi NC, et al: Antimyeloma activity of heat shock protein-90 inhibition. Blood. 107:1092–1100. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Nencioni A, Hua F, Dillon CP, Yokoo R, Scheiermann C, Cardone MH, Barbieri E, Rocco I, Garuti A, Wesselborg S, et al: Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis. Blood. 105:3255–3262. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Wang HQ, Liu HM, Zhang HY, Guan Y and Du ZX: Transcriptional upregulation of BAG3 upon proteasome inhibition. Biochem Biophys Res Commun. 365:381–385. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Sondermann H, Scheufler C, Schneider C, Hohfeld J, Hartl FU and Moarefi I: Structure of a Bag/Hsc70 complex: Convergent functional evolution of Hsp70 nucleotide exchange factors. Science. 291:1553–1557. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Shi H, Xu H, Li Z, Zhen Y, Wang B, Huo S, Xiao R and Xu Z: BAG3 regulates cell proliferation, migration, and invasion in human colorectal cancer. Tumour Biol. 37:5591–5597. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Zhu H, Wu W, Fu Y, Shen W, Miao K, Hong M, Xu W, Young KH, Liu P and Li J: Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia. Ann Hematol. 93:425–435. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Festa M, Del Valle L, Khalili K, Franco R, Scognamiglio G, Graziano V, De Laurenzi V, Turco MC and Rosati A: BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Am J Pathol. 178:2504–2512. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Gentilella A and Khalili K: BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner. J Biol Chem. 286:9205–9215. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Liao Q, Ozawa F, Friess H, Zimmermann A, Takayama S, Reed JC, Kleeff J and Büchler MW: The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. FEBS Lett. 503:151–157. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Romano MF, Festa M, Petrella A, Rosati A, Pascale M, Bisogni R, Poggi V, Kohn EC, Venuta S, Turco MC, et al: BAG3 protein regulates cell survival in childhood acute lymphoblastic leukemia cells. Cancer Biol Ther. 2:508–510. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Chiappetta G, Ammirante M, Basile A, Rosati A, Festa M, Monaco M, Vuttariello E, Pasquinelli R, Arra C, Zerilli M, et al: The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand. J Clin Endocrinol Metab. 92:1159–1163. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Staibano S, Mascolo M, Di Benedetto M, Vecchione ML, Ilardi G, Di Lorenzo G, Autorino R, Salerno V, Morena A, Rocco A, et al: BAG3 protein delocalisation in prostate carcinoma. Tumour Biol. 31:461–469. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Liu P, Xu B, Li J and Lu H: BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis. FEBS Lett. 583:401–406. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Uddin S, Hussain AR, Siraj AK, Manogaran PS, Al-Jomah NA, Moorji A, Atizado V, Al-Dayel F, Belgaumi A, El-Solh H, et al: Role of phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival. Blood. 108:4178–4186. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Fang X, Jiang Y, Feng L, Chen H, Zhen C, Ding M and Wang X: Blockade of PI3K/AKT pathway enhances sensitivity of Raji cells to chemotherapy through down-regulation of HSP70. Cancer Cell Int. 13:482013. View Article : Google Scholar : PubMed/NCBI

24 

West KA, Castillo SS and Dennis PA: Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updat. 5:234–248. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Hasselblom S, Hansson U, Olsson M, Torén L, Bergström A, Nilsson-Ehle H and Andersson PO: High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Br J Haematol. 149:560–568. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Du ZX, Zhang HY, Meng X, Gao YY, Zou RL, Liu BQ, Guan Y and Wang HQ: Proteasome inhibitor MG132 induces BAG3 expression through activation of heat shock factor 1. J Cell Physiol. 218:631–637. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Rapino F, Abhari BA, Jung M and Fulda S: NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways. Cell Death Dis. 6:e16922015. View Article : Google Scholar : PubMed/NCBI

28 

Wang HQ, Liu BQ, Gao YY, Meng X, Guan Y, Zhang HY and Du ZX: Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression. Br J Pharmacol. 158:1405–1412. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Huang J, Ding T, Yang M, Liu H, Sun X and Jin J: Antitumor activity and drug interactions of proteasome inhibitor Bortezomib in human high-risk myelodysplastic syndrome cells. Int J Hematol. 93:482–493. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP, Chen PJ and Cheng AL: Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 284:11121–11133. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Yeramian A, Sorolla A, Velasco A, Santacana M, Dolcet X, Valls J, Abal L, Moreno S, Egido R, Casanova JM, et al: Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway. Int J Cancer. 130:967–978. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Ruggeri B, Miknyoczki S, Dorsey B and Hui AM: The development and pharmacology of proteasome inhibitors for the management and treatment of cancer. Adv Pharmacol. 57:91–135. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Crawford LJ, Walker B and Irvine AE: Proteasome inhibitors: A therapeutic strategy for haematological malignancy. Front Biosci. 13:4285–4296. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Park DJ and Lenz HJ: The role of proteasome inhibitors in solid tumors. Ann Med. 36:296–303. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Jones MD, Liu JC, Barthel TK, Hussain S, Lovria E, Cheng D, Schoonmaker JA, Mulay S, Ayers DC, Bouxsein ML, et al: A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes. Clin Cancer Res. 16:4978–4989. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Manasanch EE and Orlowski RZ: Proteasome inhibitors in cancer therapy. Nat Rev Clin Oncol. 14:417–433. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Voorhees PM and Orlowski RZ: The proteasome and proteasome inhibitors in cancer therapy. Annu Rev Pharmacol Toxicol. 46:189–213. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Bu R, Hussain AR, Al-Obaisi KA, Ahmed M, Uddin S and Al-Kuraya KS: Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma. Leuk Lymphoma. 55:415–424. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Dunleavy K, Pittaluga S, Czuczman MS, Dave SS, Wright G, Grant N, Shovlin M, Jaffe ES, Janik JE, Staudt LM, et al: Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma. Blood. 113:6069–6076. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Wright JJ: Combination therapy of bortezomib with novel targeted agents: an emerging treatment strategy. Clin Cancer Res. 16:4094–4104. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Dasmahapatra G, Patel H, Dent P, Fisher RI, Friedberg J and Grant S: The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib. Br J Haematol. 161:43–56. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Fenske TS, Shah NM, Kim KM, Saha S, Zhang C, Baim AE, Farnen JP, Onitilo AA, Blank JH, Ahuja H, et al: A phase 2 study of weekly temsirolimus and bortezomib for relapsed or refractory B-cell non-Hodgkin lymphoma: A wisconsin oncology network study. Cancer. 121:3465–3471. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Yu W, Chen Y, Xiang R, Xu W, Wang Y, Tong J, Zhang N, Wu Y and Yan H: Novel phosphatidylinositol 3-kinase inhibitor BKM120 enhances the sensitivity of multiple myeloma to bortezomib and overcomes resistance. Leuk Lymphoma. 58:428–437. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Qu FL, Xia B, Li SX, Tian C, Yang HL, Li Q, Wang YF, Yu Y and Zhang YZ: Synergistic suppression of the PI3K inhibitor CAL-101 with bortezomib on mantle cell lymphoma growth. Cancer Biol Med. 12:401–408. 2015.PubMed/NCBI

45 

Lin L, Gaut D, Hu K, Yan H, Yin D and Koeffler HP: Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3-kinase inhibitor (ZSTK474). Int J Oncol. 44:557–562. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Kim A, Park S, Lee JE, Jang WS, Lee SJ, Kang HJ and Lee SS: The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells. Leuk Res. 36:912–920. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Franceschelli S, Rosati A, Lerose R, De Nicola S, Turco MC and Pascale M: Bag3 gene expression is regulated by heat shock factor 1. J Cell Physiol. 215:575–577. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yuan T, Zhang F, Zhou X, Li Y, Zhang Y, Xu Y and Wang X: Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3. Oncol Lett 17: 3719-3726, 2019.
APA
Yuan, T., Zhang, F., Zhou, X., Li, Y., Zhang, Y., Xu, Y., & Wang, X. (2019). Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3. Oncology Letters, 17, 3719-3726. https://doi.org/10.3892/ol.2019.10029
MLA
Yuan, T., Zhang, F., Zhou, X., Li, Y., Zhang, Y., Xu, Y., Wang, X."Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3". Oncology Letters 17.4 (2019): 3719-3726.
Chicago
Yuan, T., Zhang, F., Zhou, X., Li, Y., Zhang, Y., Xu, Y., Wang, X."Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3". Oncology Letters 17, no. 4 (2019): 3719-3726. https://doi.org/10.3892/ol.2019.10029
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan T, Zhang F, Zhou X, Li Y, Zhang Y, Xu Y and Wang X: Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3. Oncol Lett 17: 3719-3726, 2019.
APA
Yuan, T., Zhang, F., Zhou, X., Li, Y., Zhang, Y., Xu, Y., & Wang, X. (2019). Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3. Oncology Letters, 17, 3719-3726. https://doi.org/10.3892/ol.2019.10029
MLA
Yuan, T., Zhang, F., Zhou, X., Li, Y., Zhang, Y., Xu, Y., Wang, X."Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3". Oncology Letters 17.4 (2019): 3719-3726.
Chicago
Yuan, T., Zhang, F., Zhou, X., Li, Y., Zhang, Y., Xu, Y., Wang, X."Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3". Oncology Letters 17, no. 4 (2019): 3719-3726. https://doi.org/10.3892/ol.2019.10029
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